ID A9IWC7_BART1 Unreviewed; 202 AA.
AC A9IWC7;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN Name=pncA {ECO:0000313|EMBL:CAK01944.1};
GN OrderedLocusNames=BT_1607 {ECO:0000313|EMBL:CAK01944.1};
OS Bartonella tribocorum (strain CIP 105476 / IBS 506).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=382640 {ECO:0000313|EMBL:CAK01944.1, ECO:0000313|Proteomes:UP000001592};
RN [1] {ECO:0000313|EMBL:CAK01944.1, ECO:0000313|Proteomes:UP000001592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 105476 / IBS 506 {ECO:0000313|Proteomes:UP000001592};
RX PubMed=18037886; DOI=10.1038/ng.2007.38;
RA Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G.,
RA Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.;
RT "Genomic analysis of Bartonella identifies type IV secretion systems as
RT host adaptability factors.";
RL Nat. Genet. 39:1469-1476(2007).
CC -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
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DR EMBL; AM260525; CAK01944.1; -; Genomic_DNA.
DR RefSeq; WP_012232070.1; NC_010161.1.
DR AlphaFoldDB; A9IWC7; -.
DR KEGG; btr:BT_1607; -.
DR eggNOG; COG1335; Bacteria.
DR HOGENOM; CLU_068979_13_1_5; -.
DR Proteomes; UP000001592; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008936; F:nicotinamidase activity; IEA:UniProtKB-EC.
DR GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd01011; nicotinamidase; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR PANTHER; PTHR11080:SF2; LD05707P; 1.
DR PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CAK01944.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642}.
FT DOMAIN 5..198
FT /note="Isochorismatase-like"
FT /evidence="ECO:0000259|Pfam:PF00857"
SQ SEQUENCE 202 AA; 22407 MW; EF5A21FFE074DB6D CRC64;
MKKEALLVID VQNDFLPGGA LAVPQGDTIL PAVNNLIHHF DHVILTQDWH PKNHCSFAST
YPEKKPYDTI DLDYGAQILW PDHCIQGTQG AEFYPSLRVE KAQLILRKGY NQNMDSYSAF
LENDQKTPTG LQVYLKEHGF TKLVMCGLAT DFCVGFSALH AIQCGFKVSV SLNACAGIDV
NESLNTMLKT MNEAGIELLM NS
//
