ID A9L902_PAPAN Unreviewed; 1033 AA.
AC A9L902;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=NLR family, pyrin domain containing 12, isoform 2 (Predicted) {ECO:0000313|EMBL:ABX52165.1};
GN Name=NLRP12 {ECO:0000313|EMBL:ABX52165.1};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|EMBL:ABX52165.1};
RN [1] {ECO:0000313|EMBL:ABX52165.1}
RP NUCLEOTIDE SEQUENCE.
RA Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA Tsipouri V., Young A., Green E.D.;
RT "NISC Comparative Sequencing Initiative.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; DP000506; ABX52165.1; -; Genomic_DNA.
DR RefSeq; NP_001162527.1; NM_001169056.1.
DR AlphaFoldDB; A9L902; -.
DR GeneID; 100137561; -.
DR KEGG; panu:100137561; -.
DR CTD; 91662; -.
DR OrthoDB; 55870at2759; -.
DR CDD; cd00116; LRR_RI; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF11; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 5.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 11.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}.
FT DOMAIN 1..95
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 211..411
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 91..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 117361 MW; D87ADCCCFB622533 CRC64;
MLRTTGRDGL CRLSAYLEEL EAVELKKFKL YLGTATELGE DKIPWGRMEM AGPLEMAHLL
ITHFGTEEAW RLALSTFERM NRKDLWERGQ REDLVRDTPP GGPSSLGNQS TCLLEASPVT
PRKDPQEAYR DYVRRKFRLM EDRNARLGEC VNLSHRYTRL LLVKEHSNPM QAQQQLLDIG
RGHTRTVGHQ ASPIKIETLF EPDEERPEPP RTVVMQGVAG IGKSMLAHKV MLDWADGKLF
QGRFDYLFYI NCREMNQSDT ECSMQDLISS CWPEPSAPLQ ELVRVPERLL FIIDGFDELK
PSFHDPQGPW CLCWAEKRPT ELLLNSLIRK KLLPELSLLV TTRPTALEKL HRLLEHPRHV
EILGFSEAER KEYFYKYFHD TEQAGQVFNY VRDNEPLFTM CFVPLVCWVV CTCLQQQLEG
GGLLRQTSRT TTAVYMLYLL SLMQPKLRTP RLQPPPNQRG LCSLAADGLW NQKILFEEQD
LRKHGLDGAD ISAFLNMNIF QKDINCERYY SFIHLSFQEF FAAMYYILDD GERGAGPDQD
VIRLLTEYGF SERSFLALTI RFLFGLLNEE TRSYLENSLC WKVSPHIKRE LLQWIRSKAQ
SDGSTLQQGS LEFFSCLYEI QEEEFIQQAL SHFQVIVVSN IASKMEHMVC SFCVKNCRSA
QVLHLYGATY SADGEDRARC SAGAHTLLVQ LPERTVLLDA YSEHLAAALC TNPNLVELSL
YRNALGSRGV KLLCQGLRHP SCKLQNLRLK RCRISSSACE DLSAALIANK NLTRMDLSGN
GVGFSGMTLL CEGLRHPQCR LQMIQLRKCQ LESGACQELA SVLSTNPHLV ELDLTGNALE
DLGLRLLCQG LRHPVCRLRT VWLKICHLTA AACEELASTL SVNHSLRELD LSLNELGDPG
VLLLCESLRH PTCKLQTLRL GICRLGSAAC EGLSAVLQVN HHLRELDLSF NDLGDWGLWL
LAEGLQHPTC RLQKLWLDSC GLTAKACKNL YFTLGINQTL TELYLTNNAL GDTGVRLLCK
RLNHPGCKLR VLW
//
