ID A9LSS4_AEDAE Unreviewed; 271 AA.
AC A9LSS4;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Kdr {ECO:0000313|EMBL:AUO28903.1};
DE SubName: Full=Voltage-gated sodium channel domain IIS1-IIS6 {ECO:0000313|EMBL:ABX47009.1};
DE Flags: Fragment;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:ABX47009.1};
RN [1] {ECO:0000313|EMBL:ABX47009.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PMD {ECO:0000313|EMBL:ABX47009.1}, and PMD-R
RC {ECO:0000313|EMBL:ABX47010.1};
RA Yanola J., Somboon P., Walton C., Nachaiwieng W., Prapanthadara L.-a.;
RT "A novel F1552/C1552 point mutation in the Aedes aegypti voltage-gated
RT sodium channel gene associated with permethrin resistance.";
RL Pestic. Biochem. Physiol. 96:127-131(2010).
RN [2] {ECO:0000313|EMBL:AUO28903.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C1 {ECO:0000313|EMBL:AUO28903.1};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EU259808; ABX47009.1; -; mRNA.
DR EMBL; EU259809; ABX47010.1; -; mRNA.
DR EMBL; MF346321; AUO28903.1; -; mRNA.
DR AlphaFoldDB; A9LSS4; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000313|EMBL:ABX47009.1};
KW Ion transport {ECO:0000313|EMBL:ABX47009.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:ABX47009.1}.
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..269
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABX47009.1"
FT NON_TER 271
FT /evidence="ECO:0000313|EMBL:ABX47009.1"
SQ SEQUENCE 271 AA; 31231 MW; 74CF10816A5CAA63 CRC64;
GPTFKDKALE FTMRMIDVFC VWDCCWVWLK FQEWVAFIVF DPFVELFITL CIVVNTLFMA
LDHHDMDPDM ERALKSGNYF FTATFAIEAT MKLIAMSPKY YFQEGWNIFD FIIVALSLLE
LGLEGVQGLS VLRSFRLLRV FKLAKSWPTL NLLISIMGRT MGALGNLTFV LCIIIFIFAV
MGMQLFGKNY IDNVDRFPDK DLPRWNFTDF MHSFMIVFRV LCGEWIESMW DCMLVGDVSC
IPFFLATVVI GNLVVLNLFL ALLLSNFGSS S
//
