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Database: UniProt
Entry: A8XGW3_CAEBR
LinkDB: A8XGW3_CAEBR
Original site: A8XGW3_CAEBR 
ID   A8XGW3_CAEBR            Unreviewed;       191 AA.
AC   A8XGW3;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   24-JAN-2024, entry version 97.
DE   RecName: Full=Cell division control protein 42 homolog {ECO:0000256|RuleBase:RU367141};
DE            EC=3.6.5.2 {ECO:0000256|RuleBase:RU367141};
GN   Name=cdc-42 {ECO:0000313|WormBase:CBG13013};
GN   Synonyms=Cbr-cdc-42 {ECO:0000313|EMBL:CAP31887.1};
GN   ORFNames=CBG13013 {ECO:0000313|WormBase:CBG13013}, CBG_13013
GN   {ECO:0000313|EMBL:CAP31887.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP31887.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP31887.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP31887.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Plasma membrane-associated small GTPase which cycles between
CC       an active GTP-bound and an inactive GDP-bound state.
CC       {ECO:0000256|RuleBase:RU367141}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000256|RuleBase:RU367141};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367141};
CC       Lipid-anchor {ECO:0000256|RuleBase:RU367141}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family. CDC42
CC       subfamily. {ECO:0000256|ARBA:ARBA00008112,
CC       ECO:0000256|RuleBase:RU367141}.
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DR   EMBL; HE600938; CAP31887.1; -; Genomic_DNA.
DR   RefSeq; XP_002630566.1; XM_002630520.1.
DR   AlphaFoldDB; A8XGW3; -.
DR   STRING; 6238.A8XGW3; -.
DR   EnsemblMetazoa; CBG13013.1; CBG13013.1; WBGene00033857.
DR   GeneID; 8572082; -.
DR   KEGG; cbr:CBG_13013; -.
DR   CTD; 8572082; -.
DR   WormBase; CBG13013; CBP09230; WBGene00033857; Cbr-cdc-42.
DR   eggNOG; KOG0393; Eukaryota.
DR   HOGENOM; CLU_041217_21_3_1; -.
DR   InParanoid; A8XGW3; -.
DR   OMA; EPKSRRC; -.
DR   OrthoDB; 20499at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR   GO; GO:0005813; C:centrosome; IEA:EnsemblMetazoa.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IEA:EnsemblMetazoa.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0032488; P:Cdc42 protein signal transduction; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0060562; P:epithelial tube morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:EnsemblMetazoa.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:2000370; P:positive regulation of clathrin-dependent endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0110039; P:positive regulation of nematode male tail tip morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0032970; P:regulation of actin filament-based process; IEA:EnsemblMetazoa.
DR   GO; GO:1903358; P:regulation of Golgi organization; IEA:EnsemblMetazoa.
DR   CDD; cd01874; Cdc42; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR037874; Cdc42.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR24072:SF192; CDC42 HOMOLOG; 1.
DR   PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU367141};
KW   GTP-binding {ECO:0000256|RuleBase:RU367141};
KW   Lipoprotein {ECO:0000256|RuleBase:RU367141};
KW   Membrane {ECO:0000256|RuleBase:RU367141};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU367141};
KW   Prenylation {ECO:0000256|RuleBase:RU367141};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549}.
SQ   SEQUENCE   191 AA;  21152 MW;  38B7D5C5CC0FCB70 CRC64;
     MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG
     QEDYDRLRPL SYPQTDVFLV CFSVVAPASF ENVREKWVPE ISHHCSKTPF LLVGTQVDLR
     DDPGMLEKLA KNKQKPVSTD VGEKLAKELK AVKYVECSAL TQKGLKNVFD EAILAALDPP
     QQEKKKKCTI L
//
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