ID   A8XSM2_CAEBR            Unreviewed;      1007 AA.
AC   A8XSM2;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Protein CBG18399 {ECO:0000313|EMBL:CAP35864.2};
GN   Name=tbc-8 {ECO:0000313|WormBase:CBG18399};
GN   ORFNames=CBG18399 {ECO:0000313|EMBL:CAP35864.2,
GN   ECO:0000313|WormBase:CBG18399}, CBG_18399
GN   {ECO:0000313|EMBL:CAP35864.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP35864.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP35864.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP35864.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SIMILARITY: Belongs to the RUTBC family.
CC       {ECO:0000256|ARBA:ARBA00034124}.
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DR   EMBL; HE600936; CAP35864.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XSM2; -.
DR   STRING; 6238.A8XSM2; -.
DR   WormBase; CBG18399; CBP43185; WBGene00037834; Cbr-tbc-8.
DR   eggNOG; KOG1648; Eukaryota.
DR   HOGENOM; CLU_006235_0_0_1; -.
DR   InParanoid; A8XSM2; -.
DR   OMA; LWPKSMR; -.
DR   OrthoDB; 164430at2759; -.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProt.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   CDD; cd15784; PH_RUTBC; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 2.30.29.230; -; 1.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR037745; SGSM1/2.
DR   InterPro; IPR021935; SGSM1/2_RBD.
DR   PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR22957:SF696; TRABUCO, ISOFORM C; 1.
DR   Pfam; PF12068; PH_RBD; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00593; RUN; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT   DOMAIN          131..285
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          671..918
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
SQ   SEQUENCE   1007 AA;  115589 MW;  97EC7E1B2C2AE51A CRC64;
     MQMFRHSSAD VWKAKKPTLE RRSTDGRRSS VVDWINGLSD NNNYKTDLWV EKHDEGCERV
     TRNGSVCAVE ESEPDVPTQH KEVLLTKLKI EIKNIMAEHG AKNYLNLNSP YVTSLCGEYT
     IRKHSGILKF KKSKCLIQFI SVAVDACLMD GLRRRLLTLF NSPSSMSLLQ IIAKSNGSAQ
     QVLDQTKTIE EHHTSVIPVH LIWIREALYM KSLPIIINHF IDSKRAAFKS STVAKTFPAI
     FPSNIVRRYY DSTALLMDPV KGRLVATLLL APCMVTYRRM SSRTQKEATA EELVEGAFRA
     RNGENSGSTS GVGGSRPPLS ITRQVSSIAA SVERNGSVSR DYVFSLHHSC KSTLLYGKNN
     VCVSMNGGDF AKGEPFFLTQ EFQELLNFPG YMSLQKFYDG NLTLKWVPNQ LMHASSQPSS
     GHSNNGEFTN FWKNTINIEM QDIIYIHLHQ KDESSPTCLT FVNCEGVQSA PFQLPAGQHS
     IAFLSSLETG LAPLLRLDPP LWTNLTKEKI LPRLRKRSTA VANPAMLDYV FRLVRTSGVE
     PAPEDIEDPL APSPIPPMHD NCVSLPNSPY IVDNVDSIVN SAPFSFQIGK ACQSMRNQIM
     ARAFYGWLTY VRHLRTIRTH LLHLVDTKTL ICDDDCDPVD EKFWKQCRAE PTKENEEEFL
     KRVYWRGIEG VNSKEIRRMA WPYLLGLFEW NEYPEGRFEQ FTKQYWEDIE EWRVLEAEVR
     RRDEEAFRAA RARRAGSPVR EESCEVFEDP NEPTCSQHYD RENLISLFRA NLHRIDKDVE
     RCDRNLMFFS NKDNLESLRR VMYTYVRRNL EEGYTQGMCD LLAPLLVTFE DEALTLECFS
     ILMIRQRGKF PQRPGMSKCL LNLRSLIQVV DPQIYGLIAD IDYAQALSFA FRWFLLDFKR
     ELSYECTYKV WEVIWAAQRL RITNDFSIFF GLATITNYHD VLITNNFDYT DMIKFFNGKG
     EKKPISFPIC LPLLSSTEMA ERHDCSRLLS SARTHVKCLQ NLVQHLK
//