ID A8WQI7_CAEBR Unreviewed; 643 AA.
AC A8WQI7;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Protein CBG01511 {ECO:0000313|EMBL:CAP22745.2};
GN Name=otpl-7 {ECO:0000313|WormBase:CBG01511};
GN ORFNames=CBG01511 {ECO:0000313|EMBL:CAP22745.2,
GN ECO:0000313|WormBase:CBG01511}, CBG_01511
GN {ECO:0000313|EMBL:CAP22745.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP22745.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP22745.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP22745.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE601420; CAP22745.2; -; Genomic_DNA.
DR AlphaFoldDB; A8WQI7; -.
DR STRING; 6238.A8WQI7; -.
DR WormBase; CBG01511; CBP42068; WBGene00024736; Cbr-otpl-7.
DR eggNOG; KOG4740; Eukaryota.
DR HOGENOM; CLU_011508_3_1_1; -.
DR InParanoid; A8WQI7; -.
DR OMA; FVYHTFE; -.
DR OrthoDB; 2877304at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522:SF29; OTOPETRIN-LIKE; 1.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR Pfam; PF03189; Otopetrin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 64..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 269..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 72226 MW; AC3D23EF5822921F CRC64;
MVKNPNSMLL EPLREKDSIV SVASTSTAPP GHLPSTPLAS PTLSEEPLLD QHPEWIQNPK
ATRFLVGLLT SMYVLLLTIV SCLISLSSAW QSPDLWLAET IFSLLMYGIA ILFFIYTYFM
VIYPKPINAL IMFLNKKRPS WVPRPDRWLI PPPLHNGEGA GTLYLRLGAL LFGTLGSVLW
GCEIYLCFSG ECVHRLVSAK DIAAIIFTFL QMHFIVCNSK ITFHRNNHLA SFGMMHCVAV
NIWTWFSMCL VKAQVKRLKK EKKELEHQKN STASYSESSS SSSSSSSEEL EATTVLEGIV
EVVVEKMKPI MMSTNSSSAK TYSSNNYTTS NHTLLRMQSM ARLGDISSFL LTCLVEYSLI
GAAVCFIIWK YMGATSTEEN VDKRKKKLRM DCTSTTVGLF AGIFFMTAAF VTIGIYTMLY
NKKNYGGSDL ILGIVCLILF CVALIATIFG SWRMRVLQYR LHAHGEVIDE ILLIIGLVGE
LVYCSIGFDM IINGKRTGKD APNLAIAVFT FRIVQVIVQA IYILIASRLR CLSATNAQYQ
PGKQTLTFLI IINITLFVYH VFEGMKNMYG FPSIMENKYF ELLNISSPLV VFYRFHSSAC
LAEIWKHTYS TKHNHHHHNV QSPISSPINS PMSDASHHHQ QLV
//
