ID A8WGG2_XENTR Unreviewed; 1440 AA.
AC A8WGG2;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Alpha-2-macroglobulin-like 1 {ECO:0000313|RefSeq:NP_001106498.1};
DE SubName: Full=LOC100127688 protein {ECO:0000313|EMBL:AAI54699.1};
GN Name=a2ml1 {ECO:0000313|RefSeq:NP_001106498.1,
GN ECO:0000313|Xenbase:XB-GENE-5943821};
GN Synonyms=LOC100127688 {ECO:0000313|EMBL:AAI54699.1}, Panza
GN {ECO:0000313|RefSeq:NP_001106498.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI54699.1};
RN [1] {ECO:0000313|RefSeq:NP_001106498.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI54699.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI54699.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001106498.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR EMBL; BC154698; AAI54699.1; -; mRNA.
DR RefSeq; NP_001106498.1; NM_001113027.1.
DR GeneID; 100127688; -.
DR KEGG; xtr:100127688; -.
DR AGR; Xenbase:XB-GENE-5943821; -.
DR CTD; 144568; -.
DR Xenbase; XB-GENE-5943821; a2ml1.
DR OrthoDB; 2970602at2759; -.
DR Proteomes; UP000008143; Chromosome 7.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 2.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF177; PROLACTIN-INDUCED PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 420..574
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 714..803
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1339..1426
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1440 AA; 159708 MW; 13AB515BC7278476 CRC64;
MRCHSSEQAC VHLSGAEGDS RIQVTLNMAE RNSTVIERNL QQKSLFSCVT FQVPPPSEGN
EEVATMEILI ESAGETITNS SKVLVKRRRT STFIQTDKAV YKPGQTVRFR VVSLKENLQP
GESQISVIQL QDPNKNRIAQ WLDVTLTQGI AELSLPLSPE PSLGEYSIHV GDTVHYFSVE
EYVLPKFEVS FQFPKVVFFT SEQFQLKTCG RYTYGKPVQG TYKATVCRKV IRYWWGHNDD
RSDLCVNFSG KLDQSGCSTL TATSENFNLT YNTHEMGLEG RSTITEGGTG VEYSGSGKTI
ISSLVTSCSF LDADSNYKPG IPYSGTVKVV DANDDPIPNQ IVYLTSHSNE VNKTLVSDEN
GLASFQLENT AEWKGQLSLR ASTTTQDAGF DFLQGRLITP NDVSASLMLK PFHSPSKSFL
KLHSQQGALP CEGQRDVRVE YIIPNSALGM EVKHMELHYL VASKGSVKDS GSVEVPITSE
GGGSSELRGE VSIKLTLSAD VSPTLRALAF ISLPNGELVA DSATFKLQRC FKNKVSVGFS
PDEVLPGADV SLQVQAAAGS LCGLRVVDQS VVLMKPDKEL TDDQIHNLFP FPDFGGYDAR
VQDSDDHCPF YSWFHRPMWK RSIVLPPWHM PHEDEVDVYS LFKDMRLKIV TSAEIKKPLR
CREPEFALQY NVLAHPRIAD AGDGLVRAMP KAVGVGNELT EPAAEIIRAY FPETWIWQLE
PVGESGRAEV HGSAPDTITE WNAGAFCMGP SGFGISPPTS LRAFQPFFVE LTLPYSVVRG
ESFTLKASVF NYLKQCIKVQ TTLQPSLELE QEPCADCQYS SCICADESKT FYWNLKASNL
GEVNITVRTE ALNTQDMCNN EIPIVPKQGH SDTVIKPLLV QPGGVLIEKS HSSLICSPEG
EDHSKTEDIS LNVPENILEG SERAYVTALG DLMGTAMQNL DRLLAMPYGC GEQNMVLFAP
NIFILQYLEN THQLSPEIQS KAKGFLESGY QRQLTYKRND GSYSAFGSRD PEGNTWLTAF
VVKSFSKARP YIFIDGDHLN HSFSWLKDKR QRSGCFRSVG KLFNNAMKGG VDDEISLSAY
VTIALMEAGL SKEDPMVSDA LSCLRKAARK VSSAYTQALL AYTFTLSDDT KHREKLLAKL
EEKAVRKDGQ LHWERKPASE ASDLPYWYRA PSAEVELTSY VLLALLSGPN KDLGKASEIV
NWLSKQQNPY GGFSSTQDTV VALQALAKYA EATFSDKGDV TVTVTSKTGF HQQFHVDQTN
RLLLQKASLP DIPGEYSLSA TGSSCVYVQT VLRYNIPPPR SDATFSVRVE TQPKQCPQEP
MKQMHIDIYI QYTGSREKSN MALVEVKMLS GFIPVKSTIK QLVSSNTIKR SEIQTDMVTL
YLNELGHDPV HFSIMVEQDI EVKNLKPATV KVYDYYETAE HAVTEYNSPC SSDKEAENTR
//
