ID   A9JTT6_XENTR            Unreviewed;       778 AA.
AC   A9JTT6;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE   Flags: Fragment;
GN   Name=rnf123 {ECO:0000313|EMBL:AAI55471.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI55471.1};
RN   [1] {ECO:0000313|EMBL:AAI55471.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6 {ECO:0000313|EMBL:AAI55471.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:AAI55471.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC155470; AAI55471.1; -; mRNA.
DR   AlphaFoldDB; A9JTT6; -.
DR   SMR; A9JTT6; -.
DR   HOGENOM; CLU_006687_2_0_1; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd16541; RING-HC_RNF123; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR045129; RNF123/RSPRY1-like.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR   PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          725..763
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          184..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAI55471.1"
SQ   SEQUENCE   778 AA;  87578 MW;  90EAF0CA6DD7755C CRC64;
     LNKFRKFLQE NASNRGNPTV LCPPEYMVCF LHRLISALRS CWDEYKIRNP LACGSDEAYV
     PPQLFYNGKV DYFDLQRLGG LLSHLRKTLK DELAAKANIV IDPSELQAVT MDDLEEEDES
     ANTTAQRSSA ALAIGGALAR PSWLSSPTLG RANRFLSTAA VSLMNPRRPL GALDKVKVRS
     LSVDQRTEDD IEGQHGNDGL LLGRPPEEAD TVITENSLLE ILDGAVMMYN LSVHQQLGKM
     VGVSDDVNEY ALALKDTEEK IKRCPKRRAD IMDELVKSQR VFSEKLNHLS RRLAWINVTI
     YSKDKMQDIY WLLQVCLRSI EHADRTGSLF AFMPEFYLNV AMNSYNALKN YFSPVSSMEE
     LQGYEETLTR LATILAKHFA DPRIVGTDIK DSLMQALASY VCYPHSLRAV ERISEEQQIS
     MMKNLLAPYE QRPWAQTNWI LVRLWRGCGF GYRYTRLPHL LKTKPEDANL PSLQKPCPST
     LLQNHMAELL RGDPELASSF LNSVLNQLNW AFSEFIGMIQ EIQQAAERLE RNFVDSRQLK
     VCATCFDLSV SLLRVLEMTV TLVPDIFLDW SRSSSELLLR RLAQLLNQVL NRVTAERNLF
     DRVVNLRLPG LESVDHYPIL VAVTGILVRL LVDSSSQGIQ RATAVLLADP CFQLRSIQYL
     LGQAEQSVLG AGPPSADKKH FSLQAYTDYI NAEELGKVSN MLAHLSEESK QAAAATQPTS
     EEDLCPICYA HPISAVFKPC SHKSCKACIN QHLMNNKDCF FCKATITGVD DYEKPTAN
//