UniProt: A8WGE8

Database: UniProt
Entry: A8WGE8_XENTR

LinkDB:  A8WGE8_XENTR 
Original site:  A8WGE8_XENTR

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Ontology (4)   
   GO (4)   
Gene (6)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
   XENBASE (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (22)   
   InterPro (11)   
   Pfam (6)   
   PROSITE (2)   
   SMART (3)   
Literature (2)   
   PubMed (2)   
All databases (37)   

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ID   A8WGE8_XENTR            Unreviewed;      1503 AA.
AC   A8WGE8; A0A6I8SFR9;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
GN   Name=ncoa1 {ECO:0000313|EMBL:AAI54684.1,
GN   ECO:0000313|Ensembl:ENSXETP00000091299,
GN   ECO:0000313|RefSeq:NP_001106383.1, ECO:0000313|RefSeq:XP_031757328.1,
GN   ECO:0000313|Xenbase:XB-GENE-494349};
GN   Synonyms=bhlhe42 {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, bhlhe74
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, f-src-1
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, kat13a
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, ncoa-1
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, rip160
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, src-1
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, src1
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1}, Xsrc1
GN   {ECO:0000313|RefSeq:NP_001106383.1,
GN   ECO:0000313|RefSeq:XP_031757328.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI54684.1};
RN   [1] {ECO:0000313|RefSeq:NP_001106383.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAI54684.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI54684.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSXETP00000091299}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000091299};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [4] {ECO:0000313|Ensembl:ENSXETP00000091299}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [5] {ECO:0000313|RefSeq:NP_001106383.1, ECO:0000313|RefSeq:XP_031757328.1}
RP   IDENTIFICATION.
RC   STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031757328.1};
RC   TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031757328.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
CC   -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC       family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR   EMBL; BC154683; AAI54684.1; -; mRNA.
DR   RefSeq; NP_001106383.1; NM_001112912.1.
DR   RefSeq; XP_031757328.1; XM_031901468.1.
DR   DNASU; 100127189; -.
DR   Ensembl; ENSXETT00000096656; ENSXETP00000091299; ENSXETG00000021173.
DR   GeneID; 100127189; -.
DR   KEGG; xtr:100127189; -.
DR   AGR; Xenbase:XB-GENE-494349; -.
DR   CTD; 8648; -.
DR   Xenbase; XB-GENE-494349; ncoa1.
DR   Reactome; R-XTR-159418; Recycling of bile acids and salts.
DR   Reactome; R-XTR-192105; Synthesis of bile acids and bile salts.
DR   Reactome; R-XTR-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR   Reactome; R-XTR-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
DR   Reactome; R-XTR-211976; Endogenous sterols.
DR   Reactome; R-XTR-3214847; HATs acetylate histones.
DR   Reactome; R-XTR-3899300; SUMOylation of transcription cofactors.
DR   Reactome; R-XTR-9018519; Estrogen-dependent gene expression.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Bgee; ENSXETG00000021173; Expressed in neurula embryo and 9 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 6.10.140.410; -; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR010011; NCO_DUF1518.
DR   InterPro; IPR009110; Nuc_rcpt_coact.
DR   InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR   InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR   InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR014935; SRC/p160_LXXLL.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR   PANTHER; PTHR10684:SF1; NUCLEAR RECEPTOR COACTIVATOR 1; 1.
DR   Pfam; PF07469; DUF1518; 2.
DR   Pfam; PF16665; NCOA_u2; 2.
DR   Pfam; PF08815; Nuc_rec_co-act; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF14598; PAS_11; 1.
DR   Pfam; PF08832; SRC-1; 1.
DR   PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 4.
DR   SMART; SM01151; DUF1518; 2.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   2: Evidence at transcript level;
KW   Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW   Receptor {ECO:0000313|RefSeq:NP_001106383.1,
KW   ECO:0000313|RefSeq:XP_031757328.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR038181};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR038181}.
FT   DOMAIN          21..78
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          108..179
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          600..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          706..753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          894..914
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1211..1262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1300..1370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1473..1503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..477
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        707..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        739..753
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        897..911
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1231..1245
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1503 AA;  162769 MW;  CE35D0EF9822D9EC CRC64;
     MSGLGDSSAD PASQDRKRKA LPCDTAQSTE KRRREQENKY LEELAELLSA NIGDIDSLSV
     KPDKCKILIK RMDQIQQLKK KKQEKALGAD DDVQKSDISS SSGGVIEKES LGPLLLEALD
     GFFFVVNQEG RIVFVSENVT NYLGYKQEEL MKDSIYSILH VGDHEEFVKN LLPKSLVNGV
     PWSQEASRRN SHTLNCRMLI RPPDDAGVEN QEARQRYEVM QCFTVSQPKS FKEEGEDFQS
     CLICIARRLP RPAPITSLES FITKQDATGK IISIDTSSLR ASGSLGWEDL VRKCIYAFFQ
     AQGTEPSYAK QLFQEVMTRG TACSPSYKFT LSDGTELSAH TKCKLCYPQS PDVQPYIMGI
     HIIERDQSSL CTQENTNSGM SLPRLSPSVN LTITPTQGMP FSSTTSPSSG GMLSSGINQH
     QVAGLHNSNS SNTSQANFGC SPGSQIGTNV ALSLGQAGPQ NSNNLNLNNS PMSSPGISPP
     QFMSPRPRAS PGLVSRSRAS GNPFSPPMPA MHSPVGISNS ICNNNNNRPF SNVPLNSMPV
     VNDPNTPLGF STPSPGMTNN VSTTNNGRLF SNTPMNTVQG INEGPNPTVG YSTTSPVLRQ
     LNSQNSPGRL NMQPIKMEPK DNSGNSDRTV EGETKPSLAT SSNKLVQLLA TTAEQQLRDV
     DTNCRDPLTC HVVTNTSCGS SSSGTCPSSH SSLTERHKIL HRLLQEGSPS DISSLSIDHE
     KKNTGSANNQ TPGGPPEVKM ESESDKKKDS KDHQLLRYLL DKDEKEVKSS SALTLEDVKV
     KVEKEQVDQC SSTPTTLIKA GQEDIKLETQ NQFADDFDQL DQLLPTLDKA AQLPGMVPDR
     TDNSVPLKTE MLPSSLQTGT VARTPTRLNN FNGMNTNQSP FGFCDPMDPV QLDLNPFPAP
     SDTSPRSGLT PDQGRGVTHD ATAFQSDPGL PDPDLGITEP QFGQPGIGDQ IPWNDGLAPM
     NRVTQSAQEE IDDFLCPPTT AEGRNDEKAL LEQLVSFLSG KDENELAELD RALGIDKLVQ
     GGGLDVVNDR FPQQSIAPVI MEQKPGLYPQ QYPSASPNPG LPFFNMVRQK AAFGSVPVQV
     QPPQARGTYP NTMGMQPRQA LARSVTTSNQ LRLQLQQRLQ GQQQVLHQNR QANLNQFGVV
     NTVAMGMRPG MQQAISTQQP PLNAQMLAQR QRELYSQQHR QRQLMQQRSI LMRQQGFGNN
     LAPAGSLPVT MGAGRLPQGP PQQFPYPHSY GTNPGNPPPS TSPFSPLATT PEATLANRGG
     GNGNGIVNRG MMGNVGGQFG SGINPQMQQN VFQYSATGIS QQGDPTFAPS LSPTSPLMSP
     RITPSQSPML QQTPSTPGYQ SPDLKTWQQS PLGNSGVFSQ GGQTQPPPGQ QGMYNNMSIT
     VSMGGGNTGV QNVNQMTGQM QMSSLPMSNM NAMCTEQQVS DPALRPSGLY CNQLSSTDLL
     KTEPETGQVQ QVQVFADVQC TVNLVGGDPY INQPGSITSQ KATTGPQTPQ AQQKSLLQQL
     LTE
//

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