ID A8X9I8_CAEBR Unreviewed; 527 AA.
AC A8X9I8;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=mut-14 {ECO:0000313|WormBase:CBG09254};
GN Synonyms=Cbr-mut-14 {ECO:0000313|EMBL:CAP29300.1}, smut-1
GN {ECO:0000313|WormBase:CBG09254};
GN ORFNames=CBG09254 {ECO:0000313|WormBase:CBG09254}, CBG_09254
GN {ECO:0000313|EMBL:CAP29300.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP29300.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP29300.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP29300.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|RuleBase:RU000492}.
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DR EMBL; HE600954; CAP29300.1; -; Genomic_DNA.
DR RefSeq; XP_002636810.1; XM_002636764.1.
DR AlphaFoldDB; A8X9I8; -.
DR STRING; 6238.A8X9I8; -.
DR EnsemblMetazoa; CBG09254.1; CBG09254.1; WBGene00030870.
DR GeneID; 8578805; -.
DR KEGG; cbr:CBG_09254; -.
DR CTD; 8578805; -.
DR WormBase; CBG09254; CBP16557; WBGene00030870; Cbr-mut-14.
DR eggNOG; KOG0335; Eukaryota.
DR HOGENOM; CLU_026114_0_0_1; -.
DR InParanoid; A8X9I8; -.
DR OMA; CKKEGPY; -.
DR OrthoDB; 2881113at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007276; P:gamete generation; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF147; MUTATOR; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000492};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT DOMAIN 127..314
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 360..517
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 527 AA; 60285 MW; D2EB5FC56D158B35 CRC64;
MPTPWNKPES DEESPSAIAE PIYEGNVAPL QFDRILNFSE IDQKSYARNV RDRHRDRDVV
ASSKVDSTDI DVFCEENVNV YNHDTTDQPS DYDIEKELRK SLIDERLLNN LQKVKVERLN
AVQRKSIRTV RDGVGLMVEA PTGIGKTYAF LIPAIERAMD ERRKCKTVAT KPSPFVLIMA
NTGTLVKQLF GRCELILGLK CMDGVNPIHD IKVDMLVAEH RFTADSCDIV FCTMGKLKAT
VESGDVLLDN LKMMILDEAD KMIDTAAFGM DVEWILDQMK EEVVRELQSC FFSATFQRDR
DAAITLTPLQ MKMFGGKPWK LVHCPAMPGY ITQHVIRLDR PGRDLTSHTW IKKMNIIRGL
INEDLKTTDC KKEGPYKETI AIFCETIQRV AQVAMALRLL GYNFRPLCRT ITKSQQEVTI
NDLEFKRIHG IVCTNIMSRG IDVSSIKHTI IMEMSSDFDT YKHRIGRVGR DGFGGKATVL
IDHDTLMNPR SAQIVDALYV FMDQCQQPAP QWLKEWFERR HADEQYY
//
