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Database: UniProt
Entry: A8WT97_CAEBR
LinkDB: A8WT97_CAEBR
Original site: A8WT97_CAEBR 
ID   A8WT97_CAEBR            Unreviewed;       867 AA.
AC   A8WT97;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=vha-6 {ECO:0000313|WormBase:CBG02894};
GN   Synonyms=Cbr-vha-6 {ECO:0000313|EMBL:CAP23708.1};
GN   ORFNames=CBG02894 {ECO:0000313|WormBase:CBG02894}, CBG_02894
GN   {ECO:0000313|EMBL:CAP23708.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP23708.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP23708.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP23708.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE601438; CAP23708.1; -; Genomic_DNA.
DR   RefSeq; XP_002631118.1; XM_002631072.1.
DR   STRING; 6238.CBG02894; -.
DR   EnsemblMetazoa; CBG02894; CBG02894; WBGene00025861.
DR   GeneID; 8572632; -.
DR   KEGG; cbr:CBG02894; -.
DR   CTD; 8572632; -.
DR   WormBase; CBG02894; CBP06375; WBGene00025861; Cbr-vha-6.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; A8WT97; -.
DR   KO; K02154; -.
DR   OMA; MFLQPEA; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008549};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    437       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    457    475       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    557    576       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    588    612       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    624    644       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    691    710       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    796    820       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   867 AA;  98992 MW;  0228D9CBE89882EE CRC64;
     MGSIYRSEHM KLCQIFFQSE SAYQCVAELG ELGMAQFIDL NEEQNSYQRK FVNEVRRCEE
     MDRKITFVED EINKDLVPIP DYNDHIPAPQ PKHMGEMEAN LEKLEEELLQ INKNTKTLKT
     NHIQLLEMKA VLEHVTSLMD HQSKREAAMS ISEAARGEAG PFSVGLKQEF DKPVRDENEL
     KFVTGVIKRA KSIAFERFLW RLSRAKVFAK FVQIQEKTDL FSHEYEDKCV FILFFSGEQL
     RSKVKKICDG FQAKCYTVPE NPAERTKLLN NIKIQANDMK AVIEKTLDYR AKCIHTAAGN
     LRKWGIMLLK VKSIFHTLNM FSVDVTQKCL IAECWVPEAD IAQVKNSLHM GTIHSGSSVP
     AILNEMETEK YPPTYFKLNK FTQGFQNIVD AYGIASYREV NPAPWTIISF PFLFAVMFGD
     AGHGIIMLLA AAGFVIFEKK LISMKIKDEI FNTFFGGRYV VLLMGMFAIY TGLIYNDFYS
     KSINMFGSSW TNPYPKSLLE QMDKQGAESK TELSLTFPPE NAFDHGYGPY PFGVDPVWNL
     ATNRLNFLNP MKMKTSILLG ISQMAFGILL SLMNHIGNRS VVDIIFVFIP QCLFLGCIFV
     YLCLQVIMKW IFFYVKPAII FGKFYPGSNC APSLLIGLIN MFMVKSRDPT FAFDINNGKG
     KYNATLDDGT KYTYTDYDQC YLQQWYPNQS LVEIILLLIA VVSVPVMLLV KPFYIRWRHS
     RGLPVDLGHG PEDEHGEFNF GDVMVHQAIH TIEFVLGCVS HTASYLRLWA LSLAHAQLSD
     VLWTMVLRMS LKMGGWGGSA AVTIIFYFIF SILSVCILIL MEGLSAFLHA IRLHWVEFQS
     KFYGGTGIQF EPFSFTKIIR VYEGLDQ
//
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