ID A9Y4U5_9SAUR Unreviewed; 223 AA.
AC A9Y4U5;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ABU45169.1};
OS Sceloporus variabilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Phrynosomatidae; Phrynosomatinae; Sceloporus.
OX NCBI_TaxID=43638 {ECO:0000313|EMBL:ABU45169.1};
RN [1] {ECO:0000313|EMBL:ABU45169.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17944851; DOI=10.1111/j.1365-294X.2007.03556.x;
RA Leache A.D., Mulcahy D.G.;
RT "Phylogeny, divergence times and species limits of spiny lizards
RT (Sceloporus magister species group) in western North American deserts and
RT Baja California.";
RL Mol. Ecol. 16:5216-5233(2007).
RN [2] {ECO:0000313|EMBL:ACZ98966.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19751840; DOI=10.1016/j.ympev.2009.09.006;
RA Leache A.D.;
RT "Species trees for spiny lizards (genus Sceloporus): identifying points of
RT concordance and conflict between nuclear and mitochondrial data.";
RL Mol. Phylogenet. Evol. 54:162-171(2010).
RN [3] {ECO:0000313|EMBL:AEI16834.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21787873; DOI=10.1016/j.ympev.2011.07.008;
RA Townsend T.M., Mulcahy D.G., Noonan B.P., Sites J.W.Jr., Kuczynski C.A.,
RA Wiens J.J., Reeder T.W.;
RT "Phylogeny of iguanian lizards inferred from 29 nuclear loci, and a
RT comparison of concatenated and species-tree approaches for an ancient,
RT rapid radiation.";
RL Mol. Phylogenet. Evol. 61:363-380(2011).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; EU085933; ABU45169.1; -; Genomic_DNA.
DR EMBL; GQ464464; ACZ98966.1; -; Genomic_DNA.
DR EMBL; JF806027; AEI16834.1; -; Genomic_DNA.
DR AlphaFoldDB; A9Y4U5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 119..223
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABU45169.1"
FT NON_TER 223
FT /evidence="ECO:0000313|EMBL:ABU45169.1"
SQ SEQUENCE 223 AA; 25087 MW; 9A1EC9D04891C695 CRC64;
SCMKAAPMKE VSLRGQGSLA YPGLRTQGNL ENLGGPNDAT RGLTSLADTF EHVIEELLDE
QQAIQPSKEN KDADLYSSRV MLSSQVPLEP PLLFLLEEYK NYLDAANMSM RVRRHSDPAR
RGELSVCDST SEWVTAAEKK TAVDMSGATV TVLEKVPVPK GQLKQYFYET KCNSKGYTKE
GCRGIDKRYW NSQCRTTQSY VRALTMDNKK RVGWRFIRID TSC
//
