ID A8WQ38_CAEBR Unreviewed; 389 AA.
AC A8WQ38;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Protein CBG01308 {ECO:0000313|EMBL:CAP22596.1};
GN ORFNames=CBG01308 {ECO:0000313|EMBL:CAP22596.1,
GN ECO:0000313|WormBase:CBG01308}, CBG_01308
GN {ECO:0000313|EMBL:CAP22596.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP22596.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP22596.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP22596.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; HE601256; CAP22596.1; -; Genomic_DNA.
DR RefSeq; XP_002636068.1; XM_002636022.1.
DR AlphaFoldDB; A8WQ38; -.
DR MEROPS; A01.A71; -.
DR EnsemblMetazoa; CBG01308.1; CBG01308.1; WBGene00024567.
DR GeneID; 8578063; -.
DR KEGG; cbr:CBG_01308; -.
DR CTD; 8578063; -.
DR WormBase; CBG01308; CBP14039; WBGene00024567; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_3_4_1; -.
DR InParanoid; A8WQ38; -.
DR OMA; NGVGEYE; -.
DR OrthoDB; 2874784at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966:SF45; ASPARTIC PROTEASE 6; 1.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..389
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012700306"
FT DOMAIN 71..384
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 89
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 277
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 102..106
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 389 AA; 41485 MW; B44E56203980618D CRC64;
MKGLILLAIL GLASAAVHQH NIQWRESLRM EMIRNGEYAA YLEYQDTLRR ASPDVLASLQ
ENVNDFGDYE YLGNITIGTP EQSFIVVLDT GSSNLWIPGP TCSTNCQKKH KFDSTKSSTF
VKNGKSWTIQ YGSGDAAGIL GEDTVRFGAA GQPQLPVPKT TFGIASKISA DFKRDATDGI
LGLAFTSLAV DGVVPPLINA INQKLLDQPL FTVWLEHRGA LNNVGGGVFT YGAIDTKNCG
PVVGYQPLSS ATYYQFKVAG FKLGSYSSTK AAEVISDTGT SFIGGPSSVI SGLAKAAGAK
YNALEGAYTI ACNAQPGPLD ITIGSHVYSI QPINYIVNAG NGQCLFAAFH FASGGFGPAW
ILGDPFIRQY CNIYDIGGKR MGFAPSLQK
//
