ID A8XCW9_CAEBR Unreviewed; 629 AA.
AC A8XCW9;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 24-JAN-2024, entry version 90.
DE SubName: Full=Protein CBR-TWK-32 {ECO:0000313|EMBL:CAP30487.2};
GN Name=twk-32 {ECO:0000313|WormBase:CBG11481};
GN Synonyms=Cbr-twk-32 {ECO:0000313|EMBL:CAP30487.2};
GN ORFNames=CBG11481 {ECO:0000313|WormBase:CBG11481}, CBG_11481
GN {ECO:0000313|EMBL:CAP30487.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP30487.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP30487.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP30487.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; HE600908; CAP30487.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XCW9; -.
DR STRING; 6238.A8XCW9; -.
DR WormBase; CBG11481; CBP39768; WBGene00032591; Cbr-twk-32.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_499942_0_0_1; -.
DR InParanoid; A8XCW9; -.
DR OMA; FCTELMN; -.
DR OrthoDB; 2873385at2759; -.
DR Proteomes; UP000008549; Chromosome V.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF73; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS50853; FN3; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 33..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..507
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 508..598
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 629 AA; 72258 MW; 0B3287A53D50DF47 CRC64;
MCGGALLSSG LCRFSELTPG QFGLTKQLVF RLALPHITLL VVSILYAVFG GWMLTLIKYS
QQTAHQSIVF DQTRQSFAKK LAGIGDKEEF EGIVNELVEK AYEFYTMEDG HRWQEAAFNS
NPLTNFTSNL FFAATTLTSI GYGIDAPESL VGRVFCLVYL FFGIPLYLIT IADMAKFCTE
LMNRTYTEII KYKYRVKRRY KRWKSGRIRR YAFPLSIEIN SVYSRESMKV GQVIIAGGED
EVAEFLWTHL EHAQFVEVPF LLVIGILLLY IGLSSWIISW VENWNMTDGF YFVMMSVLTI
GFGDLVPRNE IFAVPILFII LAGLVLTTTC VDVVGAYYID RLHFFGRRLD DDPLSWLKEV
QQRRIEAMKK EAMRKLFETV TALHHIRLTA FKQLTQNYDD HLRSKAPDPP RHLVASHATA
DSVMLRWSAP IYVDEGKRYW YTITYKPRTP QRRNNVVAVD FINKDRYLVT GLKSFTLYEF
SVYVTTRYGQ SVPIKVQEYT EPCTVPQSVR IDAISDETAT LSWRAPKMNN GPESYIIQFV
QEPAPQFVYW NKYRVGSSTR FTLTDLHADT RYIICVTAEH NHGLAAMSKS MRFRTKKWWG
DEDSTCLRIP GTSHRLSIAS AISTLTALR
//