ID A9V8G1_MONBE Unreviewed; 2877 AA.
AC A9V8G1;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MONBRDRAFT_33917 {ECO:0000313|EMBL:EDQ86076.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ86076.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ86076.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991568; EDQ86076.1; -; Genomic_DNA.
DR RefSeq; XP_001749001.1; XM_001748949.1.
DR EnsemblProtists; EDQ86076; EDQ86076; MONBRDRAFT_33917.
DR GeneID; 5894342; -.
DR KEGG; mbr:MONBRDRAFT_33917; -.
DR eggNOG; ENOG502RZNF; Eukaryota.
DR InParanoid; A9V8G1; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006605; P:protein targeting; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000185; SecA.
DR InterPro; IPR014018; SecA_motor_DEAD.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR30612:SF0; CHLOROPLAST PROTEIN-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR30612; SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51196; SECA_MOTOR_DEAD; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 1968..2555
FT /note="SecA family profile"
FT /evidence="ECO:0000259|PROSITE:PS51196"
FT DOMAIN 2620..2818
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 84..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 176..203
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 132..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2877 AA; 315893 MW; 8FF8B500E6BD6A08 CRC64;
MASFFNLGLW LSSNDSLAPS DPCLPHPPYG SPFPAFCSTC STDLNYTTTT FLFASGPPNR
ISSFTSSPAT VIMSFWSALN KLETSDLPPP PDETTEAAET DEGWDAVTIV SAVSGEEPTL
EVSAVSKIKE KAQARSTNEE ERRPPGEHPP PTVPPVPRAV SRAASKVEET VKTARQVDAS
ELAREAQKRI ELLEANLVEY NLVGSDANTG VIFLAPTSSG KTTTLLWLEG HPIEERAVPG
KEHLRHLNVA CSAPDEVQGL VGDGISARTI TPRYLARDRI VYVDPAGFND TRSVILAMIN
SMGLRHLLDK MPRKRIVLLV NFRGLSRLDA VSSMLQSLQR LCPDFEALAP GILFLYSRLD
GNTSKEVIVE LLNGYKARQG IREVPYYTKT LDLMIHQLER HEDTVLLYPH LDAPDGVRNI
IARGIRDCLP FHHMGSPLED GEIAMIQQAI GKELGSLHTY LSSEQPSVYR QGIKHLTTIR
TLAQLINDEA ISEMYHQALD LLGKVIQTHA VSFARALKSG QFEVAARHDK TLQALEGYNQ
ELQQTTAISR NLWSRVQQAC DLVDSAQAFE SLADLQRALR AAAAAVGMRL AKDVSDANEQ
EAFAECALPA VATLCQFDQH LASSCSGRLL WNPIAESLLN EAVQASAAIT AVVQALNSAI
TVPSSRNDLS VDMWQALRSA LGLHQRAQAY SGYVLLDQLR TCYDQDKTLL LEAASQLCAT
ITTIHKLMAE YHAEDLMLER LASLMALLRH VETVAGPECV APGSRHADMQ SAFARVVRDR
LKKPIAHAVT DEQPALAASA LGQLLALLEP FGADEVVQDT QRDALLLLNR LANQQRHCQE
TLRTILAHEG SARDFEALVK AIKALTACQV LDKIIEDARW LPADAGSPDA QAQDQGQEQG
ALSAKVTWQT SAPLIKRTIQ ELHDFLGSLC KDLASALNTR ATPGDRVLTS LQAFHLVQSL
LDDEIVQTLV AQVAATITQA CDHLACSSVE SMSGHTRDGH LKWLTQTAEF VGDLDATYPL
LRSPEWASVQ ASLKDQNERM LADTKAWGDQ LVATVRDTVS EDRLGETASE LDALHELGHA
QDLQVQGIAA PLYEQALEVV RRRLKELYEE FNLSISATDL GVSVKAKKVL IDAIVLHPHL
PEANLITKSI EEKDQAMMNA LREQFDTDLL ANNFHAIHDV LTGLLQTQDA PEWRAAYRGL
KRTAILKMQP ELNQRVEEMQ RAARGIRATH ASTQIGDLLQ RLDQQDAWFV KARVLDAALP
ELRLAEAEKQ FSIIVKNIYH RLCSRLWAAM KKYHFNTAET LYGHLQAWQC VHRADLDSSD
FLNDTSMADT SVAGEAPMSD SASEAPSDVF GAPSKLTAIE RYAAELDTQV TNHVTSLLKE
RRGVELARVL RSLKSVYDGV SEQGLFTTDL VGLVDQVFHQ VHREAQAELS GMQRTLYRQG
GPAAAREQLA AFDELFRPLE TQRLPPFEND ESQICQLHRA VLTEVRDTEE YFTLPALSPE
VADEILAMLA QGRAGNMGRV LDSVKALCKR AVADLQGNCY ANELGLGLTD IVVDRFLGLA
KLGTELKRPD IALASQHVNA MLGSSVTEGF RAVNKWLRSD LQTVHNMLKA FNVDQAREAL
SGLTQSVNRL SATGLPAESL DFLKMLQDTL ESFTVNVKYG TDPVDRLDLA GFIADSFSAE
TLAARIDQLA MVTSAQHSSK SAPVFGSQDV FNPGQALNKV LVHWQGLLRQ ATTVVEECIA
GCQDVSILAA HYAAVAKLAQ RQPAELNDDV AKTLHHLNDR LAAFARSAGA RVQARVEGKH
WHELNENLSF TYQVERALAT LAQAQLPALT TPLADSQEQA LLSRVQAEDY VGNDTLDELA
RCLGRLQELS SNCLAERVKT EVKSRIKARL DGLKGQGSTV DLDLADCLSD VGEYGEEVKQ
SYNQFAEALV RQRKAATKTM TIDKALADMQ AGPHAISAAH ADRLRAAYDS YRREFETHIA
KSTSAIPALV DAVRQKCDKV AHRPNALLTE LPVILAVLAA IWSLGSRKAM AKASQADRGI
YKELHTIQVL ALFELLGLCD AKVGLRRVAS WVKSFVPFGA HDKLSGAFVQ IQTGGGKSIL
LGFASTLYAL LGFEVSCACF SNILSSRDYN DFKDFFDVVQ VAGLVKYGPL SELARAELNV
NGDIRQALQT LVIDGRLSDP TVRPGALPKV LLVDEVDTLL SNVFLTEPYT PGTLVHDDSF
LELLRAVWQD QSLTLAQIQA LPSAQKLLQT YAHTEKLVLA ALENVALARA AFERREHPYE
VQEGLIAYKR EGLDEPSSDI SYGYETQFAY LAEEARGAVM PEVCRQHVGL FCSGGRFSFV
KLIQKFDLIS GVTGTIPDDL ALLRTKFGVG RCSYMPSMYG KINFQRDPVQ LTSNKAQQHQ
AIAGETFERA QGRAVIVFFQ TTADLEAFRA SPEFTAKLGG RPINIITVGS PDIPHRIKQA
TRKDMVTLAT APFGRGSDFT VLNRDIEKNG GIHVIQAFLS VEVTEQIQIE GRTARESNSG
SYRLVLCLED VQALLGEHFP SDIHEGAFAE LPPTLDAARR TLHAEMLAQS FEALAACEAA
HDTSLKLVRE LFSGKKGDPQ NALRYVHEYS AQAEYAEAVD VVVVVDISGS MGPHVPQAQA
FVRTIAQEGF HLDQASSRNR LGILTFDVQA QAMGGEDFLS DDWTTVQQRA AAIATKGYQT
FYLPPLKLLE EKLCQAKAAD PTRYASTRRI VLFQTDGANM DTEKSSAIRA TAERIVDELD
TTLMAVLTGP DVPPDSVAYF VGRAGQFKTM DRSDSDFLAQ LIITVDTYDA LVQRASNIAN
CATSMLQHAW KHGFDANTVC VCVCVCRPLM ARERREALLC RQGLSRKIQT VYIQMFS
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