ID A8XUV4_CAEBR Unreviewed; 1845 AA.
AC A8XUV4;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Protein CBR-TWK-11 {ECO:0000313|EMBL:CAP36424.2};
GN Name=twk-11 {ECO:0000313|WormBase:CBG19123a};
GN Synonyms=Cbr-twk-11 {ECO:0000313|EMBL:CAP36424.2};
GN ORFNames=CBG19123 {ECO:0000313|WormBase:CBG19123a}, CBG_19123
GN {ECO:0000313|EMBL:CAP36424.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP36424.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP36424.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP36424.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; HE601047; CAP36424.2; -; Genomic_DNA.
DR WormBase; CBG19123a; CBP42995; WBGene00038395; Cbr-twk-11.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_001564_0_0_1; -.
DR InParanoid; A8XUV4; -.
DR OMA; EMCEQSA; -.
DR OrthoDB; 2882245at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF61; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..224
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 332..403
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 626..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1447..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1723..1845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..650
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..771
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1470
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1481..1512
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1800..1815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1845 AA; 207388 MW; 544388E183417EAA CRC64;
MSNDNFAIEI DPPDDVEYDI EAGFNSSTCH LMHNFEEERP TSLVASIRES AISSKRKVKY
YCSFFCSPIK KLLSTFKLLI IIGLYSFIGA HLFMYLEVPT DLEAKEDGFH QRKIAREVMV
LKMQRILIIF SLRAIYYDNR DDREERWKHA ILKFEEDMGL EEPVVETDWT FWMSFLYAGT
IFTTIGYGNI ACKTRAGQIA TMVYAFVGIP IMLVMLTSLN NFLLKWIKII TNGLSDILLY
LGVRLGITVI RQDEVQKRLR YTKFAKKMKE WKLSSHGAPS SIAVSFKKTE NIEKLNFQIS
SSEENRLNST PEDDEEEEME LDPPVLSTLF ATVAWIMLSA AVFCLFEDWT FFTSFYFCFI
SLTTIGLGDV TPANPEYMIA TFGVVIVGLS MLTVCIDVIK EKLAQMYMAL LQKLLQEYME
AVKSGDPNAA SAMMAGFQGR AKFLMPLISK NEGAKVMDKF KQDCTKKGID PPPVLTNINP
ETGMPAFANA PREDFRDYID VAQEMFAEEQ QRLTQTPLSK STDFFQSPTP RPTVTVAVTQ
TSAPPPTKSL EVQAGTTMGK FHDYGSQTQT ESSDEGIQTD YSVDFDDEMN KEPKKVMADA
GTQYEIVLLT SIGIQPEVSS IYIGAEQSDH SDEESAFESE DEDDFSEYSS CDDESELKSS
AKYKETSLPF EVEHPGMMSL GLQSPPIEIT PFSDDESALS EARSSPASTS SKPMKLSPPK
FSKSASIDST ETVIHVKPEE KEKKEEERKE ESTHEKKKRR KKRKRMKTKK SREHELRFLK
NSGNQTSPVL MDCSTQYEVF TTDSGSQYDV KGRSRKCQTK LSSINHEQLQ GIRETVQKLK
RRESEMSRAS NVSESDWDSE AGRESEVAEI SLDLSVVALG VDETGRVVEV PKPSKPQESL
SPTSLRTTSE STSAEKVHID SEDEEIESLD ELELYTTDAG MQTEPKMMVD QQDFATPKSL
DIIKNCSTQT TFSTFHLPQK VYESASTSSD EEDVKSESDK DKKSENEVFF MTNAGVQTMH
TSFHLEDKPK IVEEEKLQKE EKTDMEEMPL FLKNSECQTF ELEMLTCSTS TEDVRFVGDA
ETSDGYCQTA LETKNFEVQT VVKDYLETTM QTEDPSLVTD ACQTESIEGT TVHSQTDAPN
TRSFICQTES AVEPEVPPVP SVESVPVECQ TDTLDLEEIE VQTEIETSVT ESQTENAIVD
DVEMQTELTE TITSESQTEK VTVGDLEMQT DQTENTTSES QTEGMVVGDV EMQTEQVETI
ASESQTEQHS VGDIEMQTDE KDTLASTSQT EQLSIEFQET QTDEVTFSRE VPLVDQITQS
ETAEFHDSET QYTLSIEDRD VQVTPISFET QTQHSIEIEV KSCQTEGVRM KNKKSQVEDD
STLSILKIDN ESQIEVDTSS INLSPVRLDV SHSFTMTEPG ALEEKEVQVD EDCFEREETS
QRFFAGPLWS DFDYTPEFGE EGDDEEVVDG ETQTHDGSEP KELEEDEEEE EEEEEEVEEE
YYEEVEVDDD GNEIEGGIVK KEGVEEIEDD IEKKAKAEAD GADASLKSAE DPSSKATKKF
KKVIKKRIVK RLKSKSEAQL ASAQRSTDSL ADSVADEFAV QCSPESSEIK IQTVKFKKKK
KTLKTTEPKV EMSTSTVQAT IEMCEQSAGD VEDDWLQVNV NAGITTSTSL LQKLYTLFYT
LLSAQLSHVY VQELDEERRM RMSDIGIQTG VLARVQHIYT RPISDDAGSS SSTAPITLRK
SSDSDVEHVP MRTAKSSEES LAPSASGTAI SAAESMDDRL WPERASPFAS RHSSLKRRKK
EERKTSDKTN IVQDLRARFE SKSPAPKSPP KEEGEGSSSD PKQFF
//
