ID   A8XFZ0_CAEBR            Unreviewed;      1180 AA.
AC   A8XFZ0;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Protein CBG12525 {ECO:0000313|EMBL:CAP31495.1};
GN   Name=tnsl-1 {ECO:0000313|WormBase:CBG12525};
GN   ORFNames=CBG12525 {ECO:0000313|EMBL:CAP31495.1,
GN   ECO:0000313|WormBase:CBG12525}, CBG_12525
GN   {ECO:0000313|EMBL:CAP31495.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP31495.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP31495.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP31495.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
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DR   EMBL; HE600940; CAP31495.1; -; Genomic_DNA.
DR   RefSeq; XP_002640049.1; XM_002640003.1.
DR   AlphaFoldDB; A8XFZ0; -.
DR   STRING; 6238.A8XFZ0; -.
DR   GeneID; 8582044; -.
DR   KEGG; cbr:CBG_12525; -.
DR   CTD; 8582044; -.
DR   WormBase; CBG12525; CBP38121; WBGene00033465; Cbr-tnsl-1.
DR   eggNOG; KOG0504; Eukaryota.
DR   HOGENOM; CLU_007730_0_0_1; -.
DR   InParanoid; A8XFZ0; -.
DR   OMA; CELSHQY; -.
DR   OrthoDB; 2663363at2759; -.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          511..544
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          545..577
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          595..627
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          700..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..729
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..788
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1180 AA;  134818 MW;  C0D750B0BCD33B53 CRC64;
     MSRKIKEAKK YLRNGKFTDA VDKFNEAGHE LYDAGESDQA IEVLEEGAKI AREYKVLLEG
     SLCERKLSEI HAALGNRESS LQHLTAFRNL ATQSGCRSQE QISHHVYAWC LQQLYTNGVA
     GKGDIERAIE MTKKSRELVG TYKKLFKPGD PGGPHHIRLA QLFTLEAQLE NQLGNNEKAL
     HLLDKTDRLL RPNDKSTRFE MLRTKCSIVP VSRRVDIAEL MDDDAPEDKK AQTLCELSHQ
     YILANRLEKG YKSLAQAYIF HEKQLSPTEK EDTTKRLCII YRLVKYSRIL KNTKLEPKLS
     MCELHEAVGD LYDQYFRTLM DKEKKEYRQY IRDNILRNYE KMLECKRNDE DELRAFLGMA
     LVYEDLDEHA KSKNMFEKRL DLLKKTGAAA EKILDTKVSI FGCMCKLKSF GLEKVFDDLS
     KEVEEFDITK RELYDTWANY LLDNGDDEKS QKWRKAADEI PDTLIKDEDD ETDILYGRLP
     DEEILERCRE ENELLKLDNL TEHQKHKTND KGETILHQAA QKSDNEGVVE KLCRMGCKVD
     ARDFGGWTPL SEAVAHDHLE NVRVLIRYGA DVNARSAESF ISEESQSSSD DLNHSKLTPL
     MEACTNGFID IAMLLIDNKA RVDLKDSAGW TAYQHLRRYV NENGGNERMM KFCEYLKNRT
     SQCTDIPALT IRTTNRHEEA HSDDSPPDEI EDNIILGMAA SRKRRNSNNS DNFSNSSKRV
     QRRSGENTRP SPQPPVPSRP FKKRSTQPSM PSYCQPKRLD HRNSSSSLNS IPRGSNSPRR
     SISPTATIRS APSVYADDDD VQVVRMRKVN AIPQIALSSK TSPSVQRLIP SPRAQIDPKS
     TDMIVKCFFQ LPPGNASDEI RPVKLPMRRS LSIAEVKKAV MTSVPTVSLF KIKSVFNKED
     EDKCSIDELT LSQVVHKPDQ REIGLVFELR APPAHEVYEE ISKNPNPEII NELKQLSTAK
     RLDLSSLFLN NLEMSEVAKS LSKCERPQNS YLNISFCGVF PKKMKQIFKI LSMNRTKNKL
     EHLELFGIDF RDEGQILKIL SNCSNVKSLN LSGLNVATHS YNNSLIPATI TAFPNLVKLD
     LSFNSSWISD QNWVQMLKGL EKLEELIINE TNTNVTFETD WLPSLSSFSS RGSDLNWDSI
     FEMLSISEQI SRIDVRFSTC PPILPQELRI GNHRITEILY
//