ID A9V6C0_MONBE Unreviewed; 872 AA.
AC A9V6C0;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=MONBRDRAFT_33599 {ECO:0000313|EMBL:EDQ87041.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ87041.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ87041.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH991562; EDQ87041.1; -; Genomic_DNA.
DR RefSeq; XP_001748280.1; XM_001748228.1.
DR AlphaFoldDB; A9V6C0; -.
DR EnsemblProtists; EDQ87041; EDQ87041; MONBRDRAFT_33599.
DR GeneID; 5893519; -.
DR KEGG; mbr:MONBRDRAFT_33599; -.
DR eggNOG; KOG2533; Eukaryota.
DR InParanoid; A9V6C0; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; IBA:GO_Central.
DR GO; GO:0015760; P:glucose-6-phosphate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR43826; GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4; 1.
DR PANTHER; PTHR43826:SF3; GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..872
FT /note="Major facilitator superfamily (MFS) profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002742858"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 811..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 461..868
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 872 AA; 96242 MW; E8EFC2EDD5C9D8C2 CRC64;
MAQCGLRLGA GLSMTLVWLA LLVPHPAHAY IDDGIFRPDL HDTFQGRFTG LTGTRFFGFQ
EGGQLHLWLN CSASPGHVYL AGLTQKQYGD LRERPSVTCA DIDRMAYAVY LPNSTHPTLP
NTYEVADHFG GPGRHSYYNF MLLECPPGLG SDATPVTCEY LLETINPGGE QLSRDEIPLP
EVYRVFAFLW AAIIVLAIVN TAIYFRFSNA MHKLIFLPVI IFLVVFVLEY HIWTYRSSHG
TDPVAMVNAK TILQFLAEAI FFLVVLCLST GWYIIHESIE RQSRNYIWTL PLSSFGLALL
RHFVHPYFLI LIVLVTVIMV VFVIRASGAN LIYLQHRRID LIGMMNQDLA VHPRLLLPLN
LKLRMLSRVR ALFVAYCILW VIISISASFL SEHTWIAEIM VSALGFLFYA CLLFIMRLWD
FSPFFATENL ASKEVNVELF VDKQQNPLGV LVQVDDGRWQ PAHAAALVMF TTYTGCYFLR
KTLTAAALDL LQEQRATEAD LGLLTSFFSL GYGLSKIPGG IVADLMAPGQ MLQAVLLISA
ALNITFALVG MLSTWMGILL WTANGFVLGF GWSPIGALIH AWFPDPEGRA TWWALISTSQ
NVGAGLAPIA IMNTMHLSVL DGGLLAPWQR AFVWPALLMA ALVPFVGTLL TVPSKEKRVE
TSSKTAPQRD WATWFRELRH LPSLLVLLVV ANMLIYLTKD ILSNWSLLML VHDKGMERSA
AGLTLSYFEA GGIVGSMVAG LASDQLFEGR RGPVCCLYGL GFAAVVLWVQ TTTATWALQA
GYALAGAFLF GPQTLMGLFA MEISPRAQAA LAGSLVSVFS QFGAGLAGYP ITVLQQVFGR
EVALSICVVG GLAWAGVMLP TWGVRPRATR HD
//
