ID A9JRL9_XENTR Unreviewed; 2316 AA.
AC A9JRL9;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Mll protein {ECO:0000313|EMBL:AAI55711.1};
DE Flags: Fragment;
GN Name=mll {ECO:0000313|EMBL:AAI55711.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI55711.1};
RN [1] {ECO:0000313|EMBL:AAI55711.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI55711.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; BC155710; AAI55711.1; -; mRNA.
DR GO; GO:0035097; C:histone methyltransferase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd05493; Bromo_ALL-1; 1.
DR CDD; cd15693; ePHD_KMT2A; 1.
DR CDD; cd15588; PHD1_KMT2A; 1.
DR CDD; cd15592; PHD3_KMT2A; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 6.10.250.2390; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR041958; KMT2A_ePHD.
DR InterPro; IPR042023; KMT2A_PHD1.
DR InterPro; IPR044133; KMT2A_PHD3.
DR InterPro; IPR016569; MeTrfase_trithorax.
DR InterPro; IPR002857; Znf_CXXC.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45838:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE 2A; 1.
DR PANTHER; PTHR45838; HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF02008; zf-CXXC; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR PIRSF; PIRSF010354; Methyltransferase_trithorax; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00249; PHD; 4.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS51058; ZF_CXXC; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 2: Evidence at transcript level;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00509}.
FT DOMAIN 1086..1134
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 1376..1427
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1424..1493
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1526..1587
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1663..1708
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1829..1937
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 90..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1783..1825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2039..2068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2092..2135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2147..2198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2236..2316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..232
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..254
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..530
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1787..1806
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2047..2068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2109..2128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2152..2198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2316
FT /evidence="ECO:0000313|EMBL:AAI55711.1"
SQ SEQUENCE 2316 AA; 255803 MW; 1E946581C35763CA CRC64;
MAHSCRWRFP ARPGTGRRLG ARHRLSAILI DDVSEYRSNP GASGSAGASS AGTLAPGGPG
NCLGVALGFD AALQVSAAIG NNLRRFRDVS GGSSGEEEQF LGFGSDEEVK GRSPAKSPKD
QTTQRKPRGR PRNSLSRCSD ASSNLCENTT STLNKQETRL LDKVKKPESK TEEKKRGRPP
AHGNVKFKLP QEKRDGTESI KAPCEEKSKR RKPSATFQHA AKIKKLRAGK LSPLKSKFKS
NKLKLGRKGG VSIVRRRGRP PSSERFKTDT HGSFPKQVPT DRSQRGNKDV SPQPSKEDTR
VSVRQSPRRM KPVRIIPSSK RTDTAIAKQL LQKAKKGAQK KMELEAAKLQ GRKGGTQLKN
IRQFIMPVVS TVSSRIIKTP RRFIEDEDYE PPIKIARLES APNGSRFSTA SCGSSEKSSA
ASQQSSQATS DDSRSSSPSV DTSTESQASE ETPVVSEPQG RVAETITSVP TQQQPLESNG
VRTRRLPVCN KNFSSRPAKK IVLRPSFQQK SSVSPPPPLL SPPTPLQPSA SLPDHTPWLM
PAIPMATPFI SASRMHEKRR SILREPTFRW TSLKHSRLES QYFSSAKYAK EGLIRKPIFD
NFRPPPLTPE DVGLATASGF PSHTVVGPGR LFSHIHSSGA RFDVHKRSPL LRAPRFTPSE
AHSRIFESVT LPPSAGRASG TSSMMGISRR SKRRVFNPIR SSEPKSPSHS MRTRSRRVGN
SSLSVLASPP SSSLTDISVS PLATSALNPS FPFSSSSVTP ASVDIAEKIQ KPRKPTSTPA
EHFTSSPSSS PALFPWFPSS VQMEKGKSKN RGSVESSKER EVEKNREKDR EKENSRDSRR
DKRKKSSDSG CKISRERNDE EGIVTATQIK MSVRKKPVTV ESNVDISPAS IHTDQIPAKN
KISKKGRPVS EKTELDTCAK SPTAETQAQL PAQPVSALKH PSTSISSMLA QADKFPVSDK
HVATLLRKAK AQLCKIEKSK FLKQTDQPKA QGQESDSSEA SVRGPRIKHV CRRAAVALGR
KRAVFPDDMP TLSALPWEER EKVLSSMGND DKSSIAGSED ADQPAPPLKP IKQITRNKAQ
QEPPVKKGRR SRRCGQCPGC QVPDDCGICT NCLDKPKFGG RNIKKQCCKM RKCQNLQWMP
SKAYLQKQAK AAKKKERKCK VTEKKELPPV KSPSELIVKP VSAPGTSSPP VQEEPATPSL
PQKKNEPPKK QTEEKSEEQI PAASTSETKQ SPNSRKTTKQ PPSQPSTTIA MTPLTATPST
KKEAPKPIPP ESRKKQPPVL PDNTSTEQNK QKKLAMRLGA LLKSKGKEKD KPQPPSKPEV
SFNLLNTLCN GGITKQKPPS DGVHRIRVDF KHDCEVENVW DMGGISLLTT APVTPRVVCF
LCASSGHVEF VYCQVCCEPF HRFCLEERER PSEDQIENWC CRHCKFCHVC GRQQQATKES
IGRQNTISDM SLKQLLECNK CRNSYHPECL GPNYPTKPTK KKRVWICTKC VRCKSCGSTT
PGKGWDAQWS HDFSLCHDCA KLFAKGNFCP LCNKCYDDDD YESKMMQCGK CDRWVHSKCE
NLTDEMYEIL SNLPESVAYT CINCTERHPA EWRMALTNEL QASLRYVLTA LLNSRTSSHL
LRCRQAAKPP DLNPEPDENM PSRSSAEGPD PPILTQVGKQ DEQPPLDLEG VKRKMDHGKY
KSVLEMSDDI VRIIQAAMNA DGGQPELKKA NSMVKSFFTR QMERVFPWFS VKKSRFWEPN
KVTSNSSMLP NAVLPPSLDH NYAQWQEREN RLAMQPVLMK KIIPAPKPRS PGDPESPQPV
QPSTPPAPTT ELNREESPEL PPPPGLEDNR QCALCLKYGD DNANDAGRLL YIGQDEWTHV
NCALWSAEVF EDDDGSLKNV HMAVIRGKQL RCELCLKLGA TVGCCLTSCT SNYHFMCSRK
KNCVFLEDKK VYCQKHKDLI KGEIVSDNGF EVLRRVFVDF EGITLRRKFL NGLEPDNIHI
MIGSMTIDCL GILSDLSDCE QKLFPIGYQC SRVYWSTTDA RKRCVYTCKI LECRPPPADP
DINSTVQHEE NRTIAHSPQS LHSDVQENQS TDGIKCIETL CLSSPDSVSA ASVTKPWEVG
RPSGCRTHIP RYSPSQRSPG SRPLPSAGSP SPVTHEIVTV GDPLLSSGLR KIGSRRHSSS
SLSPQQHKKI FSPHPQTDIS RFGQPLQGIP VNSLENSGNG DPVCIGASTI SSKSSCSPNT
GQKAIECKLE KAPEARRTGF LETPSKVSTP KTEKVKTASP RVSDPSSEHP SPKVPSQVQE
MTADASKNKA GCLKDSSPAL LNFKTSSNMQ HQKKKK
//
