ID A9JRY6_DANRE Unreviewed; 860 AA.
AC A9JRY6; A0A0R4IWL9; A0A8M1NG15;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=unc5a {ECO:0000313|EMBL:AAI55846.1,
GN ECO:0000313|Ensembl:ENSDARP00000139881,
GN ECO:0000313|RefSeq:NP_001107937.1,
GN ECO:0000313|ZFIN:ZDB-GENE-080219-19};
GN Synonyms=zgc:175190 {ECO:0000313|RefSeq:NP_001107937.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI55846.1};
RN [1] {ECO:0000313|EMBL:AAI55846.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI55846.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001107937.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23806443;
RA Yang B., Peng G., Gao J.;
RT "Expression of unc5 family genes in zebrafish brain during embryonic
RT development.";
RL Gene Expr. Patterns 13:311-318(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000139881, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139881};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000139881}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139881};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001107937.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [6] {ECO:0000313|RefSeq:NP_001107937.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; CABZ01070365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01070373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01080532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC155845; AAI55846.1; -; mRNA.
DR RefSeq; NP_001107937.1; NM_001114465.1.
DR STRING; 7955.ENSDARP00000139881; -.
DR PaxDb; 7955-ENSDARP00000106720; -.
DR Ensembl; ENSDART00000170949.2; ENSDARP00000139881.2; ENSDARG00000099034.2.
DR GeneID; 799734; -.
DR KEGG; dre:799734; -.
DR AGR; ZFIN:ZDB-GENE-080219-19; -.
DR CTD; 90249; -.
DR ZFIN; ZDB-GENE-080219-19; unc5a.
DR OMA; QKSACTT; -.
DR OrthoDB; 2971005at2759; -.
DR Reactome; R-DRE-373752; Netrin-1 signaling.
DR Proteomes; UP000000437; Chromosome 14.
DR Bgee; ENSDARG00000099034; Expressed in retina and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IBA:GO_Central.
DR GO; GO:0033564; P:anterior/posterior axon guidance; IBA:GO_Central.
DR CDD; cd08800; Death_UNC5A; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042155; Death_UNC5A.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF4; NETRIN RECEPTOR UNC5A; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 311..335
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 165..246
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 459..602
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 860 AA; 96247 MW; C70657BEE09291B8 CRC64;
MPLHLSPFVR WRSGVVLTWI CFFFSSGFTF AGGEHAATVT HPLPVAFSDQ LPHFLIEPDD
VYIVKNKPVT LTCRSTPATQ IYFKCNGEWV HQDQHLIDRD VDPATGLPVM QVKIDISRQQ
VEKIFGLEDY WCQCVAWSTT GTQKSQKAFV RIAYLRKNFE EEPLGKEVAL DQELLLRCHP
PEGVPPAEVE WQRNEELIDP KTDPNFFITT DHNLIIKQTR LADTGNYTCV AKNIVARRKS
SSATVIVYVD GGWSEWSKWS PCGADCSMWR SRECTQPTPG TGGKDCQGLD LQSLNCTSEQ
CPQTASGAED VALYVGMVTV ALCLALLLVV LVLVYRRKKE GLDADVADSS ILTTGFQPMG
IKPSKPGVWA PRRAARCKNS HLLTIQPDLT TSTSSYQGSL RSRHEVSSKF SMSNGPLLDP
LPNGSHTLHN GKLSSDADDF MSRLSSQTYL KTLPRENGNT SYGTFNFLGG RLTLPNTGIS
LLIPPEAIPR GKIYEIYLTI QKKEDMRLPL AGCQTLLSPV VSCGPPGVML TRPVILCMDH
CSDACLENWA IRLKKQSYEG TWEDVLLLGE DLLSEPYYCQ LEAETCRVFT EQLGRFALVG
ESLSMAAAKR LKLLLFAPAY CSTLEYNIRV YCTDDTQDLL KEVMQMERQL GGRLIDEPHV
LLFKDSYHNL RLSIHDMPHT HWRSKLLAGY QEIPFYHIWS GSQRTLHCSF TLERQSLSTS
DLSCTLCVWQ VEGEGQSFSL DFNIAKDIRP LDSDFLLLEN CSPALAGPSA FQIPYLIRQK
ICSSLDAPCP NGADWRLLAQ RLKLDRHMSF FASKSSPTSV ILDLWETQHF HSGNLNQLAA
VMAEIGKQEA MIFLVSDGEC
//
