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Database: UniProt
Entry: A9M2W6
LinkDB: A9M2W6
Original site: A9M2W6 
ID   PYRC_NEIM0              Reviewed;         344 AA.
AC   A9M2W6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-SEP-2014, entry version 45.
DE   RecName: Full=Dihydroorotase;
DE            Short=DHOase;
DE            EC=3.5.2.3;
GN   Name=pyrC; OrderedLocusNames=NMCC_0639;
OS   Neisseria meningitidis serogroup C (strain 053442).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Neisseria.
OX   NCBI_TaxID=374833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=053442;
RX   PubMed=18031983; DOI=10.1016/j.ygeno.2007.10.004;
RA   Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X.,
RA   Xiong Z., Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y.,
RA   Shao Z., Liang X., Xu J., Jin Q.;
RT   "Characterization of ST-4821 complex, a unique Neisseria meningitidis
RT   clone.";
RL   Genomics 91:78-87(2008).
CC   -!- CATALYTIC ACTIVITY: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-
CC       aspartate.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the DHOase family. Type 1 subfamily.
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DR   EMBL; CP000381; ABX72835.1; -; Genomic_DNA.
DR   RefSeq; YP_001598789.1; NC_010120.1.
DR   ProteinModelPortal; A9M2W6; -.
DR   SMR; A9M2W6; 2-343.
DR   STRING; 374833.NMCC_0639; -.
DR   EnsemblBacteria; ABX72835; ABX72835; NMCC_0639.
DR   GeneID; 5795114; -.
DR   KEGG; nmn:NMCC_0639; -.
DR   PATRIC; 20345687; VBINeiMen117761_0768.
DR   eggNOG; COG0418; -.
DR   HOGENOM; HOG000256259; -.
DR   KO; K01465; -.
DR   OMA; VAFEPLM; -.
DR   OrthoDB; EOG6TFCMH; -.
DR   BioCyc; NMEN374833:GJ7Z-637-MONOMER; -.
DR   UniPathway; UPA00070; UER00117.
DR   GO; GO:0004151; F:dihydroorotase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019856; P:pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00219; PyrC_type1; 1.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR004721; DHOdimr.
DR   InterPro; IPR002195; Dihydroorotase_CS.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   PIRSF; PIRSF001237; DHOdimr; 1.
DR   TIGRFAMs; TIGR00856; pyrC_dimer; 1.
DR   PROSITE; PS00482; DIHYDROOROTASE_1; 1.
DR   PROSITE; PS00483; DIHYDROOROTASE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis;
KW   Zinc.
FT   CHAIN         1    344       Dihydroorotase.
FT                                /FTId=PRO_1000078099.
FT   METAL        13     13       Zinc 1; via tele nitrogen (By
FT                                similarity).
FT   METAL        15     15       Zinc 1; via tele nitrogen (By
FT                                similarity).
FT   METAL        98     98       Zinc 1; via carbamate group (By
FT                                similarity).
FT   METAL        98     98       Zinc 2; via carbamate group (By
FT                                similarity).
FT   METAL       135    135       Zinc 2; via pros nitrogen (By
FT                                similarity).
FT   METAL       173    173       Zinc 2; via tele nitrogen (By
FT                                similarity).
FT   METAL       247    247       Zinc 1 (By similarity).
FT   MOD_RES      98     98       N6-carboxylysine (By similarity).
SQ   SEQUENCE   344 AA;  37000 MW;  F900D414E30BF3C4 CRC64;
     MQTLTIIRPD DMHLHLRDGD ALKAVVPYTA RQMGRAVIMP NLKPPVVSVA DALAYKARIM
     AALPEGSAFE PLMTLYLTDN ATSELVREAK AAGIVAFKLY PAGATTNSDS GVTDLFKLIP
     VLEEMAKQGI LFLVHGEVTD PEIDIFDREA AFIGRVMKPV LAQVPNLKVV FEHITTAEAA
     RLVLEAGDNV AATVTPQHLL LNRNDLLVGG VRPHHFCLPV LKRETHRQAL VAAVTGEKAH
     KFFLGTDSAP HAKSAKENAC GCAGMFSAMT AVELYAEVFE KAGALDKLEA FASKNGARFY
     GIPENAGTIT LVKQSQTVPA SVPYGDGELV PMRAGGEIGW TVQY
//
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