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Database: UniProt
Entry: A9CWQ0_HOEPD
LinkDB: A9CWQ0_HOEPD
Original site: A9CWQ0_HOEPD 
ID   A9CWQ0_HOEPD            Unreviewed;       485 AA.
AC   A9CWQ0;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   05-JUL-2017, entry version 65.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HPDFL43_20192 {ECO:0000313|EMBL:EDQ35551.1};
OS   Hoeflea phototrophica (strain DSM 17068 / NCIMB 14078 / DFL-43).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Hoeflea.
OX   NCBI_TaxID=411684 {ECO:0000313|EMBL:EDQ35551.1, ECO:0000313|Proteomes:UP000004291};
RN   [1] {ECO:0000313|EMBL:EDQ35551.1, ECO:0000313|Proteomes:UP000004291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DFL-43 {ECO:0000313|EMBL:EDQ35551.1,
RC   ECO:0000313|Proteomes:UP000004291};
RA   Wagner-Dobler I., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDQ35551.1, ECO:0000313|Proteomes:UP000004291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DFL-43 {ECO:0000313|EMBL:EDQ35551.1,
RC   ECO:0000313|Proteomes:UP000004291};
RA   Fiebig A.;
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EDQ35551.1}.
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DR   EMBL; ABIA03000001; EDQ35551.1; -; Genomic_DNA.
DR   ProteinModelPortal; A9CWQ0; -.
DR   STRING; 411684.HPDFL43_20192; -.
DR   EnsemblBacteria; EDQ35551; EDQ35551; HPDFL43_20192.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004291; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004291};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004291}.
FT   DOMAIN      178    306       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      393    462       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     186    193       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   485 AA;  54081 MW;  51BEAC546DF27B2C CRC64;
     MKKTNDVFER VMARLKAQVG QEIFTSWFGR LKLQSASKSV VRLSVPTAFL KSWINNKYLD
     QISALYREEA PDVLKIEIVV RSATRSTAVS SAPDAASLPN ASQATPGASA SRKEQHVTVK
     GAGAKFGAFN KGPQAANAVI GSPLDPQCTF DSYVEGSSNR VALAAARTIA EAGTGAVRFN
     PLFIHSNVGL GKTHLLQAIA AAASSHSRNP RVVYLTAEYF MWRFATAIRD NDALSFKESL
     RNIDLLVIDD MQFLQGKSIQ HEFCHLLNML LDSARQVVVA ADRAPWELES LDPRVRSRLQ
     GGVAIEIEAP DYEMRLEILR KRLAIAQMED ATLDIDETIL AHVAQNITSS GRELEGAFNQ
     LLFRRSFEPN LSIERVDELL GHLVNAGEPK RVRIEDIQRV VSRHYNVTRQ ELVSDRRTRV
     IVKPRQIAMY LAKTMTPRSF PEIGRRFGGR DHTTVLHAVR KIEELINGDT KLGHEIELLK
     RLIIE
//
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