ID A9ULN8_XENTR Unreviewed; 268 AA.
AC A9ULN8;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=DNA excision repair protein ERCC-1 {ECO:0000313|RefSeq:NP_001107393.1};
DE SubName: Full=Excision repair cross-complementation group 1 {ECO:0000313|Ensembl:ENSXETP00000119376};
DE SubName: Full=LOC100135224 protein {ECO:0000313|EMBL:AAI57332.1};
GN Name=ercc1 {ECO:0000313|Ensembl:ENSXETP00000119376,
GN ECO:0000313|RefSeq:NP_001107393.1,
GN ECO:0000313|Xenbase:XB-GENE-5895462};
GN Synonyms=LOC100135224 {ECO:0000313|EMBL:AAI57332.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI57332.1};
RN [1] {ECO:0000313|RefSeq:NP_001107393.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI57332.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000313|EMBL:AAI71206.1}, and Whole embryo
RC {ECO:0000313|EMBL:AAI57332.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000119376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000119376};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000119376}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001107393.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ERCC1/RAD10/SWI10 family.
CC {ECO:0000256|ARBA:ARBA00008283}.
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DR EMBL; BC157331; AAI57332.1; -; mRNA.
DR EMBL; BC171206; AAI71206.1; -; mRNA.
DR EMBL; BC171208; AAI71208.1; -; mRNA.
DR RefSeq; NP_001107393.1; NM_001113921.1.
DR Ensembl; ENSXETT00000121883; ENSXETP00000119376; ENSXETG00000026094.
DR GeneID; 100135224; -.
DR KEGG; xtr:100135224; -.
DR AGR; Xenbase:XB-GENE-5895462; -.
DR CTD; 2067; -.
DR Xenbase; XB-GENE-5895462; ercc1.
DR eggNOG; KOG2841; Eukaryota.
DR HOGENOM; CLU_041616_3_2_1; -.
DR OrthoDB; 12065at2759; -.
DR TreeFam; TF101231; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000026094; Expressed in egg cell and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProt.
DR GO; GO:0006302; P:double-strand break repair; IEA:UniProt.
DR CDD; cd22325; ERCC1_C-like; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR047260; ERCC1-like_central_dom.
DR InterPro; IPR004579; ERCC1/RAD10/SWI10.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR NCBIfam; TIGR00597; rad10; 1.
DR PANTHER; PTHR12749:SF0; DNA EXCISION REPAIR PROTEIN ERCC-1; 1.
DR PANTHER; PTHR12749; EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF03834; Rad10; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 2: Evidence at transcript level;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 66..179
FT /note="ERCC1-like central"
FT /evidence="ECO:0000259|Pfam:PF03834"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 30530 MW; 17092137B50EB43C CRC64;
MEKKNYNSRE GGPKIFLSKE PVSHPEETKS TVPKHQVSSV GVRENEVCIM EQAANQTTKS
VGVRSSIIVS TRQRGNSLLK YLRNVPWEFG NIIPDYVLGE TCCALFLSLR YHNLNPEYIH
LRLRSLGQSF ALRVLLVQVD VKDPHFSLKE LAKICILSDC TLILSWSPEE AARYLETYKC
YEQKPADVLK ERTEKDLMSR MAECLTTVKY VNKTDSCTLF TTFGTLFDLA NASREDLSLC
PGLGPQKAKR LYDTFHEPFL KTSTMTFQ
//
