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Database: UniProt
Entry: A8WM46_CAEBR
LinkDB: A8WM46_CAEBR
Original site: A8WM46_CAEBR 
ID   A8WM46_CAEBR            Unreviewed;      3928 AA.
AC   A8WM46;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   24-JAN-2024, entry version 111.
DE   SubName: Full=Protein CBR-FBN-1 {ECO:0000313|EMBL:CAP21550.2};
GN   Name=fbn-1 {ECO:0000313|WormBase:CBG00005a};
GN   Synonyms=Cbr-fbn-1 {ECO:0000313|EMBL:CAP21550.2};
GN   ORFNames=CBG00005 {ECO:0000313|WormBase:CBG00005a}, CBG_00005
GN   {ECO:0000313|EMBL:CAP21550.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP21550.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP21550.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP21550.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; HE601477; CAP21550.2; -; Genomic_DNA.
DR   STRING; 6238.A8WM46; -.
DR   WormBase; CBG00005a; CBP39399; WBGene00023525; Cbr-fbn-1.
DR   eggNOG; KOG1217; Eukaryota.
DR   InParanoid; A8WM46; -.
DR   OrthoDB; 2881355at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 13.
DR   Gene3D; 2.10.25.10; Laminin; 17.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001507; ZP_dom.
DR   PANTHER; PTHR24039:SF28; FBN-1A.1; 1.
DR   PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR   Pfam; PF12947; EGF_3; 4.
DR   Pfam; PF07645; EGF_CA; 8.
DR   SMART; SM00181; EGF; 29.
DR   SMART; SM00179; EGF_CA; 16.
DR   SMART; SM00241; ZP; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 5.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR   PROSITE; PS00010; ASX_HYDROXYL; 9.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 16.
DR   PROSITE; PS50026; EGF_3; 15.
DR   PROSITE; PS01187; EGF_CA; 7.
DR   PROSITE; PS51034; ZP_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..3928
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002729232"
FT   TRANSMEM        3892..3912
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          119..153
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          156..194
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          195..234
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          286..327
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          372..409
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1612..1653
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1654..1695
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1746..1783
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1786..1826
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1879..1920
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1921..1961
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2018..2058
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2059..2100
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          3411..3449
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          3540..3580
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          3591..3832
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|PROSITE:PS51034"
FT   REGION          716..1559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2110..2461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2555..3243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..772
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        810..1010
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1078..1104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1120..1134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1205..1228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1237..1251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1272..1304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1323..1358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1384..1434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1471..1535
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2114..2254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2284..2454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2581..3192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3202..3243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        122..132
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        143..152
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        399..408
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   3928 AA;  407781 MW;  91D315742745A9B3 CRC64;
     MSTRSRGSCP TSWLMTPLVL LVLCRGERLE IWEFLGAVTK SLKISSTHRH QISDRRSSSI
     LTPQQLFVSI AQQLAQWKRP LLASDPTDLH IHNMSSLCDG KQDCFVNPAM HDEVFPYCEH
     KCESTCSGKG ACLYDGSKPQ CYCDSGFSGA ACELQDKNEC LEHPCHMMAQ CQNTLGSYEC
     RCLPGYQGNG HECSDIDECA DNIATRCPEH SQCINLPGTY YCNCTQGFSP KGNQGSGLDK
     CADINECETG AHNCETNEIC ENTIGSFKCV TKCSPGYSLI DGKCEDVNEC DSEKLHKCDV
     RAECINTVGG YECECEEGFD GDGKNCQLFR FSAKSSCRKN SAICDRHASC NIFLDICDCK
     TGYTGDGITC HDVNECDAKE TPCSEGGRCL NLDGGYVCCK DGQDDAACIK VINLTTIFPY
     QRAFCSGGCC DNAICSNATC ACIDGFRGDP HKKCVDINEC VENDSVCGGV GDRCVNLFGG
     YKCCQHGSQE VECTDQAFSS DSSTVSSHGA DFTTTGEQVI EGSGSIQTSS GGSITVTRGL
     IPKEVELTTS GRLACTSYCP PNSECVGGFC ECVKGYGGNA LVGCEDVDEC ITETCNVEAN
     EWCVNLIGGF VCCNPTNATH DDCIGLEITK EKGLHVIGPN EEDTVVATRS NHSVTSDQLI
     TEVVQQSKNF SSGQIILTRK SVTGGEAVTQ TTDGDGEFGL EISAKDFGIT LPATLEPRVE
     GSGKSPVAGV WTEEEDGGED DDLMEASGSH GSWSTTINGT GFTGSPRSEG TIRVRITTLG
     EDGETETATK PGITVPGKDG KLAIEKEGHE SVSSGSSATS SSGSTGSGAS GSTATGKSGS
     SATSSSGSSS SGSTESGSSG SSATSSSGST SSGESGSTAT EESGKSEPSG ATGTESSGKS
     ESGASGESGP AGSSTTSSSG STESGASGSN ATSSSGSSAT GESGSSSSGS TESGASGSNA
     TGGSGATGNE SSESAGTTAS PESVTASRES VEGSGTTPSE STSSLPEGSG EWIETGSKGH
     FERGNKVSVS HGNGKPEGSG PKESGKPEVP GSQGSGAKES GAGKPGSGSR GPEITTDGEE
     SESTSSGSGK PKNPKITTDG EGSKSTPIGD GKHPEDVEGS GILTTSSGGK NSTLEHGTKL
     VEVKPEGSDK NPGVGLEISA GKVTSAPEDK EKSNEVGLEI VWESTTPEPT TPDTDNVGLE
     ISGRDLITKR PHQIEGSGTG DEEISEFPKF EFGGNSKIQN HKISAATTRD VSKSTKKPRL
     EIDGGDNGET SGVDGKASTP SPTSPGAPES TTPSAPTTAP EDVTPETGSG EPGIPDGSGE
     SSTAAPEGVS PTSSAPAPEV PTTPEGSEES TKTPEGVEGS GEATTEAAKP SEATKAPKAT
     SAAPESFSKP SEATKAPEAT SSAPEASAKP SEATKAPEAT STTPGSSTKP SEAPKATSAA
     PEASTKLSEA TKASEKPSEA TKAPEATSAA PESFTKKSEV TKAPEATTAT SPEEETTTQE
     PLILTAAPSK APESSTKPSE APEASSESTA APPTAQPATV IPPQNREEKP EPTKETFALP
     TTTEKPVNET IENTKCMSSD ECGLDALCER RTGVCRCEPG FEGAPPKKAC VDVDECATGD
     HKCHDSARCQ NFIGGYACFC PTGFRKTDDG SCEDIDECKE HNSTCCGANA HCVNKPGTYS
     CECENGFLGD GYHCVPSTKK PCDKEQSTKS HCAESNMSCE VDTTDGSVEC KECMSGYKKS
     GTTCEDINEC DEQSPCSPSA SCVNLNGTFS CSCKPGFRGD GFMCTDINEC DEKHPCHPHA
     ECTNLEGSFK CECHSGFEGD GIKKCTNPLE RSCEDVEKFC GRVDHVSCLS VRIYNGSLSS
     VCECEPGFRF EKESNSCVDI DECEENRNNC DPASAVCVNT EGSFKCECAE GYEGEGGVCT
     DIDECDRGMA GCDSMAMCIN RMGSCGCKCM AGYTGDGAHC TKIEEPKEAS KTACTEEWSR
     LCELEKKQCA VDEEEVPQCG ACLPGHHPIN GTCQSLQISG LCAQKNDCNK HAECIDILPD
     SHFCSCPDGF IGDGMMCDDV DECNNAGMCD DENSKCENTI GSFNCVCLEG FKKSDDDKCV
     LKTPNREKIE INEENSSSTP SESQKPESTT QGTVTTSVLS SEPTSEAPTS STSPVTSSEK
     ASESTTSSES PVTPSETSVT TSKSPTSSER ASESTTSSAL PVTSSESNRK STKAPESITS
     SETSTVSSTS SQTSETTSEA PTSSEAPVTS SESHRESTKT SESTTSSKAL VTSLPEYTKK
     PEDITSSESP SVTSSKAPEV VTSSLATPES STSPKSAITS SEGTATSSES STVSSTSSES
     TTVSPKTPEV STTFTKSPVT SPKTSEATKP SETPSTVPGT SSESTTVSSE SPTSSESPVT
     SSAAPEPTTS SEKSPVKSTS APKDVKSSEA PVTSTSASPE DITSSTTSTK PSEMSVXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXEKPLEEPT
     STEDSLTVSV RIHELSTTSS ESTESTTTSS ESSKPTVTSS VSPVTSSNVS EAVTSSESPT
     TVYVTSSVSP ATSSESPESS TPFNQGRTPL TSTTTSSEVT TSKIESSESS TASPEEETTT
     QEPLILTATP SKAPESTTAS EATTQPSKIS SESPVTSSEA VTPSEKPVTS SVPSTSSESP
     VTLSQSRQSS ETPTTSSTEA PDVDVSDKPV TTSSESPGTS PESVTSTVKS TKSPVTSSES
     PVTTSSVKST SPVTSTPEST SSESPITSPE ATTSSGTVTS TSSVSVTSSE ATTPSEGSTS
     SVTSSEPPVT SPEATTSSVA PVTTASVKST SSESPSTVSS KSPEDVTSPS TLSVTSSEPP
     STVTFSESPV TSSEKSTSPS TSSEAATSSG SPVTTSSVKF TPPEDATSPS TSSVTSSEAP
     TSSESPSNVS SKSLETTTSS GKSTSPSTSS FTSSKATTSP EPTTSSESPV FMSSVKSTSP
     SASSVKSTTP EDVTSPSVTS SESPTPSESP TSPESPNTVS SNSPEDGTSP STSSEATRPL
     VQSRTTVTSS VTSSEPTASS ESPTSTPRVR LVTGTPDDVK NENSGNSEST TTTSPAPPTP
     ITTEAPITSG NRGPPSIQPP PELFTTTSSE SPAPSNGGYG EEIQEETSSS SSTTTTSTTE
     ARELKGATTE LYIFPASLCS TVTCHSLATC EPSTGVCICR DGFIGDGTSS CSKKSTADCI
     SLPSLCAENA KCDNSARSCE CDAGYIGDGY VCSPHPQDCV LRDNLCSPEA ICQNRRCQCL
     PGFTGDGVKC VSIHERASNC SQCDANAHCV GGTTCKCNPG YFGNGLCCVP DPLDCVHFTG
     ICHPNAVCNP DTRQCQCSSG FSGNGVSCFP QKSCRTDKSV CAKNAICLPT GSCICRHGFK
     GDPFYKCTSL VAKEPSNAQD LSDVSSCVTP CDASSQLCIS GECICKPGFR QNPGSKTCAD
     IDECAEKTHR CNRIATCRNT FGSHVCSCPE GHVGDGVTCV PHVNQGKLSV YCEADGMTLV
     LGNETSDFEG KIFVKGQAEN PYCSKSFSAL LNSHKPYVFK VAFQHCDVQL LDNHTMASTV
     VVQKHAMFLT NKADSYDLRC QYPIGSRAVQ SHVNVSELAT TSTLTDKNST LAPICRLSVS
     NDQHSSISSA MVGDTLKLAL EVTPSENFGI LPRNCFAVNI ESGERYTLTD EQGCAIDESL
     FPQWSVTNSA KVQAMFRTFK WPDSSMIRFQ CDCNPCVGQC TVPSCISSSR FRRHHQTTSP
     LLNDEIRQEL VLMSGVESLA VSSIINVKDS MSDEDDVVAS ESLTTSSICV KWAPLLIALG
     SFVVCSLVLL YLCSKKPKTM DLESEVRF
//
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