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Database: UniProt
Entry: A8Y2W8_CAEBR
LinkDB: A8Y2W8_CAEBR
Original site: A8Y2W8_CAEBR 
ID   A8Y2W8_CAEBR            Unreviewed;       593 AA.
AC   A8Y2W8;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   24-JAN-2024, entry version 108.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   Name=dhhc-14 {ECO:0000313|WormBase:CBG22799};
GN   Synonyms=Cbr-tag-233 {ECO:0000313|EMBL:CAP39302.2}, tag-233
GN   {ECO:0000313|WormBase:CBG22799};
GN   ORFNames=CBG22799 {ECO:0000313|WormBase:CBG22799}, CBG_22799
GN   {ECO:0000313|EMBL:CAP39302.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP39302.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP39302.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP39302.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       AKR/ZDHHC17 subfamily. {ECO:0000256|ARBA:ARBA00010104}.
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DR   EMBL; HE601156; CAP39302.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8Y2W8; -.
DR   STRING; 6238.A8Y2W8; -.
DR   WormBase; CBG22799; CBP41123; WBGene00041272; Cbr-dhhc-14.
DR   eggNOG; KOG0509; Eukaryota.
DR   eggNOG; KOG1311; Eukaryota.
DR   HOGENOM; CLU_012510_3_1_1; -.
DR   InParanoid; A8Y2W8; -.
DR   OMA; RCHNLLE; -.
DR   OrthoDB; 33889at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016409; F:palmitoyltransferase activity; IBA:GO_Central.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR24161:SF108; PALMITOYLTRANSFERASE HIP14; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13857; Ank_5; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Membrane {ECO:0000256|RuleBase:RU079119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        309..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        337..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        460..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        499..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   REPEAT          54..86
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          88..120
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          121..154
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          190..222
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          411..549
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
SQ   SEQUENCE   593 AA;  66777 MW;  AC09C632CF2C8758 CRC64;
     MDGDTEVLTH NMRPPAVIDV FNLHAVISAT QHGQADLVRE ALKQGVSPNA TDDDGCSLLH
     WAAINNRLEV ARLLISYNAD TNLVGGVLAS SPIHWAARNG LVAMCAMLVK AGAVCNIRDI
     QGYTPIHLAI QGNHIGLVAY FLLKFDYAKD ISDNSGMTPA MLCAKKSYTM FPLRLIVRAG
     ADLSLKEHFS GNTALHLAAH DRNSSAVIEL LQGNADVNIR NKQSETPLDM ARAIKNPHIL
     GDSLSIYQKH TKLSLITEMM EEAARKQGVS RTSCFRKCFV PPLSTYFFFM VPMFGFFITY
     LLFKYLPLVV ATFTTLISCI FLMVLIRFDY HDPTYKLLPY GVTIAEALLM IFSWTAYAHW
     FVPWWAQMLF VLSVIALGFT LFRIGTVDPG IVKAPKNCHQ LYVNEAEAGI QHQHKYCFTC
     FIRKLEHTKH CAVCGFCVNN FDHHCPWLNS CVTRRNMREF IMFIISVAVS SFIYCVATTH
     YAVMKIDENG LEKFLETEAF LMITIILSAM HAFMLAVLFC VQLNQKIDSQ ALKMSKKKTI
     SQGVTTNERI KARRAGHHHS HNSDYNVIHH RPSVSKRCHN LLEFFSSNGD PNW
//
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