ID A9B7X4_HERA2 Unreviewed; 2596 AA.
AC A9B7X4;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Amino acid adenylation domain {ECO:0000313|EMBL:ABX04502.1};
GN OrderedLocusNames=Haur_1859 {ECO:0000313|EMBL:ABX04502.1};
OS Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95).
OC Bacteria; Chloroflexota; Chloroflexia; Herpetosiphonales;
OC Herpetosiphonaceae; Herpetosiphon.
OX NCBI_TaxID=316274 {ECO:0000313|EMBL:ABX04502.1, ECO:0000313|Proteomes:UP000000787};
RN [1] {ECO:0000313|Proteomes:UP000000787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23779 / DSM 785 / 114-95
RC {ECO:0000313|Proteomes:UP000000787};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA Bryant D.A., Richardson P.;
RT "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABX04502.1, ECO:0000313|Proteomes:UP000000787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23779 / DSM 785 / 114-95
RC {ECO:0000313|Proteomes:UP000000787};
RX PubMed=22675585; DOI=10.4056/sigs.2194987;
RA Kiss H., Nett M., Domin N., Martin K., Maresca J.A., Copeland A.,
RA Lapidus A., Lucas S., Berry K.W., Glavina Del Rio T., Dalin E., Tice H.,
RA Pitluck S., Richardson P., Bruce D., Goodwin L., Han C., Detter J.C.,
RA Schmutz J., Brettin T., Land M., Hauser L., Kyrpides N.C., Ivanova N.,
RA Goker M., Woyke T., Klenk H.P., Bryant D.A.;
RT "Complete genome sequence of the filamentous gliding predatory bacterium
RT Herpetosiphon aurantiacus type strain (114-95(T)).";
RL Stand. Genomic Sci. 5:356-370(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP000875; ABX04502.1; -; Genomic_DNA.
DR STRING; 316274.Haur_1859; -.
DR KEGG; hau:Haur_1859; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_8_0; -.
DR InParanoid; A9B7X4; -.
DR BioCyc; HAUR316274:GHYA-1888-MONOMER; -.
DR Proteomes; UP000000787; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19543; DCL_NRPS; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 981..1055
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2483..2558
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2566..2596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2566..2587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2596 AA; 289408 MW; D0D6897253395F64 CRC64;
MDNIQDIYEL SPMQQGMLFH TIASPTAGMY LEQVQSRLRG QLDLACFRQA WHMVVARHTI
LRSGFFWEEL EKPLQVVYEA VELPFQVLDW RTLSAAQQAY ELDILLENDR QQPFALDQAP
LQRWVVVQLA DDQWHWVWTF HHLLLDGWSV ALLFEEVLQH YAALRRGTTL NQAPAPAYRA
YIDWLQQHDQ AQAEQFWRGY LADFSYPTPL PLQRSSQRSM SQRFAEYNQQ LTSAETSQLQ
SWARQSQVTL NTCVQAAWAY LLAQHSQTND VVFGATFAER PAEIYQSEQL IGLCINTLPI
RAKCEPSQSP QTWLQTLQAA YGELQQHSAS ALVDIQRWSE LAHGSSLFES IVVFENYPLQ
ATDASQAGLQ IEQLSLAEHT NYPVTLIVVP GEQLRLSLSV DHDRYDQASA ELLLAQLQRI
LLSLTTASSV AELSLVTPNQ RANLQAWGNW QAPNYAPPLC LHEWFAQQVQ AHPKAKALSF
EDTWLSYAEL DQRSNQVAHG LIAQGVTVGN LVGLCVERSL ELVVGILAIL KAGAAYVPLD
PTYPRERLAF VQADAAIRHI VTQRHLRDVV QAEQCYLLDQ PMDAYPTTPP SVVCSTENPA
YVIYTSGSTG NPKGVVVSHA NVARLMLATN AWYQFNQHDV WTLFHSYAFD FSVWELWGAL
LYGGHLVVVP YWVSRNPEAF HQLLRQQHVT VLNQTPSAFY QLIQADSLAE QRLALRTVIF
GGEALDLAQL APWFARYGDQ QPQLVNMYGI TETTVHVTYR PIRLADLQAG LGSVIGCPIP
DLALAVLDAQ GRQAGVGVAG ELYVGGAGVA QGYLERPELN AQRFIQADAS TPDLPSNSRW
YRSGDLVRYW PNGELEYLGR IDLQVKIRGF RIELGEIEAA LSQHAAVQSA AVIVREDRPG
HKRLVGYLIA KTQMRSVGAQ TDPSLDLAAI NQQLRERLPE YMWPSALIEL ASFPLTSNGK
LDRQALPAPE AEQATPTSST PLQSPLEQQL ADLWSVALGQ TIASREVNFF SLGGDSIIAM
QVVSRARAAG LNLSPRQLFQ HQTIAELALM LEQQASSLAL EQPSYQLEGE IAWTSIGHWL
RELRPNNPQH FNQSLMLVVA PDLAPAAIQA ALDRLVSLHP ILRVRWQFEP QQRQWYGDSR
SINVAVQHCA DDSNNWPTML GHICQRMQQH LHLEHGPSFA ATLVRTPTQA RLILVAHHLV
IDGVSWRIVL EDLAMALNGA AAIPSTTPWS VWANRLQAEA THPQYLADLS FWQQQIANIS
PVPLDHVPNS GQNLTRDAVF VHTTLDQVTT QALLHDCQQA VRVNINDLLL TALTQTLAGW
AEQRHWVIDL ESHGRFSPEP SDDLSRSVGW FTSLYPVALD LPADPAPLAA LKAIKEQLRA
VPAGGQSFGI LRYLNSATAP QLQPTQAVPL VFNYLGQLDQ SVSMPPLLGI APESTGADVA
ASTPRGHLLN VASYIRDGQL QFDWEYNQTW HQQQTIERLA SACVAALKAL IGACRQQLRL
SLTPSDVALA KLDQPTLDQL LARYHGQNLT PVDVYPLAPL QVGMLYHSLL NPQSSVYLEQ
VEWTVNGPLD LVSLQIAWQQ VQQRHAVLRT AFCTEGLPQP LQIVLEHVDT PWRVLDWQAI
APDEQAELLA ALREADRTQP FSLTQAPLLR WTWIKLAEQR YHCLWTHHHL LLDGWSIANV
LAELFGIYGH VDQAQPLQLA PAVAYRDYIA WATSYDQQQA QQFWRDYLAD LTEPTPLPAP
HAAPQATSGY HEYSLQLTPS QTQALQQWAR QQHVTLNTLV QGAWAVLLGR YNALDDVLFG
ATVAGRPTDI AGMEHLVGLC INSLPVRVKL DSQQPIVAWL QALQAQQSRC NDFAATPLTT
IQQASQIPAS QHLFETLLVF ENYPIAASVE QAVSDLAIVD AKTTEQTNLP LTLLVLPDAA
LTLKLSYDQA VYSTTRIAQL ARHLAHVLQQ LPLATTVGEL SVLDAAEQAQ LLNEWNNTAQ
IWDSSELLVD VLAQQVQRTP NAPALSDEHH HYSYAELDQR VTQLAASLQA HGVQVDDRVG
VLMERSAQLV IALLAIVKAG AAYVPFDPAY PSERVLAMLA DAAPRVVITD TPKLGQATIP
VLLFDQAWQP NHSLSFNPPI IHPLNAAYMI YTSGSTGKPK GVINSHQAIV NRLLWMQQRY
QLTAADVVLQ KTPYSFDVSV WEFFWPLMTG AKLVVARPAG HLDRRYLAET IQAQKVTTIH
FVPSMLSLFL EEPQAANCTS LRQVFCSGEA LSAETSARFC QTLNADLHNL YGPTEAAVDV
SAWHYQPNAE PSVPIGRPIA NTQLYILDAR MQPVPVGVAG ELLIGGLNLA RGYAERPDLT
AERFIPHPYA SQAGARLYRT GDLARWRDDG AIEYLGRNDF QIKVRGIRVE LGEIEHQLSQ
HPAIAQIVVH HHAGQLVAYW VARPDQAVPE ETALRSWLRA RLPEAMIPAH WLQLAELPLS
SNGKLNRKAL PTPQLGAETP QRQPQNALEQ TIAAIWSVVL ERPINQVERP FFDLGGHSLA
LIQVHSRLET ALNRSIELML LFEHPTIAAL AVALSEQPSE LTPTIEDQVH QRSQRQQSQA
QRRQRRQQVQ LNLDEE
//
