ID   A9D0X1_HOEPD            Unreviewed;       309 AA.
AC   A9D0X1;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Dihydrodipicolinate synthase/N-acetylneuraminate lyase {ECO:0000313|EMBL:EDQ35078.2};
DE            EC=4.3.3.7 {ECO:0000313|EMBL:EDQ35078.2};
GN   ORFNames=HPDFL43_02735 {ECO:0000313|EMBL:EDQ35078.2};
OS   Hoeflea phototrophica (strain DSM 17068 / NCIMB 14078 / DFL-43).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Hoeflea.
OX   NCBI_TaxID=411684 {ECO:0000313|EMBL:EDQ35078.2, ECO:0000313|Proteomes:UP000004291};
RN   [1] {ECO:0000313|EMBL:EDQ35078.2, ECO:0000313|Proteomes:UP000004291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DFL-43 {ECO:0000313|EMBL:EDQ35078.2,
RC   ECO:0000313|Proteomes:UP000004291};
RA   Wagner-Dobler I., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDQ35078.2, ECO:0000313|Proteomes:UP000004291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DFL-43 {ECO:0000313|EMBL:EDQ35078.2,
RC   ECO:0000313|Proteomes:UP000004291};
RA   Fiebig A.;
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDQ35078.2}.
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DR   EMBL; ABIA03000002; EDQ35078.2; -; Genomic_DNA.
DR   RefSeq; WP_040449090.1; NZ_CM002917.1.
DR   AlphaFoldDB; A9D0X1; -.
DR   STRING; 411684.HPDFL43_02735; -.
DR   eggNOG; COG0329; Bacteria.
DR   HOGENOM; CLU_049343_2_0_5; -.
DR   OrthoDB; 199953at2; -.
DR   Proteomes; UP000004291; Chromosome.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IEA:UniProtKB-EC.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004291}.
FT   ACT_SITE        141
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        169
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
SQ   SEQUENCE   309 AA;  34394 MW;  16DB77F936BDD0A6 CRC64;
     MPHAMQGVFP VMITPFRPDN TVDWEGYARL IEWYLDNGSH GLFAVCQSSE MQFLSLEERR
     ELARFTVEQV AGRVPVVASG HISDSISDQK EELLTIAGTG VDAVVLVTNR LAAANEDSSA
     FQSRMDALLE ALPADLMLGL YECPAPYRRL LTDEEVSWCA HSGRFAFLKD VTCNLEHLKR
     RLALVAGTPL AINNANAAIA WPAIQAGGHG FSGVMNNFHP DLYRWLIDHG QAHPEFAAEL
     DTFLVLAAMS ESLGYPKLAK HFHRRIGTFA SVHSRSVNYD IDERHWAADV VLDQILEGAD
     RLRNRIRSL
//