ID   A9YLB5_9ACTO            Unreviewed;      1576 AA.
AC   A9YLB5;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   06-MAR-2013, entry version 35.
DE   SubName: Full=AngAIV;
GN   Name=angAIV;
OS   Streptomyces eurythermus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=42237;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 23956;
RA   Kaulmann U., Haydock S.F., Kaja A.L.;
RT   "Engineered biosynthesis of hybrid macrolide polyketides containing D-
RT   angolosamine and D-mycaminose.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; EU220288; ABY21541.1; -; Genomic_DNA.
DR   ProteinModelPortal; A9YLB5; -.
DR   SMR; A9YLB5; 4-904.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   Gene3D; 3.40.366.10; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 3.40.50.720; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR020842; PKS/FAS_KR.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP_like; 1.
DR   SUPFAM; SSF52151; Acyl_Trfase/lysoPlipase; 1.
DR   SUPFAM; SSF55048; Malonyl_transacylase_ACP-bd; 1.
DR   SUPFAM; SSF101173; Polyketide_synth_docking; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine; Transferase.
SQ   SEQUENCE   1576 AA;  163869 MW;  43541FEF05E7552C CRC64;
     MADEQELRAY LKRTTIELHR ATTRLKKTEE QAHEPIAIVG MACRFPGGVG SPEDLWELVA
     TGTDAVSPFP SDRGWDVAGL YDPDPAAVGR TYCREGGFLH GAGEFDAGFF GISPREAVAM
     DPQQRLLLET SWEALERAGI DPRTLRGSRT GVYVGAWDGG YTRDVDASSA ELEGDLLTGG
     VVSFSSGRIS YVLGLEGPAM SVDTACSSSL VALHLAVQAL RRGECDLALA GGVTVMATPT
     VFVQFSRQRG VAPDGRCKAF SDEADGFGPA EGVGVLAVER LSDARRRGHR VLAVVRGSAV
     NQDGASNGLT APSGPSQERV IARALADARL TAGDVDVVEA HGTGTRLGDP IEAQALLATY
     GRGRSADRPL WLGSLKSNIG HAQAAAGVAG VIKMVMAMRH GVLPRSLHVG VPSSHVDWSS
     GGVEVLTRAR AWPVVERVRR AAVSAFGVSG TNAHVVLEQA PEEPGEAEVV PGPVKHPVPV
     VVSGASAKAL DAGLGRLAAW VESDGGLGVG EVGWSAAQRS VFGHRAVVVA SGREELLKGL
     KTPVVSGVAG SVGRSVLVFP GQGTQWAGMG AELLDMSPVF AARMGECAAA LSPFVGWDLL
     EVVRSGEGLE RVDVVQPVTW AVMVSLAEVW AACGVKPDAV VGHSQGEIAA AVVSGALSLQ
     DGARVVALRS QVIGRVLAGA GGMASVALPA SVVEERLSGW SDRLGIAAVN GPAITVVSGD
     ADAVGEFLEA CERDGVRARR IPVDYASHSA QVEAIEAKLA SLLAPVVARD PHIPFYSTVE
     PGRPVRTDAG YWYRNLRRRV QFAETVDLLL ADGFGAFIEA SAHPVLTIGI QELADQASTD
     REVVVTGTLR KGEGGLRRLW TSMAEAFVHG VAVDWKAAYA AHGLTARRVD LPTYPFQRRH
     YWLDTAPHSR DRMRGAETAG IEAWRHKVVW KGLPTEETAR LSGRWLLVLP EGTDPGPADD
     IADVLGRHGA TVRRLVADPV ALGRDGLAAR ISGTWDGILS LLPADERPHP AHPSLDRATV
     GTVLLAQAVS DIGTGARLWT VTRRAVAVAA GEEPSTAGAQ VWGVGRGIAL ELPTVWGGLV
     DLPDAPDARC LRRLAWVLAA AGAEDQVAVR ASGAYGRRLA PAGGAAGEGR AYTPRGTVLV
     TGGTGALGGH VARWLAVNGA EHLVLTSRRG QDAPGAAALT AELEARGVRV TVVACDVSDC
     AALAALLDEH PPTAVFHTAG VPHSGAFLDL RTDGMADVYG GKVTGARHLD ELTRERDLDA
     FVLYTSGAGV WGSGGQTAYG AANAALDALA ERRRAGGLPA TAIAWGLWAG GGMGEGDGEE
     FLSERGLRAM PPESALESLG VALERGDTCV AVAHVDWPRF ARSFTAFRPS PLIGDLAGTG
     GAGERYGDGE ESTGDQGFLA RYTACGPVER REMLLDLVRR QVAAVLGHAG PEEVPADQAF
     RDLGFSSLTA VEAATRLGRA VGAKLPPTLV FDHPTAEAVG DHLAEVLEAR VPAEASPGEE
     QRIRAALATL PVNALREAGL LDGLLALAAA HAPAGQAAAR PSSAPADAAG PADTLDSIDE
     LDDDALIALA LGEAGS
//