ID A9UMJ4_XENTR Unreviewed; 446 AA.
AC A9UMJ4;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=LOC100135371 protein {ECO:0000313|EMBL:AAI57680.1};
GN Name=XB5774338 {ECO:0000313|Xenbase:XB-GENE-5774339};
GN Synonyms=LOC100135371 {ECO:0000313|EMBL:AAI57680.1,
GN ECO:0000313|RefSeq:NP_001107515.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI57680.1};
RN [1] {ECO:0000313|RefSeq:NP_001107515.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI57680.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=PopA {ECO:0000313|EMBL:AAI57680.1};
RC TISSUE=Neurula {ECO:0000313|EMBL:AAI71066.1}, and Whole
RC {ECO:0000313|EMBL:AAI57680.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001107515.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR EMBL; BC157679; AAI57680.1; -; mRNA.
DR EMBL; BC171066; AAI71066.1; -; mRNA.
DR EMBL; BC171068; AAI71068.1; -; mRNA.
DR RefSeq; NP_001107515.1; NM_001114043.1.
DR CAZy; CBM47; Carbohydrate-Binding Module Family 47.
DR GeneID; 100135371; -.
DR KEGG; xtr:100135371; -.
DR AGR; Xenbase:XB-GENE-5774339; -.
DR CTD; 100135371; -.
DR Xenbase; XB-GENE-5774339; XB5774338.
DR eggNOG; ENOG502QQVA; Eukaryota.
DR HOGENOM; CLU_036681_0_0_1; -.
DR OMA; GDNPAWW; -.
DR OrthoDB; 3970515at2759; -.
DR Proteomes; UP000008143; Chromosome 6.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 3.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713:SF12; FUCOLECTIN TACHYLECTIN-4 PENTRAXIN-1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 3.
DR SMART; SM00607; FTP; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 3.
PE 2: Evidence at transcript level;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001107515.1}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..446
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001107515.1"
FT /id="PRO_5033207380"
FT DOMAIN 25..165
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
FT DOMAIN 168..306
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
FT DOMAIN 308..444
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
SQ SEQUENCE 446 AA; 47766 MW; 3697FFA814546C56 CRC64;
MKCIVVLLVC ISIGWVHSCN VLPGAINLAK SGDAKQSSTY APRYSAQAAA DGNRATNLLT
APCASTAYDN PAWWQVDLKK TYSVDTVVIV NRGDCCRERL RGAEIRVGNS PDNNNPVCGI
INDFSNLITT LCCDGKEGRY VSVVIPGRNE YLNLCELEVY GQEVKAVAGN VALLGVATQS
SNYRSEYGAS NANDGNKNAN MMKGSCSLTG SDNPAWWQLD LKKPYSVEKV VIVNRGDCCW
ERLQGAEVRV GSSTNNKNPV CGTVTDTSQG TITLSCNGME GRYVSVVIPR RAETLQLCEV
EVYGVEAAVN VAGSGEATQS STYGPMYNAA TAIDGNTNSN MMAGSCSHTG NDNPAWWQLD
LKKPYRVEKV LIVNRGDCCG ERLLGAEVRV GSSSSRDNPV CGVVTDVSKP TITLSCNGMG
GRYVSVVIPG RPETLQLCEV EVYAKI
//
