ID A8WM46_CAEBR Unreviewed; 3928 AA.
AC A8WM46;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 24-JAN-2024, entry version 111.
DE SubName: Full=Protein CBR-FBN-1 {ECO:0000313|EMBL:CAP21550.2};
GN Name=fbn-1 {ECO:0000313|WormBase:CBG00005a};
GN Synonyms=Cbr-fbn-1 {ECO:0000313|EMBL:CAP21550.2};
GN ORFNames=CBG00005 {ECO:0000313|WormBase:CBG00005a}, CBG_00005
GN {ECO:0000313|EMBL:CAP21550.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP21550.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP21550.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP21550.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; HE601477; CAP21550.2; -; Genomic_DNA.
DR STRING; 6238.A8WM46; -.
DR WormBase; CBG00005a; CBP39399; WBGene00023525; Cbr-fbn-1.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A8WM46; -.
DR OrthoDB; 2881355at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR24039:SF28; FBN-1A.1; 1.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR Pfam; PF12947; EGF_3; 4.
DR Pfam; PF07645; EGF_CA; 8.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 16.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 16.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..3928
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002729232"
FT TRANSMEM 3892..3912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..153
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 156..194
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 195..234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 286..327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 372..409
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1612..1653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1654..1695
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1746..1783
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1786..1826
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1879..1920
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1921..1961
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2018..2058
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2059..2100
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3411..3449
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3540..3580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3591..3832
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 716..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2110..2461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2555..3243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2114..2254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2284..2454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2581..3192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3202..3243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 122..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 143..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 399..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3928 AA; 407781 MW; 91D315742745A9B3 CRC64;
MSTRSRGSCP TSWLMTPLVL LVLCRGERLE IWEFLGAVTK SLKISSTHRH QISDRRSSSI
LTPQQLFVSI AQQLAQWKRP LLASDPTDLH IHNMSSLCDG KQDCFVNPAM HDEVFPYCEH
KCESTCSGKG ACLYDGSKPQ CYCDSGFSGA ACELQDKNEC LEHPCHMMAQ CQNTLGSYEC
RCLPGYQGNG HECSDIDECA DNIATRCPEH SQCINLPGTY YCNCTQGFSP KGNQGSGLDK
CADINECETG AHNCETNEIC ENTIGSFKCV TKCSPGYSLI DGKCEDVNEC DSEKLHKCDV
RAECINTVGG YECECEEGFD GDGKNCQLFR FSAKSSCRKN SAICDRHASC NIFLDICDCK
TGYTGDGITC HDVNECDAKE TPCSEGGRCL NLDGGYVCCK DGQDDAACIK VINLTTIFPY
QRAFCSGGCC DNAICSNATC ACIDGFRGDP HKKCVDINEC VENDSVCGGV GDRCVNLFGG
YKCCQHGSQE VECTDQAFSS DSSTVSSHGA DFTTTGEQVI EGSGSIQTSS GGSITVTRGL
IPKEVELTTS GRLACTSYCP PNSECVGGFC ECVKGYGGNA LVGCEDVDEC ITETCNVEAN
EWCVNLIGGF VCCNPTNATH DDCIGLEITK EKGLHVIGPN EEDTVVATRS NHSVTSDQLI
TEVVQQSKNF SSGQIILTRK SVTGGEAVTQ TTDGDGEFGL EISAKDFGIT LPATLEPRVE
GSGKSPVAGV WTEEEDGGED DDLMEASGSH GSWSTTINGT GFTGSPRSEG TIRVRITTLG
EDGETETATK PGITVPGKDG KLAIEKEGHE SVSSGSSATS SSGSTGSGAS GSTATGKSGS
SATSSSGSSS SGSTESGSSG SSATSSSGST SSGESGSTAT EESGKSEPSG ATGTESSGKS
ESGASGESGP AGSSTTSSSG STESGASGSN ATSSSGSSAT GESGSSSSGS TESGASGSNA
TGGSGATGNE SSESAGTTAS PESVTASRES VEGSGTTPSE STSSLPEGSG EWIETGSKGH
FERGNKVSVS HGNGKPEGSG PKESGKPEVP GSQGSGAKES GAGKPGSGSR GPEITTDGEE
SESTSSGSGK PKNPKITTDG EGSKSTPIGD GKHPEDVEGS GILTTSSGGK NSTLEHGTKL
VEVKPEGSDK NPGVGLEISA GKVTSAPEDK EKSNEVGLEI VWESTTPEPT TPDTDNVGLE
ISGRDLITKR PHQIEGSGTG DEEISEFPKF EFGGNSKIQN HKISAATTRD VSKSTKKPRL
EIDGGDNGET SGVDGKASTP SPTSPGAPES TTPSAPTTAP EDVTPETGSG EPGIPDGSGE
SSTAAPEGVS PTSSAPAPEV PTTPEGSEES TKTPEGVEGS GEATTEAAKP SEATKAPKAT
SAAPESFSKP SEATKAPEAT SSAPEASAKP SEATKAPEAT STTPGSSTKP SEAPKATSAA
PEASTKLSEA TKASEKPSEA TKAPEATSAA PESFTKKSEV TKAPEATTAT SPEEETTTQE
PLILTAAPSK APESSTKPSE APEASSESTA APPTAQPATV IPPQNREEKP EPTKETFALP
TTTEKPVNET IENTKCMSSD ECGLDALCER RTGVCRCEPG FEGAPPKKAC VDVDECATGD
HKCHDSARCQ NFIGGYACFC PTGFRKTDDG SCEDIDECKE HNSTCCGANA HCVNKPGTYS
CECENGFLGD GYHCVPSTKK PCDKEQSTKS HCAESNMSCE VDTTDGSVEC KECMSGYKKS
GTTCEDINEC DEQSPCSPSA SCVNLNGTFS CSCKPGFRGD GFMCTDINEC DEKHPCHPHA
ECTNLEGSFK CECHSGFEGD GIKKCTNPLE RSCEDVEKFC GRVDHVSCLS VRIYNGSLSS
VCECEPGFRF EKESNSCVDI DECEENRNNC DPASAVCVNT EGSFKCECAE GYEGEGGVCT
DIDECDRGMA GCDSMAMCIN RMGSCGCKCM AGYTGDGAHC TKIEEPKEAS KTACTEEWSR
LCELEKKQCA VDEEEVPQCG ACLPGHHPIN GTCQSLQISG LCAQKNDCNK HAECIDILPD
SHFCSCPDGF IGDGMMCDDV DECNNAGMCD DENSKCENTI GSFNCVCLEG FKKSDDDKCV
LKTPNREKIE INEENSSSTP SESQKPESTT QGTVTTSVLS SEPTSEAPTS STSPVTSSEK
ASESTTSSES PVTPSETSVT TSKSPTSSER ASESTTSSAL PVTSSESNRK STKAPESITS
SETSTVSSTS SQTSETTSEA PTSSEAPVTS SESHRESTKT SESTTSSKAL VTSLPEYTKK
PEDITSSESP SVTSSKAPEV VTSSLATPES STSPKSAITS SEGTATSSES STVSSTSSES
TTVSPKTPEV STTFTKSPVT SPKTSEATKP SETPSTVPGT SSESTTVSSE SPTSSESPVT
SSAAPEPTTS SEKSPVKSTS APKDVKSSEA PVTSTSASPE DITSSTTSTK PSEMSVXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXEKPLEEPT
STEDSLTVSV RIHELSTTSS ESTESTTTSS ESSKPTVTSS VSPVTSSNVS EAVTSSESPT
TVYVTSSVSP ATSSESPESS TPFNQGRTPL TSTTTSSEVT TSKIESSESS TASPEEETTT
QEPLILTATP SKAPESTTAS EATTQPSKIS SESPVTSSEA VTPSEKPVTS SVPSTSSESP
VTLSQSRQSS ETPTTSSTEA PDVDVSDKPV TTSSESPGTS PESVTSTVKS TKSPVTSSES
PVTTSSVKST SPVTSTPEST SSESPITSPE ATTSSGTVTS TSSVSVTSSE ATTPSEGSTS
SVTSSEPPVT SPEATTSSVA PVTTASVKST SSESPSTVSS KSPEDVTSPS TLSVTSSEPP
STVTFSESPV TSSEKSTSPS TSSEAATSSG SPVTTSSVKF TPPEDATSPS TSSVTSSEAP
TSSESPSNVS SKSLETTTSS GKSTSPSTSS FTSSKATTSP EPTTSSESPV FMSSVKSTSP
SASSVKSTTP EDVTSPSVTS SESPTPSESP TSPESPNTVS SNSPEDGTSP STSSEATRPL
VQSRTTVTSS VTSSEPTASS ESPTSTPRVR LVTGTPDDVK NENSGNSEST TTTSPAPPTP
ITTEAPITSG NRGPPSIQPP PELFTTTSSE SPAPSNGGYG EEIQEETSSS SSTTTTSTTE
ARELKGATTE LYIFPASLCS TVTCHSLATC EPSTGVCICR DGFIGDGTSS CSKKSTADCI
SLPSLCAENA KCDNSARSCE CDAGYIGDGY VCSPHPQDCV LRDNLCSPEA ICQNRRCQCL
PGFTGDGVKC VSIHERASNC SQCDANAHCV GGTTCKCNPG YFGNGLCCVP DPLDCVHFTG
ICHPNAVCNP DTRQCQCSSG FSGNGVSCFP QKSCRTDKSV CAKNAICLPT GSCICRHGFK
GDPFYKCTSL VAKEPSNAQD LSDVSSCVTP CDASSQLCIS GECICKPGFR QNPGSKTCAD
IDECAEKTHR CNRIATCRNT FGSHVCSCPE GHVGDGVTCV PHVNQGKLSV YCEADGMTLV
LGNETSDFEG KIFVKGQAEN PYCSKSFSAL LNSHKPYVFK VAFQHCDVQL LDNHTMASTV
VVQKHAMFLT NKADSYDLRC QYPIGSRAVQ SHVNVSELAT TSTLTDKNST LAPICRLSVS
NDQHSSISSA MVGDTLKLAL EVTPSENFGI LPRNCFAVNI ESGERYTLTD EQGCAIDESL
FPQWSVTNSA KVQAMFRTFK WPDSSMIRFQ CDCNPCVGQC TVPSCISSSR FRRHHQTTSP
LLNDEIRQEL VLMSGVESLA VSSIINVKDS MSDEDDVVAS ESLTTSSICV KWAPLLIALG
SFVVCSLVLL YLCSKKPKTM DLESEVRF
//