ID A9BAQ3_PROM4 Unreviewed; 344 AA.
AC A9BAQ3;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Putative cobalamin synthesis protein {ECO:0000313|EMBL:ABX08915.1};
GN Name=cobW {ECO:0000313|EMBL:ABX08915.1};
GN OrderedLocusNames=P9211_09841 {ECO:0000313|EMBL:ABX08915.1};
OS Prochlorococcus marinus (strain MIT 9211).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=93059 {ECO:0000313|EMBL:ABX08915.1, ECO:0000313|Proteomes:UP000000788};
RN [1] {ECO:0000313|EMBL:ABX08915.1, ECO:0000313|Proteomes:UP000000788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9211 {ECO:0000313|Proteomes:UP000000788};
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP000878; ABX08915.1; -; Genomic_DNA.
DR RefSeq; WP_012195536.1; NC_009976.1.
DR AlphaFoldDB; A9BAQ3; -.
DR STRING; 93059.P9211_09841; -.
DR KEGG; pmj:P9211_09841; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_1_0_3; -.
DR OrthoDB; 517607at2; -.
DR Proteomes; UP000000788; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012824; CobW.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02475; CobW; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000788}.
FT DOMAIN 6..211
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT DOMAIN 268..323
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07683"
SQ SEQUENCE 344 AA; 38325 MW; 1F999BB21247DDDF CRC64;
MSKRLPVTVV TGFLGSGKTT LLRYLLRNSN LRLAFIINEF GSVGLDGDLI KSCGICPEDE
IQERLVELNN GCLCCTVQED FLPTMEALLS KSDSLDGIIV ETSGLALPKP LLQALDWPEI
RTRLFVNGLV TMVDSEALSF GSPVSDLLAL QKQRDADDSI DHLTPVNELY EDQLKVADLV
LLSRSDLLSK NTLESIRLET LKKVRDGTPI LPISNGQIDP SIILGIRNSD SLPNFFDNKN
NHDDHSHLDV FSNHIRLETD IDISIFQEKI APLVSEFQIL RLKGRIWVKG KILPLQVQMV
GSRFDSWFEK APSQSWQPKQ SGIDIVVLSL KDGIEDSFTK SLSQ
//
