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Database: UniProt
Entry: A8X399_CAEBR
LinkDB: A8X399_CAEBR
Original site: A8X399_CAEBR 
ID   A8X399_CAEBR            Unreviewed;       953 AA.
AC   A8X399;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   05-JUL-2017, entry version 67.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=unc-32 {ECO:0000313|WormBase:CBG06881a};
GN   Synonyms=Cbr-unc-32 {ECO:0000313|EMBL:CAP27109.2};
GN   ORFNames=CBG06881 {ECO:0000313|WormBase:CBG06881a}, CBG_06881
GN   {ECO:0000313|EMBL:CAP27109.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP27109.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP27109.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP27109.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE601347; CAP27109.2; -; Genomic_DNA.
DR   STRING; 6238.CBG06881; -.
DR   EnsemblMetazoa; CBG06881; CBG06881; WBGene00029076.
DR   WormBase; CBG06881a; CBP44091; WBGene00029076; Cbr-unc-32.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; A8X399; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008549};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    437    461       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    482    500       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    616    636       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    696    715       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    735    756       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    885    912       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      108    142       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   953 AA;  108258 MW;  39038BF7FF9FC9DE CRC64;
     MGDYVTPGEE PQEPGIYRSE QMCLAQLYLQ SDASYQCVAE LGELGLVQFR DVSLNPDVSS
     FQRKYVNEVR RCDEMERKLR FLEREIKKDQ IPMLDTGENP DAPLPREMID LEATFEKLEN
     ELREVNKNEE TLKKNFSELT ELKHILRKTQ TFFEEAGTGE MLPPHEDMIA SSAENSGIGD
     VLSADEEELS ARFSDAMSPL KLQLRFVAGV IQRERLPAFE RLLWRACRGN VFLRTSEIDD
     VLNDTVTGDP VNKCVFIIFF QGDQLKTKVK KICEGFRATL YPCPDTPQER REMSIGVMTR
     IEDLKTVLGQ TQDHRHRVLV AASKNVRMWL TKVRKIKSIY HTLNFFNIDV TQKCLIAEVW
     CPIAELDRIK MALKRGTDES GSQVPSILNR METHEAPPTY NKTNKFTKGF QNIVDAYGIA
     TYREINPSPY TMISFPFLFA VMFGDMGHGV IMFLAALFFI LKEKQLEAAR IKDEIFQTFF
     GGRYVIFLMG VFSIYTGFMY NDIFSKSVNA FGSSWTNSIR HEYIDDVLEK GEKASEAQWM
     LVPELAYDGN PYPIGVDPVW NLAEGNKLSF LNSMKMKMSV LFGIAQMTFG VLLSYKNFTY
     FKSDLDVKYM FIPQMIFLSS IFIYLCIQIL AKWLFFGSAP GSVLGYTYPG TNCAPSLLIG
     LINMFMMKSR NAGFVDEEGN IVPQCWLSTW YPGQSFFETI FVLVAIACVP VMLFAKPYYL
     WKEEKERREG GHRQLATIEI VLVILALVQV PIMLFAKPWL LYQREKKQTR YSTLGGSGGG
     ASTSQSVRAD IAQDDAEVVH APEQTPKPAG HGHGHGDGPL EMGDVMVYQA IHTIEFVLGC
     VSHTASYLRL WALSLAHAQL SDVLWTMVFR NAFVLDGYAG AVATYILFFI FGSLSVFILV
     LMEGLSAFLH ALRLHWQAKK TTVVTFYGGL GYEFAPFSFE RILAEEREAE ENL
//
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