ID A8X4W5_CAEBR Unreviewed; 808 AA.
AC A8X4W5;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Protein CBR-PIX-1 {ECO:0000313|EMBL:CAP27675.1};
GN Name=pix-1 {ECO:0000313|WormBase:CBG07380};
GN Synonyms=Cbr-pix-1 {ECO:0000313|EMBL:CAP27675.1};
GN ORFNames=CBG07380 {ECO:0000313|WormBase:CBG07380}, CBG_07380
GN {ECO:0000313|EMBL:CAP27675.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP27675.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP27675.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP27675.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
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DR EMBL; HE601041; CAP27675.1; -; Genomic_DNA.
DR RefSeq; XP_002645715.1; XM_002645669.1.
DR AlphaFoldDB; A8X4W5; -.
DR STRING; 6238.A8X4W5; -.
DR GeneID; 8587714; -.
DR KEGG; cbr:CBG_07380; -.
DR CTD; 8587714; -.
DR WormBase; CBG07380; CBP40857; WBGene00029444; Cbr-pix-1.
DR eggNOG; KOG2070; Eukaryota.
DR HOGENOM; CLU_018788_1_0_1; -.
DR InParanoid; A8X4W5; -.
DR OMA; IMFFEVT; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019408; 7TM_GPCR_serpentine_rcpt_Srab.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR PANTHER; PTHR46026:SF1; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF10292; 7TM_GPCR_Srab; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 188..247
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 259..436
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 553..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 91504 MW; 64D67E5D02681F83 CRC64;
MDFENFPAEL MSQGSMVIPD TILMILLTIF ILIFSLDIVY ICARQVYIAL TYQNDCDLIF
ETSFCSMFRR VALTCFVGVT STQFCQMLER LIATVLEEKY EFQTQWLGGL FILFSVLSAI
LAIEWALWNE NPLEPMTHCL TYSTSASIGE RMYMVLYGIL FADLFILVAF FALWRKNKQK
VLMEPGSGSP LTARAKFMFE GTNNDELSFD KDAVITITQK LDDGWWEGTH EGVTGWFPSG
YVTLLTEKEI VAIGAQPDYR EAVLKSFIEA EKEYMQKLLK TLQTLLLPIG KSKVLSASDY
CTLVGNYEDI FTLKRDILES LEREQSEDLP KMKVGGVFMK AALELRTSLS LYADNHPDAV
EVLKKKQKDL EKVVKAQDRE YKDLVSGLSE PLRHVDKYYN LLQELERIVP ANHPDRGDLQ
RGAAVFRETK DLCETLRKQK EAQLDFLFVS KVDKVVSPAD RGTILFVALF TKYIMFFEVT
KDMTYDIKEK YPVSGFIVHK KNATEIVFDR PNTGEFTLTM VASGGEVERF MMALGKAGNV
TVIPAPSCTI LRRPSKNTMD NMSQSQGMES PLTSKPPLHP MGISDSGLTT KRKSSSKNFD
DVMNLSNLKL DHELGMVLPE GFELPTSSRN SRNNTDNLQF SQFPAYFLSG NSGKRSERGF
RLRKDAARDE EIEFETLRIL EGYCVETSGA QSDFHANESY QQPHLIVAED EKILMEEMVG
DEMVLQEKLF SPFLGVWGSA AKSIVDAVYS LKDHVMVLQA DLKSLQKAFE SEQKARRRLE
HMLPKMSGVI SPDGSSSTPR KEINSFDS
//
