ID STX1A_CAEBR Reviewed; 293 AA.
AC A8WVD0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-APR-2013, entry version 31.
DE RecName: Full=Syntaxin-1A;
DE AltName: Full=Uncoordinated protein 64;
GN Name=unc-64; ORFNames=CBG03570;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E.,
RA Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M.,
RA Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for
RT comparative genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Plays a critical role in several secretory processes,
CC including cuticle secretion and neurotransmitter release, and
CC probably assists in neuronal membrane maturation or the final
CC stages of neuronal differentiation. Essential for embryonic
CC viability and development. Has a role in dauer formation and adult
CC life span. Required for locomotion (By similarity).
CC -!- SUBUNIT: Interacts with unc-18 (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane
CC protein (Potential).
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC -!- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
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DR EMBL; HE601339; CAP24441.1; -; Genomic_DNA.
DR RefSeq; XP_002647050.1; XM_002647004.1.
DR ProteinModelPortal; A8WVD0; -.
DR SMR; A8WVD0; 30-251.
DR STRING; 6238.CBG03570; -.
DR EnsemblMetazoa; CBG03570; CBG03570; CBG03570.
DR GeneID; 8589049; -.
DR KEGG; cbr:CBG03570; -.
DR CTD; 8589049; -.
DR WormBase; CBG03570; CBP06543; WBGene00026410; Cbr-unc-64.
DR eggNOG; COG5074; -.
DR HOGENOM; HOG000286023; -.
DR KO; K04560; -.
DR OMA; LIQYIPG; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0040011; P:locomotion; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007269; P:neurotransmitter secretion; ISS:UniProtKB.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR010989; t-SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; t-snare; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil; Complete proteome; Cuticle; Developmental protein;
KW Differentiation; Membrane; Neurogenesis; Neurotransmitter transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 293 Syntaxin-1A.
FT /FTId=PRO_0000314060.
FT TOPO_DOM 1 268 Cytoplasmic (Potential).
FT TRANSMEM 269 289 Helical; Anchor for type IV membrane
FT protein; (Potential).
FT TOPO_DOM 290 293 Extracellular (Potential).
FT DOMAIN 195 257 t-SNARE coiled-coil homology.
FT COILED 69 95 Potential.
SQ SEQUENCE 293 AA; 33576 MW; E004BF31D9F73B03 CRC64;
MTKDRLAALK AAQSEDEQDD DMHMETGNAQ YMEEFFEQVE EIRGSVDIIA NNVEEVKKKH
SAILSNPVND QKTKEELDEL MAVIKRAANK VRGKLKLIEN AIEHDENQQG AGNADLRIRK
TQHSTLSRRF VEVMTDYNKT QTDYRERCKG RIQRQLDIAG KQVGDEDLEE MIESGNPGVF
TQGIITDTQQ AKQTLADIEA RHNDIMKLES SIRELHDMFM DMAMLVESQG EMVDRIEYNV
EHAKEFVDRA VADTKKAVQY QSKARRKKII ILIVVTVIIV ILSLWLIQYI PGI
//
