UniProt: A9V4T6

Database: UniProt
Entry: A9V4T6_MONBE

LinkDB:  A9V4T6_MONBE 
Original site:  A9V4T6_MONBE

All links

Ontology (3)   
   GO (3)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (16)   
   InterPro (9)   
   Pfam (5)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (24)   

Download RDF

ID   A9V4T6_MONBE            Unreviewed;      2669 AA.
AC   A9V4T6;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=MIR domain-containing protein {ECO:0000259|PROSITE:PS50919};
GN   ORFNames=MONBRDRAFT_37956 {ECO:0000313|EMBL:EDQ87425.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ87425.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ87425.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009453}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH991559; EDQ87425.1; -; Genomic_DNA.
DR   RefSeq; XP_001747685.1; XM_001747633.1.
DR   STRING; 81824.A9V4T6; -.
DR   EnsemblProtists; EDQ87425; EDQ87425; MONBRDRAFT_37956.
DR   GeneID; 5893030; -.
DR   KEGG; mbr:MONBRDRAFT_37956; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   InParanoid; A9V4T6; -.
DR   OMA; KMERVIF; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.80.10.50; -; 2.
DR   Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR   PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR   SUPFAM; SSF82109; MIR domain; 2.
DR   PROSITE; PS50919; MIR; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        2204..2224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2271..2294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2300..2320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2351..2370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2376..2396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2408..2432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2502..2525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          126..180
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          245..304
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   REGION          949..972
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1545..1571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2627..2661
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        949..969
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2669 AA;  305054 MW;  EB14A7BBC3F178B7 CRC64;
     MDIGADGKHS GPLCYGDIVS LFLTDGPEYT GFLSTLGNID NRVVVRPQSS KRSVKVPRKF
     RDCLFQIWPM HRYMAQQQYE KELAKRSQDK SSKITIMADM VYLKQLQQAA ELEREQNEQE
     SHKILKSPVQ YGNVIQLLHL KSNKFLTVNK RLTGLVEKSA MRVTLEHVGN EGSWLSISPF
     YKHRSINDSV FVGDKVYVKA VGANQLLHAS TMRLADNPGC AEVNVTNCQD SWKIMLYYEY
     DKDAAAYLKG GDVVRLFHVE ENKHLSADRL ARRDDPVSVY LRTVGRTEKA NVASSKSLWE
     VEVVSEELTY GGNGRWDSFY RFKHLSTDEY LMAIDPNVSE DTHESIRSGS RKGRRRLLLA
     TTTKRHDVNT IFELDSTQPM GGDERVTSDA FVRLKHVASG CWVRALDQFL DGIVGGVINT
     KPQLMEVGAS TERDDREAFA VVPVNNSEIR DLDFCSDTVR VLESNARRIR NGSISLVQRT
     QQHRLLEDLL FFLLDLEGRS AEGVDVTQLT GRPNKDRQRL MREQDVLKQL FYTLKCPFTA
     EACQGCVGSM ISDMQDIFEA KYKWVRELCR LCYTLIRFLA MDYRRNQEII AQHFGFMQSQ
     IGYDLLAEDT ITHLLNSNRK LMEKHITHKE VDNFLNLVRS KREPRYIECL SDLCTSNGTA
     IAGTQELICA AVLENPRNAD LFFNTQDKYG VIMVDWLEEG IHKDKALHDF ASPSIPEDEQ
     SLDMYRAQLD LFAQMCMDRQ YKGINKLRSR MDVRLILKAM SNPSLSDSLR ASFCRLMLHL
     HVDSEPQETV TPVNYARLWK DIPLSMDVTT YSYRSDVHQS HSVRFQGTML FVSQYLDALD
     ESGQDAFSHA DRNKLTLEVV TLARYMIFFG FYDFQELVKL VKRLLRILDA TNESTRILDD
     NIDADTQVVL DTKQQIIEIL SFYMDVRLDF RLSRLLVFFR NTLGTTRPDS RMSTGARGSM
     SSTPPMRRRN SGAFGTDVDQ KRFLRMARSI FAQGVHDEQD LEGEGDDEAG YDESLMQDIS
     AAAATGDMDD HFTRAFLRVL LNLTVLDHSD VVSGALKLLF RNFNQRRELI EAFQQVQLLV
     SETDVEVYRN TRKDLDRLRS MVEKSELWVY AMEDGSSAAA AAAQQNFAVI KRVLVNVSEL
     CLVDFRESRL HHQRLLRNLK AHSEIMQLLK MPCDVSDPAI QDIHCEAHKF LQAFCNGNKE
     NQAEMSQHVG YFIDQIRDGA EMADETLISI YANNSDLCRS VSKATLTAFM AAVGVRGMRR
     VSHIRFLKTI LRPDGQVLPH VQTMVIEAMA SVAADFLQFY NDPTAFRQLE ILLRDADEDL
     LTTRRGDPTD ELLCHIELIE LISLCTEGMN SNTERLCQSL VPLDAVVIRH PDTPPQVKVP
     YTFFLIHCYL ETEVEVKELH SSNDMWRLLD NFVEDIERFC SPDYDMGISS FNDYVTECIT
     NAMRLYFRIL TDSEYGALPN TSKATFVRVV QAMCTLAAKT AQVRLMNVNI ITTLNLLVDF
     AHHRGVQLGN LLEAQVKETV ETCKHGPANS ISKWVRRAKK RVEGSDSLAE AKTSSGATKG
     RPTSADGERS MAKQVVDQLE HMIHFLVRSL TPSSRVEESI LVDVLHHPHR LREMDSGLDQ
     EVFLAKLIAH IRCRDSDDPD SVDKDLRLQV LSVLNRMLSP ELYTGDDRTL RLALLTTFFD
     DDALSDPTFH LNPTDTLEVS EAVQDLLDHS GASVLVIELI MTSDHTQTFY EVGSQSLAVD
     VVDWIASGVS HADRTVYSDV ALLACPWCCW QALQLGINLL EDGNENTQAS FYEFFRANDS
     TNFFAKIQDK MAKSKLDLKQ DEDSVKREKS ADDSSCMVAI LRLLQLLCEN HNSQLQNYLR
     VQKDNKTSYN LVLETVKYLD NYGLALTLSD QNVGNIVQAL STLTEYCQGP CPANQETVAS
     HESNGLDIVV KELLLYEFPE LEKGLRARRR MRTRPELLLE VKKQASALLL SVMESRQDEA
     LAHRILFNMD KHQLVNIIYK LYAAMEDDDD AERDITCTSP CACPQCRRDV GHSIYVLAVT
     LAHRNAELAR LLQQRNLIPD KEQEEAEKQP VVENTPMQRA IAYYAQYTDS IEIYRNGRLE
     QIHFPIPAIC NYLSDNSKEK VLLETDVDEQ NSKIPEFFQS VFLLYEEMKW QKRLKSRQRI
     YDVTVLYSLW KSQAFVLGLL LNVLVAGTFP YDTFEMQSSW RVLLLLYSLA FLGWVGTAVC
     WDVWRRRNQK LPVSERIVQL ETLLNKWKRR DEEEDEEEQS HISLDDYNWR ALQLAVVLTS
     FALVFSNVVA PVIYTLGVLQ VINSLIMLVS FLGSHMSTYL ESEARSSTRE EEGDDDVARV
     RVDRMLNDKS LIYHVGYVCV TILGLCWDFL PIDDVAFGTF WFSLLLVDIV FYNPTLRTVI
     ESVTKNGMSI LLTSLFALIF VYMFSILGYM YFQDHFIMDV DDEWGEQDNV QQRERACDTL
     FACIITTLNH GLRNGGGVGD VLRQVGRGES KFGARVVYDM SFFFFMIVIT LNLILGIIID
     TFTNIREDKE KKMERLRNTC FICGLERSEF DAKGQSFEMH IKRDHDLWSY LNFIVLLLTK
     DETEFTGPES YVFEKLNPRD ADLSWFPRLQ ALSLISSDAE NDEQAMLRNL NNKLLENTKT
     MQSLQAQLSS LQKSVAKSRR RHKTDLISG
//

DBGET integrated database retrieval system