ID A9Y5G7_AMPQE Unreviewed; 1095 AA.
AC A9Y5G7;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Nuclear factor kappa B {ECO:0000313|EMBL:ABW76682.1};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EMBL:ABW76682.1};
RN [1] {ECO:0000313|EMBL:ABW76682.1}
RP NUCLEOTIDE SEQUENCE.
RA Gauthier M.E.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABW76682.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18175145; DOI=10.1007/s00427-007-0197-5;
RA Gauthier M., Degnan B.M.;
RT "The transcription factor NF-kappaB in the demosponge Amphimedon
RT queenslandica: insights on the evolutionary origin of the Rel homology
RT domain.";
RL Dev. Genes Evol. 218:23-32(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; EU090230; ABW76682.1; -; mRNA.
DR RefSeq; NP_001266238.1; NM_001279309.1.
DR AlphaFoldDB; A9Y5G7; -.
DR SMR; A9Y5G7; -.
DR GeneID; 100616089; -.
DR KEGG; aqu:100616089; -.
DR OrthoDB; 1059550at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08310; Death_NFkB-like; 1.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07883; RHD-n_NFkB; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF28; NUCLEAR FACTOR NF-KAPPA-B P110 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 48..248
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 688..710
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 729..761
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 762..794
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 805..837
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 873..905
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 487..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 118617 MW; 09703736A95A975C CRC64;
MAFNGIDPSS LPEALIRDTM NTLPTHIVNS NPDSLNSSPY SSLTQVRLEI VEQPKSRGFR
FRYDCEGQSH GGLPGENSEK NRRQKTYPTV HLKGYRGRAR VMVSLVTDSD PAMPHAHSIV
GKNAIDGRCV VEIGPETDMY AQFTSLGILH VTKKKVPEVL TRRLLQQTTP RGQMVDQMEV
VDVDMTTAQL TSEEQDEIHQ QAQTLAKSMN LSVVRLCFQA FLPDENGRYT IPIDPVFSNK
VYDSKAPSAG TLKICRLDRT SGSVKGGDDV FLLCDKVQKN DIEVVFYEDK QETTGGMQLQ
PWMAKGRFGP NDVHHQYAIV FQTPTFYNQA IEHPVQVWIA LKRPSDHETS EPKPFLYLPQ
EFDEERIGQK RRKKITHFNN FFEGPGGGGG AGGGAGGAGG NFFSRDFNYG SGGGYNSGFN
FFGGSSGGGG GSGGGSANNA GTGGGTTFSG GNTSAANMPV SVDSLYSTLP PSSNQHIFAA
TATNPHYPHM RQQQPHGLSF SNGGGRGMGG TMYSHAMDQQ FMSTASGHLV SRTGAGGVTV
KREPPDYYMD VERDNVQPPL PALSEEGGTG GGNIMRPKDQ LPPSQRGPGD SGKLLDVSSN
IEDVESGYVE AERMDSGLPT SMAAEPSQES TSSETEAQQA LQALKDRQQM AFEVCDRMFN
ALLAWATTKD IRYLLAAQRS LTAVQNQEGD TALHLAIIHN HQDVVLQLLD VLPQLPPTET
PVVDCLNNFK QSPVHLAVIT RQHKVVQYLL KANANPLVSD RNGDTPLHLA CKYGFLQGIV
PLLNRSTRIN TEGCRIPELV MRNNDGLTPL HLAAACGNPD CFKELVKAHA DVNVQDSKSG
KSALHYLIEK GDLPLTGFLI TESETNIECT DFSGNTPLHC AAALGNVAIV SLLIAAGANL
VCQNQEGELP LVLAEYGGHE EVVKVLKDSL VKAGLDKPEE QLSTQMKSVS LTEEDKALAA
LRANSSEGDL SKLDFRPRIS LALILDPINE GCDWKALAKC LSLSHLEAGL EAMTSPTKEL
LTMYEACDGT IAKLRQALLD INRSDAVNII DRYMQEEKGI VTSKQTYDSG ISSNPSSLSN
EQVVGKHSTI PSSQV
//
