ID A8ZY58_DESOH Unreviewed; 490 AA.
AC A8ZY58;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Dole_1259 {ECO:0000313|EMBL:ABW67065.1};
OS Desulfosudis oleivorans (strain DSM 6200 / JCM 39069 / Hxd3) (Desulfococcus
OS oleovorans).
OC Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC Desulfosudaceae; Desulfosudis.
OX NCBI_TaxID=96561 {ECO:0000313|EMBL:ABW67065.1, ECO:0000313|Proteomes:UP000008561};
RN [1] {ECO:0000313|EMBL:ABW67065.1, ECO:0000313|Proteomes:UP000008561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6200 / JCM 39069 / Hxd3
RC {ECO:0000313|Proteomes:UP000008561};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Wawrik B.,
RA Richardson P.;
RT "Complete sequence of Desulfococcus oleovorans Hxd3.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP000859; ABW67065.1; -; Genomic_DNA.
DR RefSeq; WP_012174682.1; NC_009943.1.
DR AlphaFoldDB; A8ZY58; -.
DR SMR; A8ZY58; -.
DR STRING; 96561.Dole_1259; -.
DR REBASE; 16467; M.DolHORF1259P.
DR KEGG; dol:Dole_1259; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_018284_4_0_7; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000008561; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF4; TYPE I RESTRICTION ENZYME ECOKI METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ABW67065.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008561};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 13..140
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 154..459
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 463..490
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 490 AA; 55844 MW; A8CB48E898C66455 CRC64;
MTSKIDHRRQ EVQQIVKNAC DQLNQEGVDA RNYVEQLAWL FFLKAFDEAE TRREQEADFD
DTAYGRRLSG QYAWSSWARN TDHPDQMLEF VDGKLWIKLT SPDPQKGLGD DLLAQRFRRI
FDNVRNYCRR GISFARVVQQ VDKLHFSSET DVIVLSEIYE DLLKRVAADS AGYAGEFYTQ
RHIIRAMVEV VQPKPKDKVY DPCFGTAGFL GEAADYIRRN NTLSGPQLDA LQKKTFYGLE
IKPLTYLLGT MNMILHGIEG ANLELTNTLE IHSQNVGEKA RYDVILSNPP YGGKMASGMQ
TNFRVRSSAT ECLFLQHIMA NLAKGGRAGV VIPEGVLFRG GPDQKVRKEL LEQFNVHTIL
SLPAGCFLPY TGVKTNVIFF DRPKDDSGTK SVWFCELTND GFELKSTRKP IEGDQLPDFL
AKWEKRKAGD NSWTVPIEKI IEQGYDLSAK NPNRKDEYEH RPALELVQSI KAKEERIMDL
LNELEGILEK
//
