ID A9YN29_9TELE Unreviewed; 185 AA.
AC A9YN29;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Preproinsulin-like growth factor-I {ECO:0000313|EMBL:ABY27564.1};
OS Odontesthes bonariensis (pejerrey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Atheriniformes; Atherinopsidae;
OC Atherinopsinae; Odontesthes.
OX NCBI_TaxID=219752 {ECO:0000313|EMBL:ABY27564.1};
RN [1] {ECO:0000313|EMBL:ABY27564.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18521839; DOI=10.1002/jez.466;
RA Sciara A.A., Somoza G.M., Arranz S.E.;
RT "Insulin-like growth factor-I of pejerrey, Odontesthes bonariensis: cDNA
RT characterization, tissue distribution and expression profiles after growth
RT hormone administration.";
RL J. Exp. Zool. Part A Ecol. Genet. Physiol. 309:407-418(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; EU257205; ABY27564.1; -; mRNA.
DR AlphaFoldDB; A9YN29; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845:SF3; INSULIN-LIKE GROWTH FACTOR 1; 1.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..43
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 44..185
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002747329"
FT DOMAIN 47..103
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 113..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 50..90
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 62..103
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 89..94
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 185 AA; 20304 MW; 65FD4909933EF92F CRC64;
MSSAHSSQWH LYDVLKGAMC CISCSHTLSL LLCVLTLTPT ATGAGPETLC GAELVDTLQF
VCGERGFYFS KPTGYGPNAR RSRGIVDECC FQSCELRRLE MYCAPAKSGK AARSVRSQRH
TDMPRAPKVS TPGHKVDKGT ERRTAQQPDK TKKKRPLPGH SHSSFKEVHQ KNSSRGSAGG
KNYRM
//
