ID A9VDJ4_MONBE Unreviewed; 3865 AA.
AC A9VDJ4;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=MONBRDRAFT_39292 {ECO:0000313|EMBL:EDQ84379.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ84379.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ84379.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991588; EDQ84379.1; -; Genomic_DNA.
DR RefSeq; XP_001750780.1; XM_001750728.1.
DR STRING; 81824.A9VDJ4; -.
DR EnsemblProtists; EDQ84379; EDQ84379; MONBRDRAFT_39292.
DR GeneID; 5896054; -.
DR KEGG; mbr:MONBRDRAFT_39292; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; A9VDJ4; -.
DR OMA; FFQSCAK; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0036156; C:inner dynein arm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT DOMAIN 2081..2116
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 510..545
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2655..2720
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3865 AA; 437370 MW; 4B9BAE5E7B74D7B6 CRC64;
MGDARNDAVR YYYYMMNGID TTQVVGLDEE WFAHITDLID TQLQTRCAPS VEALHDEVSD
AYLAAIKKSI VDFVLRDPKL DQAGAVAAQW QAYAQNPELA DEQRNWASSI QEARQALEEN
LFLTSPGLRL LLPAYELEHR HQTLLKPEEI CRKKQAYDAV AFGKAIGLQV DRCRHAIQKE
WVRSLAGLLD GLKAQGRLPQ AKSPRYWEAV ATVMSAQLRE LLTVSLNMFL DMIFPPTGVG
SFRGFALQLE VQGDKLGFAV GVEGIETVVL QLLEKMRSSI CEIVRVEYFL AEDRPTGRET
FLTPCFGPEE LASYQQRVEA AFAPQREAPS QWLKLYNEYL FLIDGRADKE MDDFLASQPS
FQLCTDKVYR LLDLARQIEF DMADSARVGL FVIHAAAAKA DLNRKAKALA DRVLTAIADE
VEVSNKDLCK SYAEIAERAA TAPTTTEHLM QLKEFMEQAE NTFARSSPFA IAESCLARHC
TDMSPCNDHS SDLTLNAETF RWVAKLPPLV ESHKQLVRSA RERNENALRE RRDKLNADLE
GFAEELAKFS EYGDSQELQR YLDEASDLNT RLTAAADTIE GINAEEEAFD WEITQYPLKA
KTSNTLAPFL SLYSTAVEYY KQVDEWLNGD FDKIDPEKVE NDVSASWRNL YKIEKGFASE
DAPRGLAAQV KEQVDEFKEN LPMIQAICNP GLRERHWTQL SDIVGYELMP DEETTLSQML
DLDMDSYLDQ FEAISEAASK EFSLEKALSR MKEEWHDMEF HMLSYRDTGT SILSSVDEIQ
MLLDDQIVKT QTMLGSPFVK PFEVEMKEWN DTLVLLQDII DAWLKVQATW LYLEPIFSSP
DIMAQMPEEG RKFNVVDKTW RDTMKEAVQD KHVLMVVRVD KMLEKLNKAN VLLEEILKGL
NRYLEQKRLY FSRFFFLSND EMLEILSETK DPTRVQPHLK KCFEGIAKLS FTEDLDITHM
VSSESELVQL DTVISTSEAR GQVEKWLLQL EEIMRSSIRK IMVEGLECYA GTKRTEWIQS
WPGQIVLAVT QKFWTANVHE AIRGGKQAME TYLQQCTDDI NDVVELVRGK LSKNIRKTLS
ALVVLDVHSR DVLAKLVDDG VSRDDEFNWL AQLRYYFEEG QVITRMINST LAYGYEYLGN
SARLVVTPLT DRCYRTLFGA LELHLGGAPE GPAGTGKTET VKDLAKAVAV QCVVFNCSDG
LDYKALGKFF KGLASSGAWS CFDEFNRIDL EVLSVVAQQI LTIQRGVNAG KDKIMFEGTE
IRLVPTSSVF ITMNPGYAGR SELPDNLKAL FRTVAMMVPD YALIAEIVLY SVGFRSARSL
SVKIVATYRL CSEQLSSQYH YDYGMRAVKS VLTAAGNLKL KYPEESEDIL MLRSITDVNL
PKFLSHDLPL FRGIISDLFP GIKLPEPDYD VLLKAIRENC ARMNLQATDN FVEKILQVYE
MMLVRHGFMI VGEGYGGKTC AYRVLAAALK DISEQGLMEE NKVEITVINP KSITMGQLYG
SFDPVSHEWS DGILAVSYRD FAVSQTPDRK WLIFDGPVDA IWIENMNTVL DDNKKLCLMS
GEIIALADTT NLIFEPMDLE VASPATVSRC GMIYMEPHML GWQPVLESWL NTLPATLTSV
HHELIREYFT RMVPPTLEFI NRPDYRHLSY AGDINLVRSC MEMYDSLMDE FRDEKTFASL
SAQQVENWLE GCFIFSFVWS LGGSTNTEGR QKFNELLRRL MTTGLDQSTM TDWGILTPAG
PPRRPIGVPM PEEMTCFNYL FKKEGPGVWV PWRDLVNNDP FPKDTTFHSI IVPTIDTVRY
TYLLDLLVKH QRYPVFVGPT GTGKSVYVNQ FLAKDLPKET YKPLVVNFSA QTTAQQTQEI
IMGKLDKRRK GLYGPPMGQK VVVFVDDLNM PAKEDYGAQP PIELLRQWMD HWNWYDLKDC
SNLGLADIQL ICAMGPPGGG RNTVTQRFMR HLHCITINEF DDDTNELIFN RIMQWHLDAR
GFDPSFKAVS QSLVRATSAV YKAAFSNLLP TPAKSHYLFN LRDFARVIGG VMMSGPAALP
DHNDMLRLWV HEVYRVFYDR LVFDEDREWF YEFIRTTCQS SLQVPFDELF ASWDADGDGR
VTDDDLRSLM FCDFANPKAD SKEYACVESV AGLQSVCETF LEEYNNVSKK RMDLVLFRFA
IEHVVRIARV VRQPRSHALL VGVGGSGRQS LTRLAAYVND FELVQIELSK AYSKEDWHED
LKRIMRKAGE GGEHVVFLFT DMQIKEPSYL EDISNILNSG EVPNIFPLDE RTEIVEKMRQ
VDKTRPKHLK TDGTPLALFN MFVGRVRDYL HIVLAMSPIG DAFRNNLRQF PSLVNCCTIN
WFQAWPADAL QIVAQRFLEE VEMTDDVRSS CVQLCEEFHE STRALSDRFL ARLRRHNYVT
PTSYLELINT FKTLLDQRRQ AVSKQKRRYE VGLEKLMSAA SQVDGMKDEL VALQPELAKA
QKETDAAMVE IEASSKDVAE QEQVVAADEA VANEQAQAAK AIKDECDADL AEAIPILNKA
LAALNTLTSS DITVVKSMKS PPSGVKLVME AVCILKGVSP EKIPDPSGSG KKIMDYWGPS
KKLLGDMKFL QTLQEFDKDN IPAKLIQKIR DEYIPNEEFV PEKVAKASSA AEGLCSWVRA
MEAYDRVAKV VAPKKEKLKE AEGELAQAMA LLKEKQENLR GIQQQLQDLK DRFKELNDKK
ESLEKQVDLC AKKLDRAETL MGSLGDEKDR WQATAAALGE TYTNLTGDVL VSSGLVAYLG
AFTSEFRHTQ CEEWLKRCKE LKIPSSTTFS LSSTLGDPVK IRDWNIAGLP TDSFSVDNGI
IVSHARRWPL MIDPQGQANK WVKNMEKDNK LSIIKLTDAD FVRTLENAIQ FGTPVLLENV
GEELDSILEP ILLKQTFKQG GAICIRLGDA TIEYSKDFRF YITTKLPNPH YLPETSVKVT
VLNFMITPAG LQDQLLGIVV AEERPELEEE KNALILQSAA NKRQLKEIED KILEVLSSSE
GNILEDETAI KVLSSSKVLA NEISEKQQVA EETEAKIDAA RSGYTPIAKH SSTLFFTIAQ
MAGIDPMYQY SLPWFTKLFL NSIEQSEAAE DLGKRLSNLE AHVTYSVYRN VCRSLFEKDK
LLFSLLLCTN IMKAAGKIEA EEWVFFLTGG VGLDNPHTNP ASWLPTKAWD EICRLDDVHR
FSGIRESFVQ NVDAWRAVYD SPTPQTEAYP ALAAEFDSFQ RLTFLRSLRP DKVTPAVQGF
VEEHMGRKFI EPPPFDLAGA FADSHSCAPL IFVLSPGGDP MSALLKFADD QGFGNSMQTL
SLGQGQGPIA MKMIEKGIQD GTWVVLQNCH LAVSWMSTLE RICEELKPDT THPNFRLWLT
SYPSPAFPVT VLQNGVKMTN EPPKGLRNNI IRSYLLDPIS DMEFFTGCKQ EKPFRRLLYG
LCFFHALVQE RRGFGALGWN IPYEFNDTDF QISIKQINMF LNQYEHVDYE AIRYLIGQCN
YGGRVTDDWD RRCLVSILNN VLNAEMVQND YSFSASGLYM APPHGEYEHY IEFAKALPLI
PEPEVFGMHS NADITKDQKA TNDLLDSILL TQAASGGEGS TGGKSDDERL SEIATDILSK
LPRAFDEAAA LRKYPTTYEE SMNTVLVQEM GRFNRLTEVV RSSLINIQKA VKGLVVMSAE
LEQVAHAMLN GKIPSLWMKK SYPSLKPLGS YVNDLLTRLQ FLQDWYKDGA PNVFWISGFY
FTQAFLTGVQ QNYARKYKIP IDLLSFDFGV MEDRVYEQPP EDGAYVNGLF LDGARWDAER
MVLGEQEAKV LANRMPVIQL IPAKKDEISQ AQVYNCPVYK TSDRRGVLST TGHSSNYVIA
IKLPSDKPED HWIQRGVALL TQLDD
//
