ID A9FYH6_SORC5 Unreviewed; 2018 AA.
AC A9FYH6;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 105.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=sce5457 {ECO:0000313|EMBL:CAN95620.1};
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN95620.1, ECO:0000313|Proteomes:UP000002139};
RN [1] {ECO:0000313|EMBL:CAN95620.1, ECO:0000313|Proteomes:UP000002139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; AM746676; CAN95620.1; -; Genomic_DNA.
DR RefSeq; WP_012238088.1; NC_010162.1.
DR STRING; 448385.sce5457; -.
DR KEGG; scl:sce5457; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR eggNOG; COG3899; Bacteria.
DR HOGENOM; CLU_000445_34_2_7; -.
DR OrthoDB; 5521237at2; -.
DR BioCyc; SCEL448385:SCE_RS27995-MONOMER; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF01590; GAF; 2.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CAN95620.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002139};
KW Transferase {ECO:0000313|EMBL:CAN95620.1}.
FT DOMAIN 7..274
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1494..1564
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1777..1997
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 1470..1504
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2018 AA; 222081 MW; C7BB28929CEAF42A CRC64;
MPESPRYLVV GVLHQGAETI LYRARRAEDG RPVVLKVLRR DHASPRALGR LRHEHELARA
LDTTAVVKAR AIEVFGDQVA LVLEDFGGRS LDRLLDGDGP MRPMRPMSIE RFVPLALRLT
DALAELHRHR IIHKDIKPQN LLCNPDTGEV KITDLGIACL LPRESQDLAR DRLIEGTLAY
MAPEQTGRMN RWIDERTDLY SLGVTFYQML TGALPFQASD PVEWVHCHIA QAPRPPHALV
PSIPPLLSAV VLKLLSKAAE ERYQSALGLR HDLDRCSSQL RATGAIEPFP LGERDLSDRF
RVPQRLCGRE REIEALLAAF ERVVSNGRPE LALVSGYSGI GKSSLVAELH RPVVRERGFF
VSGKFEQLKR DVPYHAFLQA FRALLQEILC ASEEQLERWR LRLREALGQE GGLLADVLPE
LALLLGPQPP VPELPPAEAQ GRLHAALQRF VAACARNEHP VALFLDDLQW ADAASLLLLE
QLATYTGSEH LLLIGAYRDN EVGPAHPLRL TLAEVQKRGA AVSELVLAPL SAAHVGALVA
EAVHARTEEV EPLSRLVHEK TGGNPFFVLQ FLFELHQEGL ITFDAEQRAW RWDIAAIHDK
GFTDNVVELM VGKLKRLSLP ARDALKLAAC LGSSLDLDPL AIVARRSAEA LRGALEEAVR
EGLLLRRGSG YRFLHDRVQQ AAYSLIPAEQ LAEVHLRIGQ LLVKAQRPGE RDESLFDVVG
HLNRGAALLR SQVERDDLAA LNLRAGRKAK AAAAFQSAAA LLAAGLSLLA PDRWEARHEL
TYELTFERAH VAYITGGFDE AERLLEELME RARTRIETAA AVELAVALNV TRGRHARAVE
IGLGWLRACD IALPLCPSDA RVDEETEHVW RDLGDRAIAD LVHLPRMTHP EIESAMGVLN
GVSLPAFFMD ANLHYLIVLR MVQLSLRHGN ADSSSNAYTF FARVIGPRYG RYREGYLFGK
LGHDLAQRSG LLTTKSVVLT MFGQHIVFWT RHYRETTPYT RAGFSAAVES GNLNDACYNC
MWAEIFPLLS GEPLEDVLRA VEERLGFVRR AGYALPHRVL FSIYAMIQAL RGRPARLSAV
DGSELDLLAF EASLEEENPP LVRAIHYNLK AQARFLIGPP GAAFAAVTRG RAEHPYRVES
NVIIAESFYY LALSLAALSS EAHEARPAPR GDLPEELLEC ERQLGAWARS CPENFLHKHA
LVRAEIARLR GQEPQAMRLY EQAISSALEN GFVQHEAIAC ELAAGFYRAC GLSTAADAYL
QEARAGYFRW GAHAKVEQLD QRYPYLAPRR PIAPTVTFAV RAEQFDVPSV VTACQSISGE
LKLPRLLEML LRIVVEHAGA GEGVVLLVRE DRLSIAAAIS TSRSTSGGAA RLLDAGEAAA
TALPQSVLNY VRRSHERVLL DDAAGRHPFS EDGYFKQRGA GSALCLPIVR QARLLGLLYL
ENRLITGAFT PGRLTVLELL ASQSAISLEN ALLYTDIEQE NAERRRAERE LQANQKTLQA
IVDNSAASIY LKDRDGRYLL ANCHADSAVG LSRHRLVGKT DAEVFPASTA ELLRDNDRRV
LDAGEPLQCE EEILLDDGPH TFLSVKFPLG ERVMPGVLCG ISTDITQRRR AELAERFLAE
ASRKLMALGY GATLDSVAQL AVPELADQCV IDVDLARGAP GHTIAKGVPA ELARAVLDAL
QPLSAASLQR PEVGDVRAAP LLEPLGVHSF LRAPLLARDR CFGVMTLLAT APRRRYGPAD
LWLAQELASR AALALDNSRL FAEAQVAIER RNEFLLVASH ELKTPLTSLK MQAHLLARLL
PRFQRAEVAP ERIDAAIQVL NRQIARLAHL INELLDVTRL NAGRLTLARA PLDLAALARE
VVERMHQQLD DACCRTQIEL EAPVIGDWDA SRMEQVLINL LSNAIKYGAG APIHVVVRGG
GDRALLVVRD HGIGITETDQ ARIFERFERA VSARSFGGLG LGLYIVRWIV TSHGGTIRVE
SEPGAGAAFI VELPLRPAEA ETAAEGAGQG EGALLPSA
//
