ID A9ELS1_SIV Unreviewed; 220 AA.
AC A9ELS1;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:CAN85199.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:CAN85199.1};
OS Simian immunodeficiency virus - wrc.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC Simian immunodeficiency virus.
OX NCBI_TaxID=446034 {ECO:0000313|EMBL:CAN85199.1};
RN [1] {ECO:0000313|EMBL:CAN85199.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wrc {ECO:0000313|EMBL:CAN85199.1};
RX PubMed=17916449; DOI=10.1016/j.meegid.2007.08.004;
RA Locatelli S., Liegeois F., Lafay B., Roeder A.D., Bruford M.W.,
RA Formenty P., Noe R., Delaporte E., Peeters M.;
RT "Prevalence and genetic diversity of simian immunodeficiency virus
RT infection in wild-living red colobus monkeys (Piliocolobus badius badius)
RT from the Tai forest, Cote d'Ivoire SIVwrc in wild-living western red
RT colobus monkeys.";
RL Infect. Genet. Evol. 8:1-14(2008).
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DR EMBL; AM743113; CAN85199.1; -; Genomic_DNA.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00075; RNase_H; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00023247};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 1..94
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 101..142
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 144..220
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAN85199.1"
FT NON_TER 220
FT /evidence="ECO:0000313|EMBL:CAN85199.1"
SQ SEQUENCE 220 AA; 24586 MW; D58D9EE5FF98E2E9 CRC64;
IKRLSLQNTT NQQAELTALK LALEDGGEKM NIITDSQYVM GIVKDHPTIS ESPLVQEIIE
LLKRKEEIYI EWVPAHKGIG GNTEIDKLVS AGIRSKIMFL ENITPAIDSH TKYHQGWKSL
QEEFHLPQML AKRIVEECAT CQGKGGAPIH GMVDYSIGTW QMDCTHLEGK IILNAVHVAS
GYLEAKIIPT EDAYQTALFT LQLASRWPVK KIHTDNGTNL
//
