ID A9V5W5_MONBE Unreviewed; 2196 AA.
AC A9V5W5;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=MONBRDRAFT_27644 {ECO:0000313|EMBL:EDQ87117.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ87117.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ87117.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH991561; EDQ87117.1; -; Genomic_DNA.
DR RefSeq; XP_001748060.1; XM_001748008.1.
DR STRING; 81824.A9V5W5; -.
DR EnsemblProtists; EDQ87117; EDQ87117; MONBRDRAFT_27644.
DR GeneID; 5893327; -.
DR KEGG; mbr:MONBRDRAFT_27644; -.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A9V5W5; -.
DR OMA; NECQLKC; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 18.
DR Gene3D; 2.10.25.10; Laminin; 34.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR016201; PSI.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12947; EGF_3; 7.
DR Pfam; PF07645; EGF_CA; 18.
DR Pfam; PF12661; hEGF; 2.
DR SMART; SM00181; EGF; 37.
DR SMART; SM00179; EGF_CA; 32.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 11.
DR PROSITE; PS00010; ASX_HYDROXYL; 26.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 20.
DR PROSITE; PS50026; EGF_3; 32.
DR PROSITE; PS01187; EGF_CA; 10.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..2196
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002745152"
FT TRANSMEM 2111..2131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..488
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 558..596
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 598..637
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 643..681
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 683..719
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 721..760
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 761..798
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 807..847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 849..886
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 888..927
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 929..972
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 974..1014
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1015..1055
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1058..1099
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1100..1140
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1141..1178
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1182..1222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1223..1265
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1266..1306
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1307..1347
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1390..1430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1431..1469
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1472..1512
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1513..1553
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1554..1594
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1595..1636
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1637..1677
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1682..1719
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1725..1763
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1766..1806
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1807..1847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1888..1924
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1938..1968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 478..487
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 586..595
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 671..680
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 709..718
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 837..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 917..926
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2196 AA; 230187 MW; 2A58F2EB8DAA1496 CRC64;
MAPRQRTALA GPWVAMAAAL LLAASASANL DLCYKIRWNL ASNDVKESVI KPVTAFPAEH
ALVSRGYCGG KNTGDPIPHN ARWSTRGRYN YWDCDRVTGG QAFYADVFQQ GIEVLAQTCT
DYCASKSCGE CSVDPQCGWC SGANGGCKPV HQAASCSGDF LEQGCCASCA VHTDCGDCIA
DVATGCAWSF NSGTCISGHS SFGICEAAEW YQIAKAGVSS CRVAPGAVLS EEASAPVPTV
YNSPVVDWCS GHGTADWGDS FSCTCDEGWF GDDCSRECPG GAANPCSGHG TCDTRTGTCM
CQCGFGGSLG QCERELDCDC KADQNNGYCF INETANCPVQ CGKVDDNNVC SGTDVDFVSS
TSDLRRVPGS QCSCASDVWG VKCDQACPVD EQGRVCGGQG SCNVETGQCT CGPCFEQAPD
GSCTPKSCPR CHNGGSCECD AEEGMVCRCL GFFSGDKCRK CDCLNGGSCN EISGACDCPT
GFMGDKCEFE CSRESLCHGH GECNAESQSC DCDPGFVGIG DNLCKWECDD SQCNGHGFCS
HLTGGCECAK GYVAPACEHA CDAGVCQNGA TCLRGDQYAA GYKCQCPPGW TGTFCTQDVN
ECASATLNQC EYADLCVNRE GDYKCECPAG FRLKQNSRTH CVNMNDCPNT WKPCGDHGYC
QDLIQDYECV CDPGFEGALC EINIDDCQSD SCNGHGQCVD GINDFTCACD EGFMGATCSE
DVDECEASPC HPDASCHNSF GSYACTCHPG YTGNGFDTCL NIDECEQEGI CPEHSSCVDT
PGSHRCDCHT GYAKSTDAGS EAEVCVDIDD CFTATGADVC VHATGCTDHL NDFTCTCEAG
WTGKTCNINI DDCNPNPCLH DGACTDGIAS YTCNCDNTGF EGSNCQTEID ECAAADRPAC
QHGGVCQDQI NGYSCNCSSG WTGTHCSENV NECGDGTVFS PNPCQNGGRC VDEPGTFHCE
CDGTGFAGDL CQTNVNECAT GTHSCDANAR CEDRNPGYAC FCKDGYAGSG HECADVNECA
SAEANDCHAT HGLCNNTDGG YTCACAPGFS GDGFTCTDVD ECAAAHTNDC DAEASCGNTF
GSYTCTCNAG YQGNGTTCVN VNECAAQTHT CHRHALCSDT IGSYTCACKS GYTGNGRTCN
DVNECLSATT CGSNAACTNL PGTYNCSCNA GYEGNGFEAC SDINECQRYP GTCGAHASCT
NTAGSYTCRC DSGFSMTDAG CEDVDECATD AHACEASAAC VNGVGSYHCS CEDGYELTAS
GLACQDVDEC AEGTDTCAAK ATCENTIGGF ACTCNTGYRG DGHTCAQIDE CAESSPCQAN
ADCYDTDGSY FCQCTEGYEA DGTGQCVDVP ECACGLHDCD ANARCVEAPG SYSCACKAGY
TKNEHDVCVD IDECDTGADN CHEHATCINT AGSFQCACNT NYTGDGVHCE HPLDCDPETK
PCDEHATCGE TASGPRCSCH AGYAGTGFVC TNVDECSTGT HNCAANAECL DTVGSFTCTC
ADGYEGDGLS CTDINECLSD ETCAEHAECT NVPGSFRCQC QDGFEGNGQE QCTDVNECVR
FPDICGRNAA CSNTAGNYSC TCNSGYTPTS EGCVDTDECA TGTHSCTGVA TCANKVGGYS
CGCPAGYQLQ GKYTCVDIDE CSATGSTAAC ANAALCNNTV GGFACSCPAG YRGDAYQSGC
VQIDECAEGA QCDAHEDCVD TDGSYFCQCS AGFERGDGEL AGCVDVPECA RGLDNCADHA
LCTETMGGYA CECADGFEGD GFVCTDVDEC ASQLDDCHEQ AKCTNVPGDY TCSCNNGYRG
DGRICTDIPE CSLGTHACHR DAVCIEAAPG YDCQCQPGYE GNGTFCQDIA ECETVQCPTG
AVCVELPGSY DCEAADGYEE EDDGSFSDID ECDRGTHQCE HYCINTPGSY RCSCQVSFTL
RRDGFTCIPN NETTTTTTTT TTLRTTTTTT TASRSSSSTT TTTSSIKNAG PRTLRLVETV
TFGSAQCVAQ AEHFVAIDTP ELHAIIAREF GALSSTKNIE SSVNYAANDD GDIVLTYVVD
FSESEKEAVE QKAVQVKTLL NEFVQLLDTS SSDCDFFEDV DVKTNSNMQI LSNDDEEDSS
TTENKNDVGS LIPIIAVCAV LLVVVVVVVT ARNLSWGAGD GFTLGKATGL LLADGDFDNP
MHSAKQRGVA FDNPVYDDLD VDETDDEDFE EDFEEF
//
