ID A9VE78_MONBE Unreviewed; 847 AA.
AC A9VE78;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
DE Flags: Fragment;
GN ORFNames=MONBRDRAFT_13079 {ECO:0000313|EMBL:EDQ84171.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ84171.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ84171.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; CH991596; EDQ84171.1; -; Genomic_DNA.
DR RefSeq; XP_001751025.1; XM_001750973.1.
DR AlphaFoldDB; A9VE78; -.
DR EnsemblProtists; EDQ84171; EDQ84171; MONBRDRAFT_13079.
DR GeneID; 5896281; -.
DR KEGG; mbr:MONBRDRAFT_13079; -.
DR InParanoid; A9VE78; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR Gene3D; 2.60.120.40; -; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR24019; ADIPOLIN; 1.
DR PANTHER; PTHR24019:SF5; C1Q DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT DOMAIN 373..412
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 373..412
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 417..461
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 417..461
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 467..510
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 467..510
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 391..404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 394..412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 440..453
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 443..461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 489..502
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 492..510
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT NON_TER 847
FT /evidence="ECO:0000313|EMBL:EDQ84171.1"
SQ SEQUENCE 847 AA; 90694 MW; 8BDC41528B7EFEDF CRC64;
MATESGGEDS WTQVRGAKRP SAESPPSNTT TSPSQTHRSA KHTKHGSARH DRNHVFPDPM
TTPLRPRARH SAPTARASSH VPSTSPAAGA SQSFENHFLN NTTRFLTTQN WSSHAVEPDK
ASLFVKERFM RKKRGGCRVR AAATVSALEA ASDGPAALSV VVLLSVTVLC RTAELVAYDG
NLALVLEDPN VNHVLIAQAN DNEAQMFADP NNRLLTKSEV EALLSEMENR FTAVISNLEA
RLQQQLDIKP NRTETVSPAE LDAAVRTDDD IRTVVHAMVS NAPAANSLRA ALDAKVDVAN
QYTDERARTL INTIVNDPDG DDSSLRTALD SLDARVTAAE TNLNTDCGAA CAAGTYESTP
CDPASGSARV CDTCADNTFS YGGSVPGCTT CEACANEHFE VYPCTVSSDR VCAPCESCVP
GSTFEMTDCT ATTDRVCLAC EACPAGTYIA QDCTLSTDRV CVECSTICPE GQWLASSCTG
LTSGACQACS TCSEGYYQVN DCTATSDTLC LRCTDCGEDE VSTPCSATQN AVCMPAGWGF
SSDLNNTLAQ VDNANAYTMI TGFATDTSQW HTSFLRAGTA FNGSTAVVAD TGYYLVSFNV
RFDGLSEEWV HCFMSFNGQI SVERNGLTTV RGTNSNDEWS FTASGTVHLE AGDTFDVRFK
TSTDANYAIH DDTGLSAYRI KPTEGIFAVL PTYATVSESG WYPINGWTTT ATDSATNFLF
GGALKNSAYV VKESGVFLLS ATVRRNNAGV TRTSSPEYYT RLVIAVNNDA TYNSPLHVIQ
GAPFPTDYLS SSVAGLAYLE AGDHVQPYGS AYATYNFQYT PQSHFSAVRL DTSYAFSAFQ
LDSQTIS
//
