ID A9J667_9CALI Unreviewed; 97 AA.
AC A9J667;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 08-NOV-2023, entry version 48.
DE SubName: Full=RNA-dependent RNA polymerase {ECO:0000313|EMBL:CAP17594.1};
DE Flags: Fragment;
GN Name=RNApol {ECO:0000313|EMBL:CAP17594.1};
OS Norovirus Hu/GII-4/Tarrasa/772/02/Sp.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
OX NCBI_TaxID=481793 {ECO:0000313|EMBL:CAP17594.1};
RN [1] {ECO:0000313|EMBL:CAP17594.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hu/GII-4/Tarrasa/772/02/Sp {ECO:0000313|EMBL:CAP17594.1};
RX PubMed=18461627; DOI=10.1002/jmv.21182;
RA Buesa J., Montava R., Abu-Mallouh R., Fos M., Ribes J.M., Bartolome R.,
RA Vanaclocha H., Torner N., Dominguez A.;
RT "Sequential evolution of genotype GII.4 norovirus variants causing
RT gastroenteritis outbreaks from 2001 to 2006 in Eastern Spain.";
RL J. Med. Virol. 80:1288-1295(2008).
CC -!- FUNCTION: Viral genome-linked protein is covalently linked to the 5'-
CC end of the positive-strand, negative-strand genomic RNAs and subgenomic
CC RNA. Acts as a genome-linked replication primer. May recruit ribosome
CC to viral RNA thereby promoting viral proteins translation.
CC {ECO:0000256|ARBA:ARBA00025359}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM904706; CAP17594.1; -; Genomic_RNA.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:CAP17594.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 1..97
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAP17594.1"
FT NON_TER 97
FT /evidence="ECO:0000313|EMBL:CAP17594.1"
SQ SEQUENCE 97 AA; 10434 MW; 9BFB9A578178A9A9 CRC64;
TQQRAVLAAA LEIMVKFSSE PHLAQVVAED LLSPSVVDVG DFTISINEGL PSGVPCTSQW
NSIAHWLLTL CALSEVTNLS PDIIQANSLF SFYGDDE
//
