ID   A9UYK5_MONBE            Unreviewed;       641 AA.
AC   A9UYK5;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=FYVE-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MONBRDRAFT_25157 {ECO:0000313|EMBL:EDQ89478.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ89478.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ89478.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
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DR   EMBL; CH991550; EDQ89478.1; -; Genomic_DNA.
DR   RefSeq; XP_001745507.1; XM_001745455.1.
DR   AlphaFoldDB; A9UYK5; -.
DR   EnsemblProtists; EDQ89478; EDQ89478; MONBRDRAFT_25157.
DR   GeneID; 5890960; -.
DR   KEGG; mbr:MONBRDRAFT_25157; -.
DR   eggNOG; KOG1729; Eukaryota.
DR   InParanoid; A9UYK5; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46753; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46753:SF2; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   SUPFAM; SSF57997; Tropomyosin; 1.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          10..137
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          480..538
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   REGION          157..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  71497 MW;  A923D72A2086651C CRC64;
     MAEVLLRQLS ASCEELKLTH YNLNAPLTDN LRDIGIFWNL LERVLRDGSR AFRPTAVPGL
     NHQSTPTGRG RALLRYWLTN NRLAEVLQLA CRNEAMVKRH YHTAALLRQP SSRSRVVDTL
     YNLNEVPCMF ENKLSLDRAW PDFAARSFDA TSLASVRRSS PNVTQDLNTT VSSSSTLRRS
     LSGASLASMQ SSQPRDVPRT ASSSQGEGDA SSSHSWGNRS GSAILGHWQA NESPNEETRA
     TRKEMEALRR ALADARKAQS ASETYAAELK RKLAAVREEL EDAQSSVTTP TLRGEVQAEL
     AKEYEDQLKT LEQQLMDVRQ NMSDAEADRS SMSAVQAEFQ QQISSLQHQL ADETQRTSSL
     QQSLAASEQQ LQEAKHSIER LNTQLTEQEH RLKQQHQADL TEYVALLQEA ERRRAEAEEG
     LKSMTNRHQQ DKQRADLAEQ RCHFLDKLVT RATEAKVSLA EKCFFLLDAA ERMLSIWQPD
     KDAPDCNSCH KAFSVTLRRH HCRVCGQIFC HDCSNFYEQL ANKKQPTRAC RLCVSILKRL
     KEIQTETADT SGQSEDSLSR LAMGLRRPSV GPSARFQSSD SLRLLTAPPS PMVTSPPGRR
     RAAPSNGTFS MTSEEDTEGV TGPDASLEAA ESVTNSEAVA D
//