ID GPDA_YERPG Reviewed; 339 AA.
AC A9R691;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 01-MAY-2013, entry version 51.
DE RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+];
DE EC=1.1.1.94;
DE AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
GN Name=gpsA; OrderedLocusNames=YpAngola_A0073;
OS Yersinia pestis bv. Antiqua (strain Angola).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Yersinia.
OX NCBI_TaxID=349746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Angola;
RX PubMed=20061468; DOI=10.1128/JB.01518-09;
RA Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y.,
RA Mou S., Achtman M., Lindler L.E., Ravel J.;
RT "Genome sequence of the deep-rooted Yersinia pestis strain Angola
RT reveals new insights into the evolution and pangenome of the plague
RT bacterium.";
RL J. Bacteriol. 192:1685-1699(2010).
CC -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(P)(+) =
CC glycerone phosphate + NAD(P)H.
CC -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid
CC metabolism.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC dehydrogenase family.
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DR EMBL; CP000901; ABX86514.1; -; Genomic_DNA.
DR RefSeq; YP_001604712.1; NC_010159.1.
DR ProteinModelPortal; A9R691; -.
DR STRING; 349746.YpAngola_A0073; -.
DR EnsemblBacteria; ABX86514; ABX86514; YpAngola_A0073.
DR GeneID; 5798538; -.
DR KEGG; ypg:YpAngola_A0073; -.
DR PATRIC; 18568969; VBIYerPes97331_0320.
DR eggNOG; COG0240; -.
DR HOGENOM; HOG000246854; -.
DR KO; K00057; -.
DR OMA; DVIGCEI; -.
DR ProtClustDB; PRK00094; -.
DR UniPathway; UPA00940; -.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; IEA:HAMAP.
DR GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:HAMAP.
DR GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR GO; GO:0006650; P:glycerophospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:HAMAP.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_00394; NAD_Glyc3P_dehydrog; 1; -.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR013328; DH_multihelical.
DR InterPro; IPR006168; G3P_DH_NAD-dep.
DR InterPro; IPR006109; G3P_DH_NAD-dep_C.
DR InterPro; IPR011128; G3P_DH_NAD-dep_N.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR11728; PTHR11728; 1.
DR Pfam; PF07479; NAD_Gly3P_dh_C; 1.
DR Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR PIRSF; PIRSF000114; Glycerol-3-P_dh; 1.
DR PRINTS; PR00077; GPDHDRGNASE.
DR SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR PROSITE; PS00957; NAD_G3PDH; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism;
KW NAD; Oxidoreductase; Phospholipid biosynthesis;
KW Phospholipid metabolism.
FT CHAIN 1 339 Glycerol-3-phosphate dehydrogenase
FT [NAD(P)+].
FT /FTId=PRO_1000123207.
FT NP_BIND 12 17 NAD (By similarity).
FT REGION 259 260 Substrate binding (By similarity).
FT ACT_SITE 195 195 Proton acceptor (By similarity).
FT BINDING 110 110 NAD; via amide nitrogen (By similarity).
FT BINDING 110 110 Substrate (By similarity).
FT BINDING 143 143 NAD; via amide nitrogen (By similarity).
FT BINDING 259 259 NAD (By similarity).
FT BINDING 285 285 NAD (By similarity).
SQ SEQUENCE 339 AA; 36194 MW; BD559B0B48242F3E CRC64;
MNTNPASMAV IGAGSYGTAL AITLARNGHQ VVLWGHDPKH IQQLQQDRCN RAFLPDAAFP
DTLRLETDLA CALAASRDVL VVVPSHVFGA VLHQLKPHLR KDARIVWATK GLEAETGRLL
QDVAREVLGE AIPLAVISGP TFAKELAAGL PTAIALASTD VQFSEDLQQL LHCGKSFRVY
SNPDFIGVQL GGAVKNVIAI GAGMSDGIGF GANARTALIT RGLAEMTRLG TALGADPSTF
MGMAGLGDLV LTCTDNQSRN RRFGIMLGQG LGVKEAQDNI GQVVEGYRNT KEVLALAQRH
GVEMPITEQI YQVLYCHKNA REAALTLLGR TKKDEKIGI
//
