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Database: UniProt
Entry: A8XCW9_CAEBR
LinkDB: A8XCW9_CAEBR
Original site: A8XCW9_CAEBR 
ID   A8XCW9_CAEBR            Unreviewed;       629 AA.
AC   A8XCW9;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   24-JAN-2024, entry version 90.
DE   SubName: Full=Protein CBR-TWK-32 {ECO:0000313|EMBL:CAP30487.2};
GN   Name=twk-32 {ECO:0000313|WormBase:CBG11481};
GN   Synonyms=Cbr-twk-32 {ECO:0000313|EMBL:CAP30487.2};
GN   ORFNames=CBG11481 {ECO:0000313|WormBase:CBG11481}, CBG_11481
GN   {ECO:0000313|EMBL:CAP30487.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP30487.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP30487.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP30487.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
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DR   EMBL; HE600908; CAP30487.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XCW9; -.
DR   STRING; 6238.A8XCW9; -.
DR   WormBase; CBG11481; CBP39768; WBGene00032591; Cbr-twk-32.
DR   eggNOG; KOG1418; Eukaryota.
DR   HOGENOM; CLU_499942_0_0_1; -.
DR   InParanoid; A8XCW9; -.
DR   OMA; FCTELMN; -.
DR   OrthoDB; 2873385at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   PANTHER; PTHR11003:SF73; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR   PROSITE; PS50853; FN3; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857};
KW   Ion transport {ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT   TRANSMEM        33..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        290..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          409..507
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          508..598
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
SQ   SEQUENCE   629 AA;  72258 MW;  0B3287A53D50DF47 CRC64;
     MCGGALLSSG LCRFSELTPG QFGLTKQLVF RLALPHITLL VVSILYAVFG GWMLTLIKYS
     QQTAHQSIVF DQTRQSFAKK LAGIGDKEEF EGIVNELVEK AYEFYTMEDG HRWQEAAFNS
     NPLTNFTSNL FFAATTLTSI GYGIDAPESL VGRVFCLVYL FFGIPLYLIT IADMAKFCTE
     LMNRTYTEII KYKYRVKRRY KRWKSGRIRR YAFPLSIEIN SVYSRESMKV GQVIIAGGED
     EVAEFLWTHL EHAQFVEVPF LLVIGILLLY IGLSSWIISW VENWNMTDGF YFVMMSVLTI
     GFGDLVPRNE IFAVPILFII LAGLVLTTTC VDVVGAYYID RLHFFGRRLD DDPLSWLKEV
     QQRRIEAMKK EAMRKLFETV TALHHIRLTA FKQLTQNYDD HLRSKAPDPP RHLVASHATA
     DSVMLRWSAP IYVDEGKRYW YTITYKPRTP QRRNNVVAVD FINKDRYLVT GLKSFTLYEF
     SVYVTTRYGQ SVPIKVQEYT EPCTVPQSVR IDAISDETAT LSWRAPKMNN GPESYIIQFV
     QEPAPQFVYW NKYRVGSSTR FTLTDLHADT RYIICVTAEH NHGLAAMSKS MRFRTKKWWG
     DEDSTCLRIP GTSHRLSIAS AISTLTALR
//
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