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Database: UniProt
Entry: A8WVD0
LinkDB: A8WVD0
Original site: A8WVD0 
ID   STX1A_CAEBR             Reviewed;         293 AA.
AC   A8WVD0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   29-OCT-2014, entry version 39.
DE   RecName: Full=Syntaxin-1A;
DE   AltName: Full=Uncoordinated protein 64;
GN   Name=unc-64; ORFNames=CBG03570;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Plays a critical role in several secretory processes,
CC       including cuticle secretion and neurotransmitter release, and
CC       probably assists in neuronal membrane maturation or the final
CC       stages of neuronal differentiation. Essential for embryonic
CC       viability and development. Has a role in dauer formation and adult
CC       life span. Required for locomotion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with unc-18. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00202}.
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DR   EMBL; HE601339; CAP24441.1; -; Genomic_DNA.
DR   RefSeq; XP_002647050.1; XM_002647004.1.
DR   ProteinModelPortal; A8WVD0; -.
DR   SMR; A8WVD0; 30-251.
DR   STRING; 6238.CBG03570; -.
DR   EnsemblMetazoa; CBG03570; CBG03570; CBG03570.
DR   GeneID; 8589049; -.
DR   KEGG; cbr:CBG03570; -.
DR   CTD; 8589049; -.
DR   WormBase; CBG03570; CBP06543; WBGene00026410; Cbr-unc-64.
DR   eggNOG; COG5074; -.
DR   HOGENOM; HOG000286023; -.
DR   InParanoid; A8WVD0; -.
DR   KO; K04560; -.
DR   OMA; EHDENQQ; -.
DR   OrthoDB; EOG7X9G7R; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0040011; P:locomotion; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0007269; P:neurotransmitter secretion; ISS:UniProtKB.
DR   GO; GO:0017157; P:regulation of exocytosis; IEA:InterPro.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR   GO; GO:0007268; P:synaptic transmission; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR028669; STX1A/1B.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR006011; Syntaxin_N.
DR   InterPro; IPR010989; t-SNARE.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957:SF84; PTHR19957:SF84; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF00804; Syntaxin; 1.
DR   SMART; SM00503; SynN; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Complete proteome; Cuticle; Developmental protein;
KW   Differentiation; Membrane; Neurogenesis; Neurotransmitter transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    293       Syntaxin-1A.
FT                                /FTId=PRO_0000314060.
FT   TOPO_DOM      1    268       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    269    289       Helical; Anchor for type IV membrane
FT                                protein. {ECO:0000255}.
FT   TOPO_DOM    290    293       Extracellular. {ECO:0000255}.
FT   DOMAIN      195    257       t-SNARE coiled-coil homology.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00202}.
FT   COILED       69     95       {ECO:0000255}.
SQ   SEQUENCE   293 AA;  33576 MW;  E004BF31D9F73B03 CRC64;
     MTKDRLAALK AAQSEDEQDD DMHMETGNAQ YMEEFFEQVE EIRGSVDIIA NNVEEVKKKH
     SAILSNPVND QKTKEELDEL MAVIKRAANK VRGKLKLIEN AIEHDENQQG AGNADLRIRK
     TQHSTLSRRF VEVMTDYNKT QTDYRERCKG RIQRQLDIAG KQVGDEDLEE MIESGNPGVF
     TQGIITDTQQ AKQTLADIEA RHNDIMKLES SIRELHDMFM DMAMLVESQG EMVDRIEYNV
     EHAKEFVDRA VADTKKAVQY QSKARRKKII ILIVVTVIIV ILSLWLIQYI PGI
//
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