ID A9Z0R3_ORFV Unreviewed; 183 AA.
AC A9Z0R3;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=DsRNA-binding interferon resistance protein {ECO:0000313|EMBL:ASL69121.1};
DE SubName: Full=Interferon-resistance protein {ECO:0000313|EMBL:ABY41265.1, ECO:0000313|EMBL:AHL29093.1};
DE SubName: Full=VIR protein {ECO:0000313|EMBL:AHY18980.1};
DE SubName: Full=Virus interferon resistance protein {ECO:0000313|EMBL:AEW70359.1};
GN Name=E3L {ECO:0000313|EMBL:ABY41265.1};
GN Synonyms=IFNR {ECO:0000313|EMBL:AHL29093.1}, ORF020
GN {ECO:0000313|EMBL:ASL69121.1}, VIR {ECO:0000313|EMBL:AEW70359.1};
OS Orf virus (ORFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Parapoxvirus.
OX NCBI_TaxID=10258 {ECO:0000313|EMBL:ABY41265.1};
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1] {ECO:0000313|EMBL:ABY41265.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nantou {ECO:0000313|EMBL:ABY41265.1};
RA Chan K.-W., Lin J.-W., Hsu W.-L., Wong M.-L.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACH69627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hoping {ECO:0000313|EMBL:ACH69627.1};
RA Chan K.-W., Yang C.-H., Lin F.-Y., Hsu W.-L., Wong M.-L.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABY41265.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nantou {ECO:0000313|EMBL:ABY41265.1};
RX PubMed=19061942; DOI=10.1016/j.gene.2008.10.029;
RA Chan K.W., Yang C.H., Lin J.W., Wang H.C., Lin F.Y., Kuo S.T., Wong M.L.,
RA Hsu W.L.;
RT "Phylogenetic analysis of parapoxviruses and the C-terminal heterogeneity
RT of viral ATPase proteins.";
RL Gene 432:44-53(2009).
RN [4] {ECO:0000313|EMBL:ACH69627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hoping {ECO:0000313|EMBL:ACH69627.1};
RX PubMed=19409929; DOI=10.1016/j.jviromet.2009.04.025;
RA Chan K.W., Hsu W.L., Wang C.Y., Yang C.H., Lin F.Y., Chulakasian S.,
RA Wong M.L.;
RT "Differential diagnosis of orf viruses by a single-step PCR.";
RL J. Virol. Methods 160:85-89(2009).
RN [5] {ECO:0000313|EMBL:AEW70359.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ORFV/ShanX/2011/China {ECO:0000313|EMBL:AEW70359.1};
RX PubMed=23443934; DOI=10.1007/s00705-013-1641-7;
RA Li H., Zhu X., Zheng Y., Wang S., Liu Z., Dou Y., Li H., Cai X., Luo X.;
RT "Phylogenetic analysis of two Chinese orf virus isolates based on sequences
RT of B2L and VIR genes.";
RL Arch. Virol. 158:1477-1485(2013).
RN [6] {ECO:0000313|EMBL:AHL29093.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orfv-chGanSu {ECO:0000313|EMBL:AHL29093.1};
RA Cheng W., Zhang K., Liu Y., Kong H., Shang Y., Liu X.;
RT "Phylogenetic analysis of China Orf virus isolate interferon-resistance
RT gene.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AHY18980.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HB {ECO:0000313|EMBL:AHY18980.1};
RA Sheer L.;
RT "Current Status of Contagious Ecthyma in Goat or Sheep.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:ASL69121.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AH1508 {ECO:0000313|EMBL:ASL69121.1}, AH1610
RC {ECO:0000313|EMBL:ASL69123.1}, AH1612 {ECO:0000313|EMBL:ASL69124.1},
RC AH1701 {ECO:0000313|EMBL:ASL69125.1}, and AH1704
RC {ECO:0000313|EMBL:ASL69126.1};
RA Sun Z.S., Albrecht U., Echele G., Lee C.C.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EU327507; ABY41265.1; -; Genomic_DNA.
DR EMBL; EU935104; ACH69627.1; -; Genomic_DNA.
DR EMBL; JN565697; AEW70359.1; -; Genomic_DNA.
DR EMBL; KF916586; AHL29093.1; -; Genomic_DNA.
DR EMBL; KJ637024; AHY18980.1; -; Genomic_DNA.
DR EMBL; MF489118; ASL69121.1; -; Genomic_DNA.
DR EMBL; MF489120; ASL69123.1; -; Genomic_DNA.
DR EMBL; MF489121; ASL69124.1; -; Genomic_DNA.
DR EMBL; MF489122; ASL69125.1; -; Genomic_DNA.
DR EMBL; MF489123; ASL69126.1; -; Genomic_DNA.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0039580; P:suppression by virus of host PKR signaling; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR GO; GO:0039557; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity; IEA:UniProtKB-KW.
DR CDD; cd19875; DSRM_EIF2AK2-like; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR009179; E3L.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF02295; z-alpha; 1.
DR PIRSF; PIRSF004008; VAC_E3L; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00550; Zalpha; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS50139; Z_BINDING; 1.
PE 4: Predicted;
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Inhibition of host IRF3 by virus {ECO:0000256|ARBA:ARBA00022931};
KW Inhibition of host IRF7 by virus {ECO:0000256|ARBA:ARBA00022811};
KW Inhibition of host PKR by virus {ECO:0000256|ARBA:ARBA00023041};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023041};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 1..63
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 109..177
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
SQ SEQUENCE 183 AA; 19883 MW; 357B5B236E5C8BCC CRC64;
MACECASLIL ELLRKSDDKL PAKQIAKELG ISKHEANRQL YRLLDSDDVC CEDGNPPRWF
VECAPSAPTE EDENSDTEPM ETEAGCDTLF GGDIDIMTQS SVMRLKSLNP VSAVNEFCMM
THRSLEFCET RSGGKDHCPL FTCTITISGK VVAAADGASK KLARHTACAS ALTILINNCG
ISF
//
