ID A9UQ01_MONBE Unreviewed; 786 AA.
AC A9UQ01;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN ORFNames=MONBRDRAFT_5126 {ECO:0000313|EMBL:EDQ92509.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ92509.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ92509.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH991543; EDQ92509.1; -; Genomic_DNA.
DR RefSeq; XP_001742271.1; XM_001742219.1.
DR AlphaFoldDB; A9UQ01; -.
DR STRING; 81824.A9UQ01; -.
DR EnsemblProtists; EDQ92509; EDQ92509; MONBRDRAFT_5126.
DR GeneID; 5887605; -.
DR KEGG; mbr:MONBRDRAFT_5126; -.
DR eggNOG; KOG3733; Eukaryota.
DR InParanoid; A9UQ01; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF7; SD02261P; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 478..610
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 735..780
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 89449 MW; 3BCFEFA59C59DA64 CRC64;
MSLFNAYMQE ERARERHRQM ATDQEDRHRK AQQQRARQQD AQTAVVDDLI RTRRTQARHL
QAFKQHQQLQ QDEHQSALLE QRQSSTARLQ AEREAGARRR LAALDEARGL ARPVFSIHKL
SLHAAPNLAS SHIAWYRGTS VFSSTNTPRT PLSHIDRMTK SPFQKLRQHH RIPYKFTLNV
LVIIFLSAFY IMKNFQYSYY MDSNTAMLRS RLGNSADDWP MSEYGQTLIY TVDNFVNHFR
TSMDNYWSFN ESALSEYEVN QQLKLRVKYS NGTITSDVMT SENNRYGIIG QLNGSKLVEF
LRVVDTLAID YTFENLQKAD HKHATVMDVH HRWHCNALYD LTYDNGCAVY QLRISNTILS
TSQPVLLVIS SIIITLCIPS AALTLRALWR SFGAFKYART NLKRAPVMTS VNGGASRLPA
NEIMWHHLKL SDKLAFFNLW HVTTVLGDIL LIIGGTLNYS KQLGYQTDKH DSLSSSDICH
ALGGFLVWVG MLKFYEWDSE LYMLILSVKA SLSRVSKFVF CVTPVYMAYV LVGVACFYDH
QDLFGDIFKS SRTLFSLLNG DSVLAVFQEL RENSDLGYDV FAQIYIYSFC IIFIVIICNV
FIFIVESGYD AALNAVYGPE EVLSVFIDHQ RLRDILLVAS TRDPNHTYVP DSLLNQLEEP
PSPELHHRLR LRRGSRGEIN RSFRSHSFFR ARSMDRMDQL GRAFGAGASF SGDNTHQTAT
PRASVPVTGT PAEQRAALAQ NVQHLQARLQ SLNSDMANTL QELQAANAQL QTLAAAEAAQ
TPDSEA
//
