ID A9QP83_9BACT Unreviewed; 870 AA.
AC A9QP83;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 13-SEP-2023, entry version 68.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=MBMO_EB00055B11g040 {ECO:0000313|EMBL:ABX59251.1};
OS uncultured marine bacterium EB000_55B11.
OC Bacteria; environmental samples.
OX NCBI_TaxID=480665 {ECO:0000313|EMBL:ABX59251.1};
RN [1] {ECO:0000313|EMBL:ABX59251.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18028413; DOI=10.1111/j.1462-2920.2007.01471.x;
RA Rich V.I., Konstantinidis K., DeLong E.F.;
RT "Design and testing of 'genome-proxy' microarrays to profile marine
RT microbial communities.";
RL Environ. Microbiol. 10:506-521(2008).
RN [2] {ECO:0000313|EMBL:ADI19932.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20695878; DOI=10.1111/j.1462-2920.2010.02314.x;
RA Rich V.I., Pham V.D., Eppley J., Shi Y., DeLong E.F.;
RT "Time-series analyses of Monterey Bay coastal microbial picoplankton using
RT a 'genome proxy' microarray.";
RL Environ. Microbiol. 13:116-134(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; EU221239; ABX59251.1; -; Genomic_DNA.
DR EMBL; GU474935; ADI19932.1; -; Genomic_DNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 698..714
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 624..631
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 870 AA; 95847 MW; 0EFA90B516918E8B CRC64;
MMAQFLEIKS EYPNALLFYR MGDFYELFFD DAVAAAAALD ISLTKRGKHL GNDIPMCGVP
HHSAENYLLT LIRKGFRVAV CEQLETPAEA KARGSKSVVK RGVVRLVTSG TLTEDSLLSA
RESNYLCAFS ILRKSSAIAW VDVSTGDLHV QNCPQVSYGP MLAQLNPAEV LISDTNYDSF
KDQTSEFGTT LTSLSPASFD STSNTRRLCD FFKVQSLDGF GTFTRAEISA LGAIIDYLEI
TQKGKLPALK LPIKENLEDF VQIDTSTRRN LELTHTLSGS KNGSLLDVID RTVTGPGARL
LEKRLSSPST CLNTISLRLD AIEAYKPNNS LREEIQNVLR QTSDMERAFS RISLDRGGPR
DFIAIRNSLK KGQDLSRSAL DLXAVLIKNA RQNLKGNEEI IHILDXVFDD NSPLLARDGG
FVRSGFNEDL DEIKRLRDDG RKVISSMQTD FLNLTGITSL KIKYNNVLGY FIETPATHAK
KMLSDAFSST FIHRQTTANA IRFTTIELSE IETKILNAGG KALSLELEIF DQTKLKIIEF
SERILNAAKA LAEIDLTIAL ADIAMSENWC RPKLDKSRKF KITAGRHPVV EAALQKSASG
VFIANNCDLS AGQNGDKPIW LLTGPNMAGK STFLRQNAII ALMAQIGSFV PAESAEIGXI
TQLFSRVGAS DDLARGRSTF MVEMVETAAI LNQAGENALV ILDEIGRGTA TYDGLSIAWA
TLENLHNINN CRALFATHYH ELTSLTENLE GLMNATVSVK EWKGDIIFLH EVKKGAADRS
YGVQVAKLAG IPQTVIRRAT EVLEKLENAD QGGKTKAIIN ELPLFNTNPN NMMKPEGSSQ
IEEQIKDIHP DELTPKDALA LIYKLKSFIK
//
