ID A9CY88_9GAMM Unreviewed; 391 AA.
AC A9CY88;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Multidrug resistance protein, AcrA/AcrE family {ECO:0000313|EMBL:EDQ02430.1};
GN ORFNames=KT99_02917 {ECO:0000313|EMBL:EDQ02430.1};
OS Shewanella benthica KT99.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=314608 {ECO:0000313|EMBL:EDQ02430.1, ECO:0000313|Proteomes:UP000005839};
RN [1] {ECO:0000313|EMBL:EDQ02430.1, ECO:0000313|Proteomes:UP000005839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT99 {ECO:0000313|EMBL:EDQ02430.1,
RC ECO:0000313|Proteomes:UP000005839};
RA Yayanos A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDQ02430.1}.
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DR EMBL; ABIC01000003; EDQ02430.1; -; Genomic_DNA.
DR RefSeq; WP_005496460.1; NZ_ABIC01000003.1.
DR AlphaFoldDB; A9CY88; -.
DR STRING; 314608.KT99_02917; -.
DR Proteomes; UP000005839; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 37..356
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 63..289
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 391 AA; 41351 MW; 7070641F05E2D398 CRC64;
MRQIVKIASF LSVALWITAC GQNGDSKQGR GPGIAEVGVI TIKTQSQDIQ IELPGRSKAF
LEAEVRPQAS GIITERTFVE GSDVNKGQSL YQIDSATYKA AVISAEAELA SANAGLVSAK
AKAARFKELI KTNAISQQDF DEADALYKEA LANVVVAKAA INTAKINLVY TEVKAPISGR
ISKSSVTAGA LVTANQSQIL AKIQQLDPIN VDIAQSSAQL LRLKAKLRQG KLQAADNADV
QLILEDGTTY AHTGVLRFAE VSVDENTGSV TLRAEFPNPD GLLLPGMYVR AVLNAGTDPQ
AILVPQKAIT RNTKGQAVAM LVNSENKVES RVVITAEVID HQWRITDGLA VGDVLIVEGL
QKIRPGASVK SVAVTADDSA STPASQSANQ K
//
