ID A8XFA7_CAEBR Unreviewed; 1131 AA.
AC A8XFA7;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Protein CBR-HUM-1 {ECO:0000313|EMBL:CAP31368.2};
GN Name=hum-1 {ECO:0000313|WormBase:CBG12380};
GN Synonyms=Cbr-hum-1 {ECO:0000313|EMBL:CAP31368.2};
GN ORFNames=CBG12380 {ECO:0000313|WormBase:CBG12380}, CBG_12380
GN {ECO:0000313|EMBL:CAP31368.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP31368.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP31368.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP31368.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; HE600913; CAP31368.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XFA7; -.
DR STRING; 6238.A8XFA7; -.
DR WormBase; CBG12380; CBP03005; WBGene00033338; Cbr-hum-1.
DR eggNOG; KOG0162; Eukaryota.
DR HOGENOM; CLU_000192_7_6_1; -.
DR InParanoid; A8XFA7; -.
DR OMA; MAFHWQS; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005902; C:microvillus; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR13140:SF729; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 14..719
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 757..951
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1075..1131
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 596..618
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 949..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1075
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 116..123
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1131 AA; 128488 MW; AEA3CB91B387942F CRC64;
MAFHWQSKVN VQHVGVDDMV LLPKLTEQSI VENLKKRLQA NSIFTYIGPV LISVNPFKQM
PYFTEKEMLL YQGAAQYENA PHIYALADNM YRYRLIKSAF RNMLIDNESQ CVIISGESGA
GKTVNAKFIM NYISRISGGG QKVQVLQHVK DVILQSNPLL EAFGNSATVR NWNSSRFGKY
VEIVFSRGGE PIGGKLSNFL LEKSRVVHQN EGDRNFHIFY QLCAGADKNL RSTLGIGELQ
YYNYLNMSGV FKADDTDDGK EFESTLHALK VVGVNDQEQL EVLRIVSAVL HIGNISFTEE
NNFAAVSGKD CMRLDTNFNF FVTLKIPDLE FPAFLLGLTN ADIESKLTGR KMESKWGTQK
EEIDMKLNVD QANYTRDAWV KAIYARLFDY LVKKVNDALN ITSQSSSDNF SIGILDIYGF
EIFNNNGFEQ FCINFVNEKL QQIFIELTLK AEQEEYVREG IKWTEIDYFD NKIVCDLIEV
KRPPGIMSLL DDTCAQNHGQ REGVDRQLLT TLSKSFAGHP HFGPGSDSFL IKHYAGDVTY
NVDGFCDRNR DVLYPDLILL MQKSSNAFIR SLFPENVAAS AGKRPTTFST KIRTQANTLV
ESLMKCSPHY VRCIKPNETK RPNDWEESRV KHQVEYLGLR ENIRVRRAGF AYRRAFDKFA
QRYAIVSPQT WPSFQGDQQR ACEIICDSVH MEKSQYQMGR TKIFVKNPES LFLLEETRER
KFDGFARVIQ KAWRQFAARK QHIKQKEQAA DLMYGKKERR RYSLNRNFVG DYIGLEHHPT
LQSLVGKRQR ILFACTANKY DRKFRATKLD MLLTANHLFL IGKEKVKSGP EKGKIVEIIK
RQLDLPQIKS IGLSPYQDDF VIIYMNGEEY TSLLETPFKT EFCTALLKAY KERKNSPLHL
DFRDTHVVSY KKMKFDFSDG KRTVQFGCDG SSSAEKTLKP NGKVLNVSIG TGLPNTTRPS
TERPQGGYTP RRDQLRTSTR RTNKNTHGAQ PMRAPVPAHA MNNNYNQPPP HAAAPTPVST
NHQYNQEPAR IPVMGNVISQ LNNMNLAASG NSNPAAGRGP PPARGPKPAP PAKPKLNPVV
IAVYPYEAQD TDELCFEAGD EIELMNKDAS GWWQGKLNNR VGLFPGNYVK E
//
